GGL

GAMMA-L-GLUTAMIC ACID

Find entries where: GGL

is present as a standalone ligand in 15 entries

as a non-polymer is covalently linked to polymer or other heterogen groups 4 entries

is present in a polymer sequence 12 entries

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Chemical Component Summary
Name	GAMMA-L-GLUTAMIC ACID
Synonyms	L-GLUTAMIC ACID
Identifiers	(2S)-2-azanylpentanedioic acid
Formula	C₅ H₉ N O₄
Molecular Weight	147.129
Type	L-GAMMA-PEPTIDE, C-DELTA LINKING
Isomeric SMILES	C(CC(=O)O)[C@@H](C(=O)O)N
InChI	InChI=1S/C5H9NO4/c6-3(5(9)10)1-2-4(7)8/h3H,1-2,6H2,(H,7,8)(H,9,10)/t3-/m0/s1
InChIKey	WHUUTDBJXJRKMK-VKHMYHEASA-N

Chemical Details
Formal Charge	0
Atom Count	19
Chiral Atom Count	1
Bond Count	18
Aromatic Bond Count	0

Drug Info: DrugBank

DrugBank ID	DB00142
Name	Glutamic acid
Groups	approved nutraceutical
Description	A peptide that is a homopolymer of glutamic acid.
Synonyms	Glutamic acid L-Glutaminic acid (2S)-2-Aminopentanedioic acid L-Glutamic acid L-Glutamate Glutamic acid hydrochloride Glu (S)-2-Aminopentanedioic acid ácido glutámico (S)-Glutamic acid
Brand Names	Aminosyn II 8.5% With 50% Dextrose Periolimel 2.5% E Aminosyn II 8.5% M In 20% Dextrose (dual Chamber) Glutamic Acid Pepsin and Betaine Tablets Aminosyn-PF 7% Vamin 18 Electrolyte-free Vamin N Kabiven 20% Prosol Primene 10% Clinisol Olimel 3.3% E Aminosyn II Stomach Aid-digestive Aid Aminosyn II 7% With 10% Dextrose Aminosyn II 7% M In 10% Dextrose(dual Chamber) Women Secret Plenamine Aminosyn II 7% With 50% Dextrose Glutamic Acid HCl Betaine HCl W Pepsin Primene Women Secret Care Aminosyn II 5% Inj Aminosyn-PF 10% Aminosyn II and Dextrose Aminosyn II 10% With Electrolytes Aminosyn II in Dextrose Olimel 7.6% Glutamic Acid Hydrochloride Nu Life Primene 10%-liq IV TrophAmine ProSol Olimel 4.4% Aminosyn II 8.5% Injection Premasol - sulfite-free (Amino Acid) Aminosyn II In Dextrose Injection Olimel 5.7% E Glutamic Acid HCl Cap 325mg Novamine Perikabiven Aminosyn II with Electrolytes Olimel 5.7% Olimel 7.6% E Aminosyn II 7% Injection Aminosyn II with Electrolytes in Dextrose with Calcium Olimel 4.4% E Aminosyn-PF
Indication	Considered to be nature's "Brain food" by improving mental capacities; helps speed the healing of ulcers; gives a "lift" from fatigue; helps control alcoholism, schizophrenia and the craving for sugar.
Categories	Acid Preparations Alimentary Tract and Metabolism Amino Acids Amino Acids, Acidic Amino Acids, Dicarboxylic Amino Acids, Peptides, and Proteins Dietary Supplements Digestives, Incl. Enzymes Excitatory Amino Acids Gastrointestinal Acidifying Agents Gastrointestinal Agents Glutamates Proteinogenic Amino Acids Supplements
ATC-Code	A09AB01
CAS number	56-86-0

Drug Targets

Name	Target Sequence	Pharmacological Action	Actions
Metabotropic glutamate receptor 1	MVGLLLFFFPAIFLEVSLLPRSPGRKVLLAGASSQRSVARMDGDVIIGAL...	unknown
Metabotropic glutamate receptor 4	MPGKRGLGWWWARLPLCLLLSLYGPWMPSSLGKPKGHPHMNSIRIDGDIT...	unknown
Glutamate receptor ionotropic, kainate 4	MPRVSAPLVLLPAWLVMVACSPHSLRIAAILDDPMECSRGERLSITLAKN...	unknown
Glutamate receptor ionotropic, kainate 5	MPAELLLLLIVAFASPSCQVLSSLRMAAILDDQTVCGRGERLALALAREQ...	unknown
Metabotropic glutamate receptor 7	MVQLRKLLRVLTLMKFPCCVLEVLLCALAAAARGQEMYAPHSIRIEGDVT...	unknown
Metabotropic glutamate receptor 8	MVCEGKRSASCPCFFLLTAKFYWILTMMQRTHSQEYAHSIRVDGDIILGG...	unknown
Excitatory amino acid transporter 5	MVPHAILARGRDVCRRNGLLILSVLSVIVGCLLGFFLRTRRLSPQEISYF...	unknown
5-oxoprolinase	MGSPEGRFHFAIDRGGTFTDVFAQCPGGHVRVLKLLSEDPANYADAPTEG...	unknown
Phosphoribosylformylglycinamidine synthase	MSPVLHFYVRPSGHEGAAPGHTRRKLQGKLPELQGVETELCYNVNWTAEA...	unknown
Branched-chain-amino-acid aminotransferase, mitochondrial	MAAAALGQIWARKLLSVPWLLCGPRRYASSSFKAADLQLEMTQKPHKKPG...	unknown
Glutamate receptor ionotropic, NMDA 2D	MRGAGGPRGPRGPAKMLLLLALACASPFPEEAPGPGGAGGPGGGLGGARP...	unknown
Glutaminase kidney isoform, mitochondrial	MMRLRGSGMLRDLLLRSPAGVSATLRRAQPLVTLCRRPRGGGRPAAGPAA...	unknown
Aspartate aminotransferase, mitochondrial	MALLHSGRVLPGIAAAFHPGLAAAASARASSWWTHVEMGPPDPILGVTEA...	unknown
Bifunctional glutamate/proline--tRNA ligase	MATLSLTVNSGDPPLGALLAVEHVKDDVSISVEEGKENILHVSENVIFTD...	unknown
Asparagine synthetase [glutamine-hydrolyzing]	MCGIWALFGSDDCLSVQCLSAMKIAHRGPDAFRFENVNGYTNCCFGFHRL...	unknown
Glutamine synthetase	MTTSASSHLNKGIKQVYMSLPQGEKVQAMYIWIDGTGEGLRCKTRTLDSE...	unknown
Aspartate aminotransferase, cytoplasmic	MAPPSVFAEVPQAQPVLVFKLTADFREDPDPRKVNLGVGAYRTDDCHPWV...	unknown
Tyrosine aminotransferase	MDPYMIQMSSKGNLPSILDVHVNVGGRSSVPGKMKGRKARWSVRPSDMAK...	unknown
Alanine aminotransferase 1	MASSTGDRSQAVRHGLRAKVLTLDGMNPRVRRVEYAVRGPIVQRALELEQ...	unknown
Vitamin K-dependent gamma-carboxylase	MAVSAGSARTSPSSDKVQKDKAELISGPRQDSRIGKLLGFEWTDLSSWRR...	unknown
Excitatory amino acid transporter 1	MTKSNGEEPKMGGRMERFQQGVRKRTLLAKKKVQNITKEDVKSYLFRNAF...	unknown
Excitatory amino acid transporter 2	MASTEGANNMPKQVEVRMHDSHLGSEEPKHRHLGLRLCDKLGKNLLLTLT...	unknown
Excitatory amino acid transporter 3	MGKPARKGCEWKRFLKNNWVLLSTVAAVVLGITTGVLVREHSNLSTLEKF...	unknown
Glutamate--cysteine ligase catalytic subunit	MGLLSQGSPLSWEETKRHADHVRRHGILQFLHIYHAVKDRHKDVLKWGDE...	unknown	substrate
Excitatory amino acid transporter 4	MSSHGNSLFLRESGQRLGRVGWLQRLQESLQQRALRTRLRLQTMTLEHVL...	unknown
Glutamate dehydrogenase 2, mitochondrial	MYRYLAKALLPSRAGPAALGSAANHSAALLGRGRGQPAAASQPGLALAAR...	unknown	substrate
GMP synthase [glutamine-hydrolyzing]	MALCNGDSKLENAGGDLKDGHHHYEGAVVILDAGAQYGKVIDRRVRELFV...	unknown
Branched-chain-amino-acid aminotransferase, cytosolic	MKDCSNGCSAECTGEGGSKEVVGTFKAKDLIVTPATILKEKPDPNNLVFG...	unknown
4-aminobutyrate aminotransferase, mitochondrial	MASMLLAQRLACSFQHSYRLLVPGSRHISQAAAKVDVEFDYDGPLMKTEV...	unknown
Glutamate receptor ionotropic, NMDA 1	MSTMRLLTLALLFSCSVARAACDPKIVNIGAVLSTRKHEQMFREAVNQAN...	unknown
Folylpolyglutamate synthase, mitochondrial	MSRARSHLRAALFLAAASARGITTQVAARRGLSAWPVPQEPSMEYQDAVR...	unknown
Glutamyl aminopeptidase	MNFAEREGSKRYCIQTKHVAILCAVVVGVGLIVGLAVGLTRSCDSSGDGG...	unknown
Glutamate receptor ionotropic, NMDA 2A	MGRVGYWTLLVLPALLVWRGPAPSAAAEKGPPALNIAVMLGHSHDVTERE...	unknown
Glutamate receptor ionotropic, NMDA 2B	MKPRAECCSPKFWLVLAVLAVSGSRARSQKSPPSIGIAVILVGTSDEVAI...	unknown
Glutamate receptor ionotropic, NMDA 2C	MGGALGPALLLTSLFGAWAGLGPGQGEQGMTVAVVFSSSGPPQAQFRARL...	unknown
Probable glutamate--tRNA ligase, mitochondrial	MAALLRRLLQRERPSAASGRPVGRREANLGTDAGVAVRVRFAPSPTGFLH...	unknown
Glutamine-dependent NAD(+) synthetase	MGRKVTVATCALNQWALDFEGNLQRILKSIEIAKNRGARYRLGPELEICG...	unknown	product of
N-acetylglutamate synthase, mitochondrial	MATALMAVVLRAAAVAPRLRGRGGTGGARRLSCGARRRAARGTSPGRRLS...	unknown
Kynurenine/alpha-aminoadipate aminotransferase, mitochondrial	MNYARFITAASAARNPSPIRTMTDILSRGPKSMISLAGGLPNPNMFPFKT...	unknown
Glutamate receptor ionotropic, NMDA 3A	MRRLSLWWLLSRVCLLLPPPCALVLAGVPSSSSHPQPCQILKRIGHAVRV...	unknown
Alanine aminotransferase 2	MQRAAALVRRGCGPRTPSSWGRSQSSAAAEASAVLKVRPERSRRERILTL...	unknown	substrate,product of
Alpha-aminoadipic semialdehyde synthase, mitochondrial	MLQVHRTGLGRLGVSLSKGLHHKAVLAVRREDVNAWERRAPLAPKHIKGI...	unknown
Glutaminase liver isoform, mitochondrial	MRSMKALQKALSRAGSHCGRGGWGHPSRSPLLGGGVRHHLSEAAAQGRET...	unknown
Aspartyl aminopeptidase	MQVAMNGKARKEAVQTAAKELLKFVNRSPSPFHAVAECRNRLLQAGFSEL...	unknown
Cystine/glutamate transporter	MVRKPVVSTISKGGYLQGNVNGRLPSLGNKEPPGQEKVQLKRKVTLLRGV...	unknown
Carboxypeptidase Q	MKFLIFAFFGGVHLLSLCSGKAICKNGISKRTFEEIKEEIASCGDVAKAI...	unknown
Phosphoserine aminotransferase	MDAPRQVVNFGPGPAKLPHSVLLEIQKELLDYKGVGISVLEMSHRSSDFA...	unknown
Glutamate dehydrogenase 1, mitochondrial	MYRYLGEALLLSRAGPAALGSASADSAALLGWARGQPAAAPQPGLALAAR...	unknown
Glutamate receptor ionotropic, kainate 1	MEHGTLLAQPGLWTRDTSWALLYFLCYILPQTAPQVLRIGGIFETVENEP...	unknown
Glutamate receptor 1	MQHIFAFFCTGFLGAVVGANFPNNIQIGGLFPNQQSQEHAAFRFALSQLT...	unknown
Glutamate--cysteine ligase regulatory subunit	MGTDSRAAKALLARARTLHLQTGNLLNWGRLRKKCPSTHSEELHDCIQKT...	unknown
Glutamate carboxypeptidase 2	MWNLLHETDSAVATARRPRWLCAGALVLAGGFFLLGFLFGWFIKSSNEAT...	unknown
Glutamate decarboxylase 2	MASPGSGFWSFGSEDGSGDSENPGTARAWCQVAQKFTGGIGNKLCALLYG...	unknown
Glutamate decarboxylase 1	MASSTPSSSATSSNAGADPNTTNLRPTTYDTWCGVAHGCTRKLGLKICGF...	unknown
Formimidoyltransferase-cyclodeaminase	MSQLVECVPNFSEGKNQEVIDAISGAITQTPGCVLLDVDAGPSTNRTVYT...	unknown
Glutamate receptor 2	MQKIMHISVLLSPVLWGLIFGVSSNSIQIGGLFPRGADQEYSAFRVGMVQ...	unknown
Glutamate receptor 3	MARQKKMGQSVLRAVFFLVLGLLGHSHGGFPNTISIGGLFMRNTVQEHSA...	unknown
Glutamate receptor 4	MRIISRQIVLLFSGFWGLAMGAFPSSVQIGGLFIRNTDQEYTAFRLAIFL...	unknown
Delta-1-pyrroline-5-carboxylate synthase	MLSQVYRCGFQPFNQHLLPWVKCTTVFRSHCIQPSVIRHVRSWSNIPFIT...	unknown
Glutamate receptor ionotropic, kainate 2	MKIIFPILSNPVFRRTVKLLLCLLWIGYSQGTTHVLRFGGIFEYVESGPM...	unknown
Glutamate receptor ionotropic, kainate 3	MTAPWRRLRSLVWEYWAGLLVCAFWIPDSRGMPHVIRIGGIFEYADGPNA...	unknown
Aspartate aminotransferase	MAPPSVFAEVPQAQPVLVFKLTADFREDPDPRKVNLGVGAYRTDDCHPWV...	unknown	substrate
Monocarboxylate transporter 10	MVLSQEEPDSARGTSEAQPLGPAPTGAAPPPGPGPSDSPEAAVEKVEVEL...	unknown	substrate,inhibitor
Monocarboxylate transporter 1	MPPAVGGPVGYTPPDGGWGWAVVIGAFISIGFSYAFPKSITVFFKEIEGI...	unknown	substrate
Mitochondrial glutamate carrier 2	MTHQDLSITAKLINGGVAGLVGVTCVFPIDLAKTRLQNQHGKAMYKGMID...	unknown
Mitochondrial glutamate carrier 1	MADKQISLPAKLINGGIAGLIGVTCVFPIDLAKTRLQNQQNGQRVYTSMS...	unknown
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Drug Info/Drug Targets: DrugBank 3.0: a comprehensive resource for 'omics' research on drugs. Knox C, Law V, Jewison T, Liu P, Ly S, Frolkis A, Pon A, Banco K, Mak C, Neveu V, Djoumbou Y, Eisner R, Guo AC, Wishart DS. Nucleic Acids Res. 2011 Jan; 39 (Database issue):D1035-41. | PMID:21059682

Related Resource References

Resource Name	Reference
Pharos	CHEMBL575060
PubChem	44272391, 33032, 88747398
ChEMBL	CHEMBL575060
ChEBI	CHEBI:16015, CHEBI:53374
CCDC/CSD	LGLUTA02, LGLUTA03, ZZZBUS01, JOGLOJ, FACXIR, ZARBOM, JEJVIE, BEZQEE, LGLUTA, UCAJEN, DUSMAF, GUHLUR, JEMNOF

RCSB PDB Core Operations are funded by the U.S. National Science Foundation (DBI-2321666), the US Department of Energy (DE-SC0019749), and the National Cancer Institute, National Institute of Allergy and Infectious Diseases, and National Institute of General Medical Sciences of the National Institutes of Health under grant R01GM157729.

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GGL

GAMMA-L-GLUTAMIC ACID

Chemical Component Summary

Chemical Details

Drug Info: DrugBank

Drug Targets

Related Resource References