HCY

(11alpha,14beta)-11,17,21-trihydroxypregn-4-ene-3,20-dione

Created:	2007-10-13
Last modified:	2021-03-01

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13 entries where HCY is found as a standalone ligand

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Chemical Details
Formal Charge	0
Atom Count	56
Chiral Atom Count	7
Bond Count	59
Aromatic Bond Count	0

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Chemical Component Summary
Name	(11alpha,14beta)-11,17,21-trihydroxypregn-4-ene-3,20-dione
Synonyms	CORTISOL
Systematic Name (OpenEye OEToolkits)	(8S,9S,10R,11S,13S,14S,17R)-11,17-dihydroxy-17-(2-hydroxyethanoyl)-10,13-dimethyl-2,6,7,8,9,11,12,14,15,16-decahydro-1H-cyclopenta[a]phenanthren-3-one
Formula	C₂₁ H₃₀ O₅
Molecular Weight	362.46
Type	NON-POLYMER

Chemical Descriptors
Type	Program	Version	Descriptor
SMILES	ACDLabs	10.04	O=C(CO)C3(O)C2(CC(O)C4C1(C(=CC(=O)CC1)CCC4C2CC3)C)C
SMILES	CACTVS	3.341	C[C]12CCC(=O)C=C1CC[CH]3[CH]4CC[C](O)(C(=O)CO)[C]4(C)C[CH](O)[CH]23
SMILES	OpenEye OEToolkits	1.5.0	CC12CCC(=O)C=C1CCC3C2C(CC4(C3CCC4(C(=O)CO)O)C)O
Canonical SMILES	CACTVS	3.341	C[C@]12CCC(=O)C=C1CC[C@H]3[C@@H]4CC[C@](O)(C(=O)CO)[C@@]4(C)C[C@H](O)[C@H]23
Canonical SMILES	OpenEye OEToolkits	1.5.0	C[C@]12CCC(=O)C=C1CC[C@@H]3[C@@H]2[C@H](C[C@]4([C@H]3CC[C@@]4(C(=O)CO)O)C)O
InChI	InChI	1.03	InChI=1S/C21H30O5/c1-19-7-5-13(23)9-12(19)3-4-14-15-6-8-21(26,17(25)11-22)20(15,2)10-16(24)18(14)19/h9,14-16,18,22,24,26H,3-8,10-11H2,1-2H3/t14-,15-,16-,18+,19-,20-,21-/m0/s1
InChIKey	InChI	1.03	JYGXADMDTFJGBT-VWUMJDOOSA-N

Drug Info: DrugBank

DrugBank ID	DB00741
Name	Hydrocortisone
Groups	approved vet_approved
Description	Hydrocortisone, or cortisol, is a glucocorticoid secreted by the adrenal cortex.[A188387] Hydrocortisone is used to treat immune, inflammatory, and neoplastic conditions.[L10529,L10532,L10535,L10538,L7772,L7321] It was discovered in the 1930s by Edward Kendall and named Compound F, or 17-hydroxycorticosterone.[A188420] Hydrocortisone was granted FDA approval on 5 August 1952.[L10574]
Synonyms	Kendall's compound F 4-pregnen-11β,17α,21-triol-3,20-dione 11beta-hydrocortisone (11β)-11,17,21-trihydroxypregn-4-ene-3,20-dione 11beta,17alpha,21-Trihydroxy-4-pregnene-3,20-dione Hidrocortisona Hydrocortisone 17-Hydroxycorticosterone Hydrocortisonum Cortisol 11β-hydrocortisone Reichstein's substance M
Brand Names	meijer Hydrocortisone Family Wellness Max Strength 1 Hydrocortisone Cream DG Health Hydrocortisone Soothe Rodan Fields Careone Anti Itch Health Mart Pharmacy Hydrocortisone Maximum Strength Plus 12 Moisturizers Quality Choice Anti Itch with Aloe Hydrocortisone Maximum Strength with aloe Cortizone 10 Easy Relief Texacort Careone Hydrocortisone 1 Maximum Strength Hydrocortisone 1 Plus 10 Hydrocortisone 0.5% / Hydroquinone 6% / Tretinoin 0.05% Hydrocortisone Rectal Suspension (Retention) Equaline Anti Itch Hydrocortisone Iodoquinol BudPak Anti-Itch Duane Reade Maximum Strength Hydrocortisone Family Wellness Maximum Strength Hydrocortisone Natureplex Hydrocortisone Hydro Smart Sense Anti Itch Maximum Strength Topcare Hydrocortisone Basic Case Hydrocortisone Anti-Itch CVS Anti-Itch Hydrocortisone Texacort Solution 1% Quatriderm Creme Nf FixMySkin Healing Balm Fragrance-Free Alkindi Sprinkle CVS Maximum Strength Feminine Anti-Itch Cream Ketocon Aquacort Lotion 2.5% Publix hydro plus Publix Hydro Cortisone Cream Intensive Healing Aloe Cort Market Basket Anti-Itch Cream Plus Cortisone Maximum Strength Quality Choice Anti-Itch DG Health Hydrocortisone Maximum Strength TopCare Hydrocortisone Loesch HC-10 ANTI-ITCH THERAPY Anti-Itch with Aloe Neomycin, Polymyxin B Sulfates and Hydrocortisone Itch Stuff Welly Human Repair Kit Vioform + Hydrocortisone Up and Up Hydrocortisone One Per Cent Hydrocortisone Cream Intensive Healing 141016 Hydrocortisone 0.5% / Hydroquinone 4% / Tretinoin 0.025% Harris Teeter Anti-Itch HydroSkin Cortisone Up and Up Hydrocortisone Hydrocortisone, Iodoquinol Emo Cort Lotion 2.5% NU-DERM Tolereen Anti-pruritic Walgreens Hydrocortisone Plus 12 Moisturizers FixMySkin Healing Balm Unflavored Itch relief Cream Cortizone 10 Hydratensive Soothing Anti Itch Healing Tree Calming Anti-itch Health Mart Pharmacy Hydrocortisone Maximum Strength with Aloe Hydrocortisone 2.5% / Hydroquinone 4% / Tretinoin 0.025%, Pharmaskincare Multi-Gly Skin Relief Cream ProCure Hydrocortisone Plus Calendula Hydro Skin Home PapKit Family Care Anti-Itch Instant Cooling Itch Relief KAISER PERMANENTE Hydrocortisone Sunmark Hydrocortisone Plus Freds Hydrocortisone Plus 12 Moisturizers Procto-Med HC Alumier MD Post Procedure Kit with Hydrocortisone Nizoral Scalp Itch Relief Clindamycin 1% / Hydrocortisone 2.5% / Niacinamide 4% Proctosedyl Hydrocortisone Plus CVS Cools Itch Fast TrueLipids 1% Hydrocortisone Barrier Cream Vioform Hydrocortisone Mild TopCare Hydrocortisone 1% with Aloe Mycozyl HC Cream Gel Anti Itch Maximum Strength Hydroxate Gel Meijer Intense Healing Basic Care Hydrocortisone Anti-Itch Scalp Relief Maximum Strength Face Values Hydrocortisone With Aloe Family Care Hydrocortisone Preparation H Soothing Relief Anti-itch Hydrocortisone 1% / Hydroquinone 8% / Tretinoin 0.05% Shopko Maximum Strength Regular Strength Hydrocortisone Cream Assured HydroCortisone Intensive Healing Formula Hydrocortisone 0.5% / Hydroquinone 8% / Tretinoin 0.025% Quality Choice Anti Itch ATOPALM Moisturizing Hydrocortisone NeilMed Anti-Itch Rite Aid anti-itch Dermasorb AF Complete Kit FixMySkin Healing Balm Vanilla Flavor Neomycin and Polymyxin B Sulfates and Hydrocortisone Otic Suspension Cortisone 10 Intensive Moisture Creme Hydrocortisone with Aloe Blue-Emu Anti-Itch Cream Cortizone 10 Anti-itch for Diabetics Skin Hydrocortisone Cream Welly Excursion First Aid Kit Insect Bite Relief OLIVIA QUIDO FIRM and FADE I Sterex Crm Plus Cortane-B Cooling Itch Relief Aquanil HC H Plus Holdings Nourishing Rodan and Fields Soothe Hemorrodil Unguento Plus Lucky SuperSoft MAXIMUM STRENGTH ProCure Hydrocortisone Cream Plus Cortisone Plus Aloe Maximum Strength Hydrocortisone Crm 0.5% Hytone Proctozone HC Hydrocortisone 2.5% / Iodoquinol 1% / Ketoconazole 2% Meijer Anti Itch Cream Plus Cortizone 10 Water Resistant Alumier MD Intensive Recovery Sunmark Hydrocortisone with Aloe Maximum Strength Cooling Itch Relief Rite Aid FixMySkin HEALING LIP BALM unflavoured NEOMYCIN and POLYMYXIN B SULFATES and HYDROCORTISONE Emo Cort Sol 2.5% USP 1% Hydrocortisone Equate Hydrocortisone Topical Cortizone 10 Overnight Itch Relief Triple Antibiotic HC Hydrocortisone with Aloe Maximum Strength Cortizone 10 Intensive Healing for Eczema Aquaphor Itch Relief Rite Aid Cortisone SKIN A COOL Hydrocortisone Anti-Itch Total Relief Cortizone 10 Sensitive Skin Anti-itch Creme Oto End 10 Hydrocortisone Anti Itch Cortizone 10 Itch Relief Massaging Rollerball Rexall Hydrocortisone 1 Green Guard Maximum Strength Hydrocortisone Proctocort CeraVe Anti-Itch CareOne Anti Itch Cipro HC Otic Suspension Cortisone 10 Overnight Creme Intensive Healing Anti Itch Viniferamine Hydrocortisone Cream Vanoxide HC Hydro Ear Hydrocortisone Ultra Strength Hydrocortisone With Aloe Hydrocortisone Regular Strength Up and Up anti itch maximum strength Hydrocortisone Crm 1% FixMySkin Healing Balm Vanilla Fragrance Piyanping antiitch Cooling Itch Relief Well at Walgreens Cortizone 10 Intensive Healing Cortizone 10 Poison Ivy Relief Pads Hydrocortisone Plus 12 Moisturizers Maximum Strength S-Cream HYDROCORTISONE 1% Cortizone 10 Hydratensive Healing Anti Itch Cortisporin Ophthalmic WINCO Hydrocortisone Hydroxym Proctosedyl Suppositories Post-Treatment Repair Cream HEM-EASY RELIEF Herbal Anti-Itch MAXIMUM ITCH RELIEF Pediaderm HC Shopko Hydrocortisone Plus 12 Moisturizers Maximum Strength Instant Cooling Itch Relief CVS Sarna Whipped Foam Cortibalm Theraplex AIM Anti-Itch Moisturizing Cream Maximum Strength Gold Bond Medicated Anti-itch Cream Intensive Formula Signature Care Hydrocortisone Equate Hydrocortisone Anti-Itch Scherer Labs Good Neighbor Pharmacy Hydrocortisone With Aloe for Sensitive Skin Casporyn HC Neosporin Essentials Trial Pack Efmody Kera HC Proctosedyl Sup Rugby Hydroskin FixMySkin HEALING BODY BALM Fragrance-Free Leader Hydrocortisone With Aloe Shopko Hydrocortisone ShopRite Hydrocortisone Hydrocortisone 0.5% / Hydroquinone 4% / Tretinoin 0.025% Neomycin and Polymyxin B Sulfates and Hydrocortisone Zims Advanced Hydrocortisone Continuous With Organic Arnica and Aloe Hydrocortisone Micro Cortizone 10 Cooling Intensive Healing Eczema Medi-First Hydrocortisone PS-2896 Hydrocortisone Cream 1%, 0.9g Dermarest Eczema Medicated Care One Hydrocortisone Maximum Strength Hydrocortisone 1% in Absorbase Scalpicin Anti-Itch Maximum Strength AFASSCO 1% Hydrocortisone Cvs Hydrocortisone With Aloe Anti-itch Feminine Care glo SKIN BEAUTY Remedy Gel Shopko Hydrocortisone Maximum Strength Cortizone 10 Ultra Soothing Creme Advanced Hydrocortisone Hydrocortisone Cream 0.5% USP Sterex Lot Plus Our Family Hydrocortisone with Aloe Glytone soothe calming Apres Peel Soothing Balm Dr. Throwers Hydrotet Healerz for Itches Smart Sense Anti Itch TopCare Hydrocortisone Intensive Healing Formula 999 Itch Relieving Cipro Preparation H Hydrocortisone Members Mark Hydrocortisone Cortaine -B Aqueous Cortisporin Corticol-Aloe OLP Hydrocortisone 1% TrueLipids Anti-Itch Barrier Welly First Aid Kit 141061 Hydrocortisone 0.5% / Hydroquinone 8% / Tretinoin 0.025% WinCo Maximum Strength Hydrocortisone Hydrocortisone 2.5% / Levocetirizine Dihydrochloride 2% Welly Itch Fix Medi-First Plus Hydrocortisone Crane Safety Hydrocortisone Xerese Hydrocortisone with aloe Quality Choice Maximum Strength Anti Itch Up and Up Anti Itch Winco Maximum Strength Hydrocortisone Harris Teeter Anti-Itch Intensive Healing Good Neighbor Pharmacy Hydrocortisone Good Neighbor Pharmacy Hydrocortisone with Aloe Procto-Pak Shoprite Hydrocortisone Meijer Anti Itch Harris Teeter Anti-Itch with Aloe Alcortin Dg Health Hydrocortisone Quatriderm Anti-itch Colocort Welly Superhero Supplies Kit Meijer Maximum Strength Anti-itch Cream wiith Aloe Psoriasin Itch Control Monistat Complete Care Instant Itch Relief Shopko Hydrocortisone With Aloe Dermarest Dricort 0.5% Hydrocortisone Anti-itch Medi-Cortisone with Aloe Neomycin and Polymyxin B Sulfates, Bacitracin Zinc, and Hydrocortisone Good Sense Anti Itch hydrocortisone Iodoquinol Cortisone 10 Sensitive Skin Creme Proctosedyl Ointment meijer Itch and Rash Relief Hydrocortisone Cream 0.5% DG health hydrocortisone Cortaid Maximum Strength Up and Up Hydrocortisone Anti Itch H-Releve Anti-Itch Proctosol-HC CVS Health Hydrocortisone Anti Itch Alkindi Odan Proctomyxin HC Auro-hydrocortisone TheraCare Hydrocortisone Cream Anti-Itch Regular Strength Hydrocortisone and Acetic Acid HeXashield Anti Itch Cream with Healing Aloe Eczema Skin Mushatts N9 Berkley and Jensen Hydrocortisone Hydrocortisone 1% with healing aloe Proctol Suppositories CVS Pharmacy Anti-itch Aveeno Hydrocortisone Anti-itch Cream Herb Street Anti-Itch Stick Monistat Soothing Care Itch Relief HydrocortisoneLotion Itch and Bite Relief First Aid Kit UEC Medical Anti-Itch SAFEWAY Hydrocortisone Plus 12 Moisturizers Discount Drug Mart Anti-itch Signature Care Anti Itch Good Neighbor Pharmacy Hydrocortisone Plus 12 Moisturizers Proctozone-HC Cortizone 10 Feminine Itch Relief Rexall Anti Itch Maximum Strength Relief CeraVe Developed with Dermatologists Anti Itch Hydrocortisone Cream 1% Cortate Crm 1% Hydrocortisone Maximum Strength Hydrocortisone 2.5% / Ketoconazole 2% Anti Itch Maximum Strength Plus Odan Proctomyxin HC Suppositories Meijer Maximum Strength Anti-itch Cream with Aloe Gelmicin Hydrocortisone with Aloe Itch and Rash Cream Audiologist Anti-itch Bioelements Immediate Comfort Hydrocortisone Cortizone-10 Soothing Aloe Creme TheraCare Maximum Strength 1% Hydrocortisone Pharmaskincare Acnecare Cream Yes To Coconut Eczema Relief Maximum Strength Hydrocortisone Plus Moisturizing Aloe Neo-poly-bac Hydro Cortizone 10 Cooling Relief Live Better Hydrocortisone with Aloe Mycozyl HC Neomycin and Polymyxin B Sulfates, Bacitracin Zinc and Hydrocortisone OREAD GOLD Anti-Itch Foam Zims Advanced Crack Creme With Hydrocortisone Good Neighbor Pharmacy Anti Itch Duane Reade hydrocortisone Western Family HydroCortisone CliniCalm OLIVIA QUIDO FIRM and FADE II Ala Quin Cortenema CVS Anti itch Hydrocortisone maximum strength Aveeno Hydrocortisone ANTI-ITCH Scalpicin Maximum Strength Formu Care Anti Itch maximum strength Cortaid 12-Hour Advanced Anti-Itch CVS Health Maxium Strentgh Cortisone sunmark Hydrocortisone Thera plus Anti-itch with aloe Hydrocortisone Dermoscribe Ichybum Oticin HC Ear Drops Up and Up Intensive Healing Hydrocortisone Intensive Healing Formula Post Treatment Balm Cortizone 10 for Psoriasis Anti Itch Scarguard MD Schein Hydrocortisone Hydrocortisone 1% Pharmaskincare Brightening Dermarelief Cream Proctol Ointment Calmurid HC Crm Hydrocortisone Continuous Cho-A Care Lot 1% Cortisone maximum strength Premier Value Hydrocortisone Plus 12 Moisturizers HydroSKIN Hydrocortisone HC Dr H Stabilizer Hydrocort FIRST Dukes Mouthwash Compounding Maximum Strength Cortizone 10 Quick Shot 360 Continuous 141017 Hydrocortisone 0.5% / Hydroquinone 6% / Tretinoin 0.025% Rugby Hydrocortisone With Aloe CVS Cortisone Medi-First Duane Reade hydrocortisone plus 12 moisturizers Welly Adventure First Aid Kit Poison Oak and Ivy Dr Lift Soothing Cream Western Family HydroCortisone Plus 12 Moisturizers Pramoxine-HC Proactiv Solution Anti-Itch Scalp Petrocort Antipruritic Lip 21 Oti Rx Scarguard MD Physicians Formula Emo Cort Cream 2.5% Anti itch Dermazene Alacort Ana Cool Rapid Soothing Cooling Formula Aloe Cort Calming Cream Up and Up anti itch Care One hydrocortisone maximum strength meijer Hydrocortisone Plus 12 Moisturizers Anti-itch CVS Maximum Strength Anti-Itch Cream Berkley and Jensen Anti Itch Meijer Max. Strength Anti-Itch Cream Intensive Healing Formula Cortenema Sus 100mg/60ml Hydrocortisone Ointment 0.5% Poison Oak Hydrocortisone Cream 1% with Aloe Vera Beard Medicated Cremo 141060 Hydrocortisone 0.5% / Hydroquinone 4% / Tretinoin 0.025% Refuge HC Cicatricure Ultra Moisturizing Theracort Kirkland Signature Hydrocortisone Plus Maximum Strength Rexall Hydrocortisone Plus Moisturizers Anti-Itch Hydrocortisone Plus 12 Moisturizers Hydroxym Cream Equaline Anti Itch Maximum Strength Hydrocortisone 1 Cortate Ont 1% Ala-Scalp Barriere HC 1% Freds Hydrocortisone with Aloe TopCare Hydrocortisone Plus 12 Moisturizers Maximum-H Hydrocortisone 0.5% / Hydroquinone 6% / Tretinoin 0.025% Barmicil Plus Maximum Strength Cortisone Avedana Hydrocortisone Maximum Strength Maximum Strength Hydrocortisone Cream with Aloe Caldecort DermaCort Anti-itch Cortef Cortomycin Cortizone 10 Cooling Cream Anti-Itch Hydrocortisone 0.5% / Hydroquinone 6% Selsun Blue Scalp Itch Treatment Loesch Anti-Itch Therapy Hydrocaine Post peel Protectant Vitality Institute WinCo Foods Hydrocortisone Cream Intensive Healing Dermoscribe Seborrheic Dermatitis Dr. Sheffield Hydrocortisone Anti itch Fulton Street Market Anti itch Meijer Anti-itch with Aloe First Aid Only Hydrocortisone 1% Anti-Itch Cortizone 10 Intensive Healing Feminine Itch Relief Pediotic Hydrocortisone Cream USP 0.5% ECOLAB Hydrocortisone Cream Maximum Strength Hydrocortisone Cream Rephresh Cooling Family Wellness Hydrocortisone Hydrocortisone D Hydrocortisone Itch Fixer Maximum Strength Anti-Itch Caring Mills Hydrocortisone Thera Plus Shopko Hydrocortisone Intensive Healing Formula Atopalm Maximum Strength Anti-Itch Harris Teeter Anti-Itch Cooling Relief Vosol HC Smart sense Hydrocortisone Maximum Strength Cortisone Cream with Aloe Quadrydern Acetasol HC Cortizone 10 Neosporin Eczema Essentials Anti Itch Meijer Maximum Strength Anti-itch Odan-spor-HC Pediadermics Eczema 2 Hydrocortisone With Aloe Maximum Strength Hydrocortisone 0.5% / Hydroquinone 8% / Tretinoin 0.05% Equate Hydrocortisone Intensive Healing Formula Hydrocortisone Maximum Strength with Aloe Quality Choice Hydrocortisone Maximum Strength Scalpicin Scalp Itch Medication Maximum Strength Hydrocortisone Anti-Itch Cortizone 10 Plus Quality Choice Hydrocortisone Sarna HC Hydrocortisone Plus 10 Moisturizers Makesense Maximum Strength S-Oint HYDROCORTISONE 1% Anusol HC Harris Teeter Maximum Strength Anti-Itch SeaCalm Skin Itch Relief Instant Cooling Plenadren Tecnu Corticool Hydrocortisone Ointment 1% Healthy Accents Cortisone Maximum Strength Exchange Select Hydrocortisone Proctocream HC Cortaid Intensive Therapy Cooling Itch Relief Dermaquest Skin Therapy Post-Skin Resurfacing Balm Smart Sense Hydrocortisone Avedana Hydrocortisone Cream with Aloe Meijer Maximum Strength Anti-itch Cream Ultra Moisturizing Formula 1oz Ti-U-lac HC Lotion Hydrocortisone Butyrate Leader Hydrocortisone Aveeno Hydrocortisone Anti Itch Premier Value Hydrocortisone AVON HeXashield Anti Itch Cream with Healing Aloe Hydrocortisone anti-itch plus Xpect Hydrocortisone Hycort Retention Enema 100mg/60ml Antibiotic Ear (Neo/Polym/HC) Bencort Sandoz Hydrocortisone Family Wellness Barmicil Anti-itch Corti-Sav Weeks and Leo Anti-itch Sandoz Cortimyxin signature care Hydrocortisone Cipro HC Vioform Hydrocortisone FIRST Marys Mouthwash Compounding Quality Choice Itch Relief
Indication	Otic solutions are indicated for infections of the external auditory canal caused by susceptible organisms and with inflammation.[L10529,L10532] Hydrocortisone tablets are indicated for certain endocrine, rheumatic, collagen, allergic, ophthalmic, respiratory, hematologic, neoplastic, edematous, gastrointestinal, and other conditions.[L10535] A hydrocortisone enema is indicated for ulcerative colitis,[L10538] a topical ointment with antibiotics is indicated for corticosteroid responsive dermatoses with infections,[L7772] and a topical cream with [acyclovir] is indicated to treat cold sores.[L7321] Oral granules of hydrocortisone are used as a replacement therapy for Adrenocortical Insufficiency (AI) in children under 17 years of age.[L16533]
Categories	11-Hydroxycorticosteroids 17-Hydroxycorticosteroids Adrenal Cortex Hormones Adrenals Agents for Treatment of Hemorrhoids and Anal Fissures for Topical Use Alimentary Tract and Metabolism Anti-Inflammatory Agents Antidiarrheals, Intestinal Antiinflammatory/antiinfective Agents Corticosteroid Hormone Receptor Agonists Corticosteroids Corticosteroids Acting Locally Corticosteroids for Local Oral Treatment Corticosteroids for Systemic Use Corticosteroids for Systemic Use, Plain Corticosteroids, Dermatological Preparations Corticosteroids, Weak (Group I) Cytochrome P-450 CYP2A6 Inducers Cytochrome P-450 CYP2B6 Inducers Cytochrome P-450 CYP2B6 Inducers (strength unknown) Cytochrome P-450 CYP2C19 Inducers Cytochrome P-450 CYP2C19 Inducers (strength unknown) Cytochrome P-450 CYP2C8 Inducers Cytochrome P-450 CYP2C8 Inducers (strength unknown) Cytochrome P-450 CYP2C9 Inducers Cytochrome P-450 CYP2C9 Inducers (strength unknown) Cytochrome P-450 CYP3A Inducers Cytochrome P-450 CYP3A Substrates Cytochrome P-450 CYP3A4 Inducers Cytochrome P-450 CYP3A4 Inducers (strength unknown) Cytochrome P-450 CYP3A4 Substrates Cytochrome P-450 CYP3A5 Substrates Cytochrome P-450 CYP3A7 Substrates Cytochrome P-450 Enzyme Inducers Cytochrome P-450 Substrates Dermatologicals Fused-Ring Compounds Hormones Hormones, Hormone Substitutes, and Hormone Antagonists Hydrocortisone and derivatives Hydroxycorticosteroids Hyperglycemia-Associated Agents Immunosuppressive Agents Intestinal Antiinflammatory Agents Nasal Preparations OAT3/SLC22A8 Substrates Ophthalmological and Otological Preparations Ophthalmologicals Otologicals P-glycoprotein inducers P-glycoprotein substrates Pregnanes Pregnenediones Pregnenes Sensory Organs Steroids Stomatological Preparations Systemic Hormonal Preparations, Excl. Sex Hormones and Insulins Vasoprotectives
ATC-Code	S01CB03 A01AC03 S01BA02 S01CA03 D07AA02 S01BB01 D07XA01 D07BA04 S02CA03 A07EA02 S02BA01 R01AD60 H02AB09 D07CA01 S03CA04 C05AA01
CAS number	50-23-7

Drug Targets

Name	Target Sequence	Pharmacological Action	Actions
Glucocorticoid receptor	MDSKESLTPGREENPSSVLAQERGDVMDFYKTLRGGATVKVSASSPSLAV...	unknown	agonist
Annexin A1	MAMVSEFLKQAWFIENEEQEYVQTVKSSKGGPGSAVSPYPTFNPSSDVAA...	unknown	agonist
Cytochrome P450 3A4	MALIPDLAMETWLLLAVSLVLLYLYGTHSHGLFKKLGIPGPTPLPFLGNI...	unknown	substrate,inducer
Cytochrome P450 3A5	MDLIPNLAVETWLLLAVSLVLLYLYGTRTHGLFKRLGIPGPTPLPLLGNV...	unknown	substrate
Cytochrome P450 3A7	MDLIPNLAVETWLLLAVSLILLYLYGTRTHGLFKKLGIPGPTPLPFLGNA...	unknown	substrate
Cytochrome P450 11B1, mitochondrial	MALRAKAEVCMAVPWLSLQRAQALGTRAARVPRTVLPFEAMPRRPGNRWL...	unknown	substrate
Cytochrome P450 11B2, mitochondrial	MALRAKAEVCVAAPWLSLQRARALGTRAARAPRTVLPFEAMPQHPGNRWL...	unknown	substrate
Cytochrome P450 2C8	MEPFVVLVLCLSFMLLFSLWRQSCRRRKLPPGPTPLPIIGNMLQIDVKDI...	unknown	inducer
Aldo-keto reductase family 1 member D1	MDLSAASHRIPLSDGNSIPIIGLGTYSEPKSTPKGACATSVKVAIDTGYR...	unknown	substrate
3-oxo-5-alpha-steroid 4-dehydrogenase 2	MQVQCQQSPVLAGSATLVALGALALYVAKPSGYGKHTESLKPAATRLPAR...	unknown	substrate
11-beta-hydroxysteroid dehydrogenase type 2	MERWPWPSGGAWLLVAARALLQLLRSDLRLGRPLLAALALLAALDWLCQR...	unknown	substrate
11-beta-hydroxysteroid dehydrogenase 1	MAFMKKYLLPILGLFMAYYYYSANEEFRPEMLQGKKVIVTGASKGIGREM...	unknown	substrate
Cytochrome P450 2A6	MLASGMLLVALLVCLTVMVLMSVWQQRKSKGKLPPGPTPLPFIGNYLQLN...	unknown	inducer
Cytochrome P450 1B1	MGTSLSPNDPWPLNPLSIQQTTLLLLLSVLATVHVGQRLLRQRRRQLRSA...	unknown	inducer
Cytochrome P450 2B6	MELSVLLFLALLTGLLLLLVQRHPNTHDRLPPGPRPLPLLGNLLQMDRRG...	unknown	inducer
Cytochrome P450 2C9	MDSLVVLVLCLSCLLLLSLWRQSSGRGKLPPGPTPLPVIGNILQIGIKDI...	unknown	inducer
Cytochrome P450 2C19	MDPFVVLVLCLSCLLLLSIWRQSSGRGKLPPGPTPLPVIGNILQIDIKDV...	unknown	inducer
Sex hormone-binding globulin	MESRGPLATSRLLLLLLLLLLRHTRQGWALRPVLPTQSAHDPPAVHLSNG...	unknown	binder
Corticosteroid-binding globulin	MPLLLYTCLLWLPTSGLWTVQAMDPNAAYVNMSNHHRGLASANVDFAFSL...	unknown	binder
ATP-dependent translocase ABCB1	MDLEGDRNGGAKKKNFFKLNNKSEKDKKEKKPTVSVFSMFRYSNWLDKLY...	unknown	substrate,inducer
Solute carrier organic anion transporter family member 1A2	MGETEKRIETHRIRCLSKLKMFLLAITCAFVSKTLSGSYMNSMLTQIERQ...	unknown	inhibitor
Organic anion transporter 3	MTFSEILDRVGSMGHFQFLHVAILGLPILNMANHNLLQIFTAATPVHHCR...	unknown	substrate
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Drug Info/Drug Targets: DrugBank 3.0: a comprehensive resource for 'omics' research on drugs. Knox C, Law V, Jewison T, Liu P, Ly S, Frolkis A, Pon A, Banco K, Mak C, Neveu V, Djoumbou Y, Eisner R, Guo AC, Wishart DS. Nucleic Acids Res. 2011 Jan; 39 (Database issue):D1035-41. | PMID:21059682

Related Resource References

Resource Name	Reference
Pharos	CHEMBL389621
PubChem	5754
ChEMBL	CHEMBL389621
ChEBI	CHEBI:17650
CCDC/CSD	ZZZPNG01, ZZZPNG03, GOGQEZ, CORTMS01, COWNEI, CORTMS, ZZZPNG02, CORTPY, SACWAY01, SACWAY, ZZZPNG04
COD	1559402