HIS

HISTIDINE

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is present as a standalone ligand in 100 entries

as a non-polymer is covalently linked to polymer or other heterogen groups 7 entries

is present in a polymer sequence 214,902 entries

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Chemical Component Summary
Name	HISTIDINE
Identifiers	(2S)-2-amino-3-(1H-imidazol-3-ium-4-yl)propanoic acid
Formula	C₆ H₁₀ N₃ O₂
Molecular Weight	156.162
Type	L-PEPTIDE LINKING
Isomeric SMILES	c1c([nH+]c[nH]1)C[C@@H](C(=O)O)N
InChI	InChI=1S/C6H9N3O2/c7-5(6(10)11)1-4-2-8-3-9-4/h2-3,5H,1,7H2,(H,8,9)(H,10,11)/p+1/t5-/m0/s1
InChIKey	HNDVDQJCIGZPNO-YFKPBYRVSA-O

Chemical Details
Formal Charge	1
Atom Count	21
Chiral Atom Count	1
Bond Count	21
Aromatic Bond Count	5

Drug Info: DrugBank

DrugBank ID	DB00117
Name	Histidine
Groups	investigational nutraceutical
Description	An essential amino acid that is required for the production of histamine.
Synonyms	Histidine monohydrochloride monohydrate Copper histidine Histidina Histidine (S)-α-amino-1H-Imidazole-4-propanoic acid L-(−)-histidine L-Histidin (S)-4-(2-Amino-2-carboxyethyl)imidazole (S)-alpha-amino-1H-Imidazole-4-propanoic acid L-Histidine (S)-alpha-Amino-1H-imidazole-4-propionic acid HIS (S)-a-Amino-1H-imidazole-4-propanoic acid
Brand Names	4.25% Travasol Amino Acid Injection With Electrolytes In 10% Dextrose Premasol - sulfite-free (Amino Acid) Aminosyn-PF 10% FreAmine III Travasol E Renamin (amino Acids) Injection 5% Travasol Amino Acid Injection Without Electrolytes In 20% Dextrose ProcalAmine 2.5% Travasol Amino Acid Injection Without Electrolytes In 10% Dextrose Quickmix Aminosyn Sulfite Free Travasol 2.5% Travasol Amino Acid Injection With Electrolytes In 10% Dextrose Trepoxen-250 Olimel 3.3% E Aminosyn RF Injection Clinisol Primene 10%-liq IV 4.25% Travasol Amino Acid Injection With Electrolytes In 5% Dextrose Quickmix Aminosyn II with Electrolytes Smofkabiven Vamin N Smofkabiven Extra Nitrogen Electrolyte Free 4.25%trav. Amino Acid InJ.W.O.elect.5%dext. Periolimel 2.5% E 2.5%travasol Amino Acid InJ.W.eleC.W.25%dex Plenamine Aminosyn 5% RenAmin 2.5% Travasol Amino Acid Injection With Electrolytes In 10% Dextrose Clinimix 2.75% Travasol Amino Acid Injection With Electrolytes In 25% Dextrose Quickmix Primene 10% Novamine Aminosyn II 7% M In 10% Dextrose(dual Chamber) Perikabiven Olimel 5.7% E 2.75% Travasol Amino Acid Injection With Electrolytes In 5% Dextrose Quickmix 2.75%travasol Amino Acid InJ.W.eleC.W.5%dex. Aminosyn RF Essepna 4.25% Travasol Amino Acid Injection Without Electrlytes In 10% Dextrose 5% Travasol Amino Acid Injection Without Electrolytes In 25% Dextrose 4.25% Travasol Amino Acid Injection With Electrolytes In 25% Dextrose Aminosyn 10% W Electrolytes Aminosyn Aminosyn II 5% Inj Olimel 4.4% Aminosyn II Aminosyn II in Dextrose HepatAmine Aminosyn II 7% With 10% Dextrose 4.25% Travasol Amino Acid Injection Without Electrolytes In 20% Dextrose Quick Mix 2.5% Travasol Aa With Electrolytes With 25% Dextrose Injec Travasol Amino Acid Inj 8.5% 8.5% Freamine III 4.25% Travasol Amino Acid Injection With Electrolytes In 20% Dextrose Quickmix CAREDO Treating Periodontitis Toothpastes 100g Aminosyn 7% Smofkabiven Peripheral 4.25% Travasol Amino Acid Injection With Electrolytes In 20% Dextrose Aminosyn II 8.5% Injection Clinimix 2.5% Travasol Aa Without Electrolytes In 10% Dextrose Injec Olimel 4.4% E Travasol Amino Acid Inj 5.5% Olimel 5.7% Nephramine Liq IV 2.75% Travas. Amino Acid InJ.W.elecw.25%dex Synthamin Aminosyn 8.5% Vamin 18 Electrolyte-free Smofkabiven Extra Nitrogen 4.25% Travasol Amino Acid Without Electrolytes In 5% Dextrose Quickmix Aminosyn II 8.5% With 50% Dextrose Nutrineal Pd4 Trepoxicam-7.5 Aminosyn II with Electrolytes in Dextrose with Calcium Aminosyn II In Dextrose Injection Aminosyn II 8.5% M In 20% Dextrose (dual Chamber) Primene Smofkabiven Electrolyte Free Aminosyn HF 4.25% Amino Acid Injection Without Electrolytes In 20% Dextrose Quickmix Travasol Inj Without Electrolytes 8.5% Kabiven 20% Prosol Hepatasol Travasol Inj Without Electrolytes 5.5% Aminosyn-PF Aminosyn II and Dextrose Aminosyn 3.5% M ProSol NephrAmine Aminosyn II 7% Injection Clinimix FreAmine HBC Aminosyn 8.5% Injection With Electrolytes Aminosyn II 7% With 50% Dextrose Aminosyn II 10% With Electrolytes 5% Travasol Amino Acid Injection With Electrolytes In 20% Dextrose Aminosyn-PF 7% Clinimix E TrophAmine Olimel 7.6% Olimel 7.6% E 4.25% Travasol Amino Acid Injection Without Electrolytes In 25% Dextrose 4.25%travasol Amino Acid InJ.W.elecw.5%dex.
Indication	The actions of supplemental L-histidine are entirely unclear. It may have some immunomodulatory as well as antioxidant activity. L-histidine may be indicated for use in some with rheumatoid arthritis. It is not indicated for treatment of anemia or uremia or for lowering serum cholesterol.
Categories	Amino Acids Amino Acids, Cyclic Amino Acids, Essential Amino Acids, Peptides, and Proteins Dietary Supplements Proteinogenic Amino Acids Supplements
CAS number	71-00-1

Drug Targets

Name	Target Sequence	Pharmacological Action	Actions
Histidine decarboxylase	MMEPEEYRERGREMVDYICQYLSTVRERRVTPDVQPGYLRAQLPESAPED...	unknown
Histidine--tRNA ligase, cytoplasmic	MAERAALEELVKLQGERVRGLKQQKASAELIEEEVAKLLKLKAQLGPDES...	unknown
Sodium-coupled neutral amino acid transporter 3	MEAPLQTEMVELVPNGKHSEGLLPVITPMAGNQRVEDPARSCMEGKSFLQ...	unknown
Histidine ammonia-lyase	MPRYTVHVRGEWLAVPCQDAQLTVGWLGREAVRRYIKNKPDNGGFTSVDD...	unknown
Monocarboxylate transporter 10	MVLSQEEPDSARGTSEAQPLGPAPTGAAPPPGPGPSDSPEAAVEKVEVEL...	unknown	substrate,inhibitor

Drug Info/Drug Targets: DrugBank 3.0: a comprehensive resource for 'omics' research on drugs. Knox C, Law V, Jewison T, Liu P, Ly S, Frolkis A, Pon A, Banco K, Mak C, Neveu V, Djoumbou Y, Eisner R, Guo AC, Wishart DS. Nucleic Acids Res. 2011 Jan; 39 (Database issue):D1035-41. | PMID:21059682