HQE

benzene-1,4-diol

Find entries where: HQE

is present as a standalone ligand in 7 entries

as a non-polymer is covalently linked to polymer or other heterogen groups 4 entries

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Chemical Component Summary
Name	benzene-1,4-diol
Identifiers	benzene-1,4-diol
Formula	C₆ H₆ O₂
Molecular Weight	110.111
Type	NON-POLYMER
Isomeric SMILES	c1cc(ccc1O)O
InChI	InChI=1S/C6H6O2/c7-5-1-2-6(8)4-3-5/h1-4,7-8H
InChIKey	QIGBRXMKCJKVMJ-UHFFFAOYSA-N

Chemical Details
Formal Charge	0
Atom Count	14
Chiral Atom Count	0
Bond Count	14
Aromatic Bond Count	6

Drug Info: DrugBank

DrugBank ID	DB09526
Name	Hydroquinone
Groups	approved investigational
Description	Hydroquinone is a topical lightening product found in OTC products, and is used to correct skin discoloration associated with disorders of hyperpigmentation including melasma, post-inflammatory hyperpigmention, sunspots, and freckles. It can be used alone, but is more frequently found in combination with other agents such as alpha-hydroxy acids, corticosteroids, retinoids, or sunscreen. Hydroquinone has come under scrutiny due to several complications associated with its use, including dermal irritation, exogenous onchronosis, and carginogenicity. As a result of these concerns, hydroquinone has been banned in the EU and UK.
Synonyms	benzene-1,4-diol Quinol 1,4-dihydroxybenzene p-Benzenediol 1,4-benzenediol Hydroquinone p-Hydroquinone p-hydroxyphenol 4-Hydroxyphenol
Brand Names	Hydroquinone 4% / Tretinoin 0.025% / Triamcinolone Acetonide 0.025% Esoterica Scented-fortified With Sunscreen Condition and Enhance System Travel-size Non-surgical Scarlight MD Corrector 2 MELAMIX Skin Lightener and Blending HQ Plus Brightening Cream VI Derm Continuum Unifying Lotion I Obagi Medical - Nu-Derm System - Normal to Dry - Skin Transformation Kit Nu-derm System Normal-oily Skin Transformation Trial 141055 Hydroquinone 6% Neostrata Canada Hq Plus Cream SH18 Ultra Harmonie Carrot Beauty Clear-N-Smooth Super-Ultimate Clear-N-Smooth UltraMax NU-DERM System NORMAL-Oily SKIN TRANSFORMATION MD Acne Medicated Dark Spot Remover Triderma Exence White Total White Brightening Hyaluronic Acid Sodium Salt 1% / Hydroquinone 6% Clear-N-Smooth Ultimate Eldopaque Forte Crm 4% Meaningful Beauty Dark Spot Correcting Treatment Drula Fade Cream Superforte Medicated Essential Fade Complex I-max Lightening L Idole Intense Skinprint ClearTone with 2% Hydroquinone Obagi Topiclear Topiclear Lemon Divine Derrier Skin Bleaching cream Hydrocortisone 0.5% / Hydroquinone 6% / Tretinoin 0.025% Jouvence Crm 2% Nu-derm Starter Set Normal-dry Skin Transformation System OBAGI-C RX System NORMAL-DRY SKIN INTERVENTION Ambi Fade Normal Skin Palmer's Skin Success Fade Cream-normal Skin NU-DERM CLEAR Skin Bleaching and Corrector Nu-derm System Normal-dry Skin Transformation 141030 Hydroquinone 8% Porcelana Night Skin Lightening Even Tone Night Treatment Nu-derm System Normal-oily Skin Transformation Perrigo Hydroquinone with sunscreens Lustra-AF Alumier MD Lightening Esoterica Facial Cream Hydroquinone 8% / Tretinoin 0.025%. NeoCeuticals Post Acne Fade ELASTIDERM DECOLLETAGE SKIN LIGHTENING COMPLEX Chest and Neck SH 18 Whitening Superlightener Obagi Nu-Derm Sunfader Idole Black Fade Dark Spots Daytime Treatment Othine Skin Bleach Topiclear Cocoa Butter beauty Top White Lightening HQ Spot Nadinola Skin Discoloration Fade Cream-S.C.f Rodan and Fields Skin Lightening Treatment Lustra AF CONDITION AND ENHANCE BLENDER Skin Lightener and Blending Porcelana Medicated Fade Crm Sunscreen Fmla Palmer's Skin Success Fade Cream-for Dry Skn Seequin 2 African Gold Skin Discoloration Fade Crm 2% Hot Movate Unblemish Regimen for Acne and Post Acne Marks Nadinola Skin FadeExtra Rodan & Fields Proactiv Solution: Skin Lightening Lotion Borba Age Defying Skin Lightening Spot Treatment Black Opal Advanced Dual Phase Fade Creme Aclaro Hydroquinone Dermisa Skin Fade Vitamin C infused Aclaro PD Hydroquinone REVERS Lightening Regimen for the Appearance of Stubborn Dark Marks, Patches and Age Spots Travel Size Olivia Quido Skincare Blemish Eraser Balancer Eldopaque Crm 2% Dr. Throwers Pbc No. 1 AMBI Fade Oily Skin Crusader Skin Lightening Hydroquinone 8%. Nuderm Sunfader Nuquin Hp Pigment Zarina Skin Lightening Cream With Sunscreening Filter Differin Dark Spot Correcting Serum NU-DERM BLENDER Skin Lightener and Blending ZO MEDICAL MELAMIN-C Skin Bleaching and Correcting with Vitamin C Hydroquinone Advanced Skin Lightening Serum 141016 Hydrocortisone 0.5% / Hydroquinone 4% / Tretinoin 0.025% Hydrocortisone 2.5% / Hydroquinone 4% / Tretinoin 0.025%, AMBI Fade Normal Skin Movate Skin Lightening Lemon Black Opal Advance Dual Complex Fade Gel Glytone skin bleaching fading Hydrocortisone 1% / Hydroquinone 8% / Tretinoin 0.05% Porcelana Skin Lightening Nighttime Hydration Clarite 4 Topiclear Skin Lightening Glyquin Xm Continuum Unifying Lotion II Ultra Glow Fade Dark Spot Lightening Cream Bright Malika and Khadija Brightening Spot Treatment Proactiv Solution Dark Spot Corrector SLMD Skincare by Sandra Lee, M.D. - Dark Spot Fix Proactiv Skin Lightening Top White Skin Lightening NeoStrata HQ Skin Lightening Gold Cosmetics Bleach Cream Silver Erfa Hydroquinone Hydroquinone 6% /tretinoin 0.05% Melpaque HP Idole Lemon Skin Lightening Accelerator Pack Hydroquinone 8% African Formula Black PCA Skin Intensive Pigment Eraser Nu-derm Travel Set Normal/dry Skin Transformation System Black and White Skin Bleach Melquin 3 Glytone Skin Lightening Celazome Fade Shades Lightening Cream w/ Glycolic Acid Clear-N-Smooth Unblemish REVERSE Lightening Regimen for the Appearance of Stubborn Dark Marks, Patches and Age Spots Porcelana Skin Lightening Daytime Protection Sunvanish Topiclear Paris Creme Blanchissante - Crm 2% Vivant True Tone Forte Phaze 13 Light N' Block Pigment Cream Drula Fade Cream Normal-medicated Clear-N-Smooth PLUS Skin Lightening Treatment Glytone Dark Spot Corrector Gold Cosmetics Bleach Cream Forte MELAMIN Skin Bleaching and Correcting Hydroquinone Proactiv Advanced Dark Spot Correcting Serum Pharmaskincare Parfait Lightening Serum Unblemish Dermatologist Developed Spot Fading Toner Olivia Quido Blemish Eraser Gold Cosmetics Adi Clear Hydrocortisone 0.5% / Hydroquinone 6% Seequin 4 Ultraquin 4% Hydroquinone Cream With Sunscreens Dolly Intense Lightening ZO Skin Health Pigment Control Creme Hydroquinone Eldoquin Forte Nadinola Skin Fade for Oily Skin LumaSilk Emulsion Level 02 Accelerated Dark Spot Corrector Piona Hydroquinone 4% / Tretinoin 0.025% Solaquin Clear Essence Medicated Fade Cream Neova Complex HQ Plus OLIVIA QUIDO FIRM and FADE II New York Fair and Lovely Teatrical Skin Lightening Skin Lightener African Formula Carrot Ambi Skincare Normal Skin Fade Meditowel Illuminating Skin Brightening Artra Skin Tone for Normal Skin Clear Essence Advance Complex Fade Gel Metasol ZO Skin Health Pigment Control Plus Blending Creme Hydroquinone Idole Natural Organic Teatrical Pro-Aclarant Skin Lightening Ultra Glow Skin Tone Cream Dry Skin Aloe Vera Solaquin Forte OBAGI-C RX system NORMAL-oily SKIN INTERVENTION NU-DERM system NORMAL-DRY SKIN TRANSFORMATION TRIAL Lumipearl Dark Mark Corrector Drula Fade Cream Medium-medicated 141010 Hydroquinone 4% Dual Action Skin Lightener SH18 Skin Lightening 141011 Hydroquinone 6% Obagi - C Ultra Glow Skin Tone Cream Normal Skin Aloe Vera Idole Carrot Clear Essence Skin Lightening Gel Nadinola Skin Fade for Dry Skin EpiQuin Micro Double White Movate Lemon Dermablend Advanced Fade Cream With Sunscreen and Moisturizing Aha Clear Essence Skin Lightening Milk Dermaclair Skin Lightening Nova Complex HQ Medicated Fade Creme with Sunscreen EB5 Age Spot Treatment Medisilke Night gloTriple Action Serum Obagi Medical - Nu-Derm System - Normal to Dry - Skin Transformation Trial Kit Lightener Clear Action Clear-N-Smooth SuperMax Sledgehammer Advanced Lightning Esoterica Daytime with Sunscreen Ambi Fade Oily Skin Movate Skin Lightening Obagi Protocols Clear Dermablend Chromatone Fade Cream With Sunscreen Nu-derm Starter Set Normal-oily Skin Transformation System Exuviance Intense Lightening Complex Recover Lightening Complex with 4% Hydroquinone Fade Dark Spots Nighttime Treatment 141061 Hydrocortisone 0.5% / Hydroquinone 8% / Tretinoin 0.025% Skin Lightening Cream Esoterica Unscented Hydro-Q ZO Skin Health Multi-Therapy Hydroquinone System Glytone Clarifying SunVanish with Sunscreen Topiclear Xtra lemon beauty I-max Lightening 5 Daily Fade Maximum Strength SPF15 Skinprint Recover Lightening Complex with 2% Hydroquinone SYMBA Skin Lightening Advanced Skin Lightening Cream MELAMIN Skin Bleaching and Correcting Skin Lightener Clairissime Clear Complexion Lotion Caro Light Hydroquinone 5% / Tretinoin 0.025% / Triamcinolone Acetonide 0.025% Seequin 4 Ids Esoterica Daytime with Moisturizers and Sunscreen Topiclear Xtra beauty Dr. Lightening Ultra-Potent Facial Precious Beauty Skin Lightening Hyaluronic Acid Sodium Salt 0.5% / Hydroquinone 4% / Tretinoin 0.05% Hydrocortisone 0.5% / Hydroquinone 8% / Tretinoin 0.05% Fading Fluid Ultra-Potent Brightening Serum Hqla ZO Skin Health Pigment Control Program Plus Hydroquinone Pa Plus Advanced Dark Spot Correcting Serum Light The Way Activator Light Esoterica Nighttime with Moisturizers Ambi Extra Skin Discoloration Fade Cream Topiclear Paris Beauty Image MD Lightening Rx Hydroquinone Time Release Neostrata Hq Plus Lightening Cream Ultraplus Skin Lightening Cream - 2% Hydroquinone cream Sh18 Body Fade Creme Maximum Strength Fair and White Dr. Throwers Skin Lightening Moisturizing OBAGI C RX system C CLARIFYING SERUM Enlighten Me NEXT GENERATION Correct Brightening Serum Eldoquin Esoterica Unscented Fortified W.sun Screen NU-DERM SUNFADER Skin Lightener with Sunscreen (SPF 15) PABA FREE Skinprint 3D Clear Peel Artra Skin Tone for Oily Skin NU-DERM system NORMAL-oily SKIN TRANSFORMATION TRIAL 141060 Hydrocortisone 0.5% / Hydroquinone 4% / Tretinoin 0.025% Obagi-C Rx System Normal-dry Skin Intervention CONDITION AND ENHANCE CLEAR Skin Bleaching and Corrector Dermisa Skin Fade Cream Obagi Nu-Derm Porcelana Medicated Fade Cream - Orig. Fmla AMBI Skincare Oily Skin Fade Ultra Glow Skin Tone Cream for Normal Skin Cenovia PLEXADERM Dark Spot Fade Gel Skin Beautifying Milk Hydroquinone 6% Hyperpigmentation Treatment ZO Skin Health Pigment Control plus Brightening Creme Hydroquinone plus Vitamin C Obagi-C Rx System Normal-oily Skin Intervention 141017 Hydrocortisone 0.5% / Hydroquinone 6% / Tretinoin 0.025% Nu-derm System Normal-dry Skin Transformation Trial Hydroquinone 8% / Tretinoin 0.025% LumaSilk Emulsion Level 03 Nadinola Skin Disc.fade Crm for Oily Skin 2% Ultra Glow Skin Tone Cream Oily Skin Aloe Vera Ultra Glow Skin Tone Cream for Oily Skin Nadinola Skin Disc.fade Crm for Dry Skin 2% Artra Skin Tone for Dry Skin Porcelana Day Skin Lightening Hydrocortisone 0.5% / Hydroquinone 8% / Tretinoin 0.025% Vivant True Tone Tri-luma Corrector 4 Drula Fade Cream Extra-medicated Hydrocortisone 0.5% / Hydroquinone 4% / Tretinoin 0.025% Obagi-C Rx system C-Therapy Night Skin Lightening with Vitamins C and E Palmer's Skin Success Fade Cream-for Oily Sk Rejuvaderm medispa fading AGELESS Total Skin Bleaching Serum Hydroquinone Skin Bleaching Agent Oily Skin Multi Complex Fade Esoterica Regular Cream Body Merry Lightening and Whitening Cream Vantex Skin Bleaching Crm W Sunscreen 2% SH18 Caviar Beauty Skin Lightening Complex Ultra Glow Fade with Aloe Vera Viquin Forte With Moisturizing Aha - Crm Conditioning Gel Nadinola Skin Fade for Normal Skin Hqra-otc Idole Skin Lightening Miracle Fade Desoximetasone 0.05% / Hydroquinone 6% / Tretinoin 0.05% Brighten Lightening Hydroquinone 4% Vividly Brilliant Perfecting 141067 Hydroquinone 8% Melquin Hp Idole Beauty Derma Lightening Topiclear Carrot Condition and Enhance System Full-size Non-surgical Hydroquinone Glytone Clarifying Topiclear Cocoa Butter Alphaquin HP Advanced Dual Complex Fade Maximum Strength Plus Spotfade Dark Spot Wand Epiquin Micro eB5 Age Sport Formula Pharmaskincare Serum Skin Lightening Crusader Ultra Skin Lightening OBAGI-C Rx system C-CLARIFYING SERUM NORMAL TO oily SKIN LIGHTENING SERUM WITH VITAMIN C Idole Natural Organic Skin Lightening Esoterica Sunscreen Fade Cream OLIVIA QUIDO FIRM and FADE I Banishing Cream Metasol Skin Lightening Corrector Light Cicatricure Skin Lightening Sunbalance BEST Age Spot Remover Restoration Serum Epione Hydroquinone 6% / Tretinoin 0.05% / Triamcinolone 0.025% Pure Valley Miracle Age Spot Hydroquinone Skin Bleaching Agent Normal Skin Porcelana 24 Hour Skin Lightening Condition and Enhance System Travel-size Surgical Zo Medical Zo Multi-therapy Hydroquinone System Fade Away Extra Care Movate Carrot Lustra Skinprint ClearTone with 8% Hydroquinone Active 4 African Formula Skin Lightening Skin Lightening Rodan Fields eB5 Age Spot Formula Glytone SunVanish Skin Lightening Dermisa Skin Fade Gold Cosmetics Bleach Cream Hydroquinone with sunscreens Hydrocortisone 0.5% / Hydroquinone 6% / Tretinoin 0.05%
Indication	Hydroquinone is used as an OTC topical lightening agent for disorders of hyperpigmentation including melasma, post-inflammatory hyperpigmention, sunspots and freckles.
Categories	Antioxidants Benzene Derivatives Biological Factors Compounds used in a research, industrial, or household setting Depigmenting Agents Dermatologicals Melanin Synthesis Inhibitor Melanin Synthesis Inhibitors Mutagens Noxae Phenols Protective Agents Radiation-Protective Agents Toxic Actions
ATC-Code	D11AX11
CAS number	123-31-9

Drug Targets

Name	Target Sequence	Pharmacological Action	Actions
Tyrosinase	MLLAVLYCLLWSFQTSAGHFPRACVSSKNLMEKECCPPWSGDRSPCGQLS...	unknown	inhibitor
Cysteinyl leukotriene receptor 1	MDETGNLTVSSATCHDTIDDFRNQVYSTLYSMISVVGFFGNGFVLYVLIK...	unknown	activator
Lysosomal alpha-glucosidase	MGVRHPPCSHRLLAVCALVSLATAALLGHILLHDFLLVPRELSGSSPVLE...	unknown	product of
Serum albumin	MKWVTFISLLFLFSSAYSRGVFRRDAHKSEVAHRFKDLGEENFKALVLIA...	unknown

Drug Info/Drug Targets: DrugBank 3.0: a comprehensive resource for 'omics' research on drugs. Knox C, Law V, Jewison T, Liu P, Ly S, Frolkis A, Pon A, Banco K, Mak C, Neveu V, Djoumbou Y, Eisner R, Guo AC, Wishart DS. Nucleic Acids Res. 2011 Jan; 39 (Database issue):D1035-41. | PMID:21059682

Related Resource References

Resource Name	Reference
Pharos	CHEMBL537
PubChem	785
ChEMBL	CHEMBL537
ChEBI	CHEBI:17594
CCDC/CSD	BATRET, CPFEHQ, CIRWEG, AXILUQ, EBILUX, BOKHUG, CEFDOG, COHWIF01, CISCOW, CAKZEV, DOMBEN, BIRQUO, EDAYUG, COZZIB, EDAYEQ, BAVKOA, CABWAD, COHWIF03, ABORAM, COZZOH, BAMZUN01, ACESIL, BAMZUN, AVEKER, EBIMEI, COHWIF02, BUSPAG, BZMETD, EKESIY04, EKESIY05, DIZCEV, DAMPOZ, DAMPOZ01, EKESIY01, EKESIY02, BAMZUN02, EKESIY03, EKESIY06, EKESAQ02, EKESAQ01, ABOQUF, BACRAB, CIPLES, CARWUP, BAMZUN03, COHWIF, CARWUP02, CARWUP01, AVEKIY
COD	2100714, 2100715, 2100716, 2100717, 2211791, 2103388, 2204577, 2100228, 2100231

RCSB PDB Core Operations are funded by the U.S. National Science Foundation (DBI-2321666), the US Department of Energy (DE-SC0019749), and the National Cancer Institute, National Institute of Allergy and Infectious Diseases, and National Institute of General Medical Sciences of the National Institutes of Health under grant R01GM157729.

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HQE

benzene-1,4-diol

Chemical Component Summary

Chemical Details

Drug Info: DrugBank

Drug Targets

Related Resource References