HSM

HISTAMINE

Find entries where: HSM

is present as a standalone ligand in 42 entries

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Chemical Component Summary
Name	HISTAMINE
Identifiers	2-(1H-imidazol-4-yl)ethanamine
Formula	C₅ H₉ N₃
Molecular Weight	111.145
Type	NON-POLYMER
Isomeric SMILES	c1c(nc[nH]1)CCN
InChI	InChI=1S/C5H9N3/c6-2-1-5-3-7-4-8-5/h3-4H,1-2,6H2,(H,7,8)
InChIKey	NTYJJOPFIAHURM-UHFFFAOYSA-N

Chemical Details
Formal Charge	0
Atom Count	17
Chiral Atom Count	0
Bond Count	17
Aromatic Bond Count	5

Drug Info: DrugBank

DrugBank ID	DB05381
Name	Histamine
Groups	approved investigational
Description	A depressor amine derived by enzymatic decarboxylation of histidine. It is a powerful stimulant of gastric secretion, a constrictor of bronchial smooth muscle, a vasodilator, and also a centrally acting neurotransmitter.
Synonyms	2-(4-imidazolyl)ethylamine beta-aminoethylimidazole beta-aminoethylglyoxaline 4-imidazoleethylamine Histamine phosphate Histamine 5-imidazoleethylamine 1H-Imidazole-4-ethanamine Histamine dihydrochloride
Brand Names	Arthritis Pain Relief Arthritis Pain Relief Cream Histatrol Glucosamine Cream EXTRA STRENGTH Midalgan MUSCLESHOK Back Pain Rematex Histamine Phosphate Injection USP, 1mg/ml Arthrocare Lotion DR. MIKES Ponos Pain Relief Cream Roll-On Bakers Best Arthritis Pain Relief Hand and Wrist Pain Cream Positive Skin Test Control-histamine Simanix Arthritis Relief Ceplene HAVASU HEMP Soothing Pain Relief Rub AMINO ACTIVE Topical Analgesic Cream Pain Relieving Arthritis Royal Labs Hemp Recover TerraFreeze Pain Relief Positive Skin Test Control - Histamine Histamine DHCl 0.10 Percent and Menthol 2 Percent ActivOn Ultra Strength Arthritis Australian Dream Back Pain MUSCLESHOK Sport Md Science Cannabidiol Camphomex Dr. Freds MIRACLE RUB Histamine DHCl 0.10 Percent Australian Dream Pain Relieving Arthritis Histamine Phosphate Injection USP Liq Sc Australian Dream Hand and Wrist Pain Australian Dream Carpal Tunnel Pain ROPANA Pain Relief Cream Raging Kakapo Pain Relieve Walgreens Arthritis Pain Relief Cream Abee Med REVIVE SCIENCE Natural Hemp Pain Relief Rub Mancore Muscle Mend Roll-ON Pain Reliever CVS Arthritis Pain Relief Alo Therapeutic Massage Histamine Positive Skin Test Control Minted Leaf Odorless Pain Relief Md Science Cannabigerol PainMD Max Alo Therapeutic Massage Pain Relieving MINTED LEAF Odorless Histamine DHCl Pain Relief and Hemp Extract BAKERS BEST Arthritis Pain Relief Cream with Hemp and Lavender Ponos Natural Pain Relief Bakers Best Arthritis Pain Relief with Hemp Seed
Indication	Histamine phosphate is indicated as a diagnostic aid for the evaluation of gastric acid secretory function.
Categories	Adjuvants, Immunologic Amines Antineoplastic and Immunomodulating Agents Autacoids Biogenic Amines Biogenic Monoamines Biological Factors Cytochrome P-450 CYP3A Inhibitors Cytochrome P-450 Enzyme Inhibitors Diagnostic Agents Ethylamines Gastric Function Histamine Agents Histamine Agonists Imidazoles Inflammation Mediators Neurotransmitter Agents OCT1 substrates OCT2 Inhibitors OCT2 Substrates Other Diagnostics Tests for Gastric Secretion
ATC-Code	L03AX14 V04CG03
CAS number	51-45-6

Drug Targets

Name	Target Sequence	Pharmacological Action	Actions
Histamine H1 receptor	MSLPNSSCLLEDKMCEGNKTTMASPQLMPLVVVLSTICLVTVGLNLLVLY...	unknown	agonist
Histamine H2 receptor	MAPNGTASSFCLDSTACKITITVVLAVLILITVAGNVVVCLAVGLNRRLR...	unknown	agonist
Histamine H3 receptor	MERAPPDGPLNASGALAGEAAAAGGARGFSAAWTAVLAALMALLIVATVL...	unknown	agonist
Histamine H4 receptor	MPDTNSTINLSLSTRVTLAFFMSLVAFAIMLGNALVILAFVVDKNLRHRS...	unknown	agonist
Synaptic vesicular amine transporter	MALSELALVRWLQESRRSRKLILFIVFLALLLDNMLLTVVVPIIPSYLYS...	unknown
Histamine N-methyltransferase	MASSMRSLFSDHGKYVESFRRFLNHSTEHQCMQEFMDKKLPGIIGRIGDT...	unknown	substrate
Solute carrier family 22 member 2	MPTTVDDVLEHGGEFHFFQKQMFFLLALLSATFAPIYVGIVFLGFTPDHR...	unknown	substrate,inhibitor
Solute carrier family 22 member 1	MPTVDDILEQVGESGWFQKQAFLILCLLSAAFAPICVGIVFLGFTPDHHC...	unknown
Solute carrier family 22 member 3	MPSFDEALQRVGEFGRFQRRVFLLLCLTGVTFAFLFVGVVFLGTQPDHYW...	unknown	inhibitor
Solute carrier family 22 member 5	MRDYDEVTAFLGEWGPFQRLIFFLLSASIIPNGFTGLSSVFLIATPEHRC...	unknown	inhibitor
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Drug Info/Drug Targets: DrugBank 3.0: a comprehensive resource for 'omics' research on drugs. Knox C, Law V, Jewison T, Liu P, Ly S, Frolkis A, Pon A, Banco K, Mak C, Neveu V, Djoumbou Y, Eisner R, Guo AC, Wishart DS. Nucleic Acids Res. 2011 Jan; 39 (Database issue):D1035-41. | PMID:21059682