HWL

Flavoxate

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Chemical Component Summary
Name	Flavoxate
Synonyms	2-piperidin-1-ylethyl 3-methyl-4-oxidanylidene-2-phenyl-chromene-8-carboxylate
Identifiers	2-piperidin-1-ylethyl 3-methyl-4-oxidanylidene-2-phenyl-chromene-8-carboxylate
Formula	C₂₄ H₂₅ N O₄
Molecular Weight	391.46
Type	NON-POLYMER
Isomeric SMILES	CC1=C(Oc2c(cccc2C(=O)OCCN3CCCCC3)C1=O)c4ccccc4
InChI	InChI=1S/C24H25NO4/c1-17-21(26)19-11-8-12-20(23(19)29-22(17)18-9-4-2-5-10-18)24(27)28-16-15-25-13-6-3-7-14-25/h2,4-5,8-12H,3,6-7,13-16H2,1H3
InChIKey	SPIUTQOUKAMGCX-UHFFFAOYSA-N

Chemical Details
Formal Charge	0
Atom Count	54
Chiral Atom Count	0
Bond Count	57
Aromatic Bond Count	12

Drug Info: DrugBank

DrugBank ID	DB01148
Name	Flavoxate
Groups	approved
Description	A drug that has been used in various urinary syndromes and as an antispasmodic. Its therapeutic usefulness and its mechanism of action are not clear. It may have local anesthetic activity and direct relaxing effects on smooth muscle as well as some activity as a muscarinic antagonist. [PubChem]
Synonyms	Flavoxate hydrochloride 2-piperidinoethyl 3-methylflavone-8-carboxylate β-piperidinoethyl 3-methylflavone-8-carboxylate Flavoxatum Flavoxate Flavoxato 2-(1-piperidinyl)ethyl 3-methyl-4-oxo-2-phenyl-4H-chromene-8-carboxylate 2-piperidinoethyl 3-methyl-4-oxo-2-phenyl-4H-1-benzopyran-8-carboxylate
Brand Names	Flavoxate PMS-flavoxate Apo-flavoxate Flavoxate Hydrochloride Urispas Urispas Tab 200mg
Indication	For symptomatic relief of dysuria, urgency, nocturia, suprapubic pain, frequency and incontinence as may occur in cystitis, prostatitis, urethritis, urethrocystitis/urethrotrigonitis.
Categories	Agents producing tachycardia Anticholinergic Agents Autonomic Agents Benzopyrans Chromones Drugs for Urinary Frequency and Incontinence Drugs that are Mainly Renally Excreted Flavones Flavonoids Genito Urinary System and Sex Hormones Genitourinary Agents Heterocyclic Compounds, Fused-Ring Muscarinic Antagonists Parasympatholytics Peripheral Nervous System Agents Pyrans Urological Agents Urologicals
ATC-Code	G04BD02
CAS number	15301-69-6

Drug Targets

Name	Target Sequence	Pharmacological Action	Actions
Muscarinic acetylcholine receptor M1	MNTSAPPAVSPNITVLAPGKGPWQVAFIGITTGLLSLATVTGNLLVLISF...	unknown	antagonist
Muscarinic acetylcholine receptor M2	MNNSTNSSNNSLALTSPYKTFEVVFIVLVAGSLSLVTIIGNILVMVSIKV...	unknown	antagonist

Drug Info/Drug Targets: DrugBank 3.0: a comprehensive resource for 'omics' research on drugs. Knox C, Law V, Jewison T, Liu P, Ly S, Frolkis A, Pon A, Banco K, Mak C, Neveu V, Djoumbou Y, Eisner R, Guo AC, Wishart DS. Nucleic Acids Res. 2011 Jan; 39 (Database issue):D1035-41. | PMID:21059682