HYP

4-HYDROXYPROLINE

Created:	1999-07-08
Last modified:	2024-09-27

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10 entries where HYP is found as a standalone ligand370 entries where HYP is found in a polymer sequence

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Chemical Details
Formal Charge	0
Atom Count	18
Chiral Atom Count	2
Bond Count	18
Aromatic Bond Count	0

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Chemical Component Summary
Name	4-HYDROXYPROLINE
Synonyms	HYDROXYPROLINE
Systematic Name (OpenEye OEToolkits)	(2S,4R)-4-hydroxypyrrolidine-2-carboxylic acid
Formula	C₅ H₉ N O₃
Molecular Weight	131.13
Type	L-PEPTIDE LINKING

Chemical Descriptors
Type	Program	Version	Descriptor
SMILES	ACDLabs	10.04	O=C(O)C1NCC(O)C1
SMILES	CACTVS	3.341	O[CH]1CN[CH](C1)C(O)=O
SMILES	OpenEye OEToolkits	1.5.0	C1C(CNC1C(=O)O)O
Canonical SMILES	CACTVS	3.341	O[C@H]1CN[C@@H](C1)C(O)=O
Canonical SMILES	OpenEye OEToolkits	1.5.0	C1[C@H](CN[C@@H]1C(=O)O)O
InChI	InChI	1.03	InChI=1S/C5H9NO3/c7-3-1-4(5(8)9)6-2-3/h3-4,6-7H,1-2H2,(H,8,9)/t3-,4+/m1/s1
InChIKey	InChI	1.03	PMMYEEVYMWASQN-DMTCNVIQSA-N

Drug Info: DrugBank

DrugBank ID	DB08847
Name	Hydroxyproline
Groups	experimental
Description	Hydroxyproline is a neutral heterocyclic protein amino acid. It is found in collagen and as such it is common in many gelatin products. Hydroxyproline is mostly used as a diagnostic marker of bone turnover and liver fibrosis. Therapeutically, hydroxyproline is being studied as an an experimental medicine but is approved in France as a combination topical gel product called Cicactive for small, superficial wounds.
Synonyms	trans-L-Hydroxyproline trans-4-Hydroxy-L-proline Hydroxyproline
Brand Names	Gongjinhyang Mi Luxury Base Ageless Foundation 23 Isaknox Timeless Essence Foundation 21 Cathycat Chewy CREAM FOUNDATION SPF23 PA WHITENING ANTI WRINKLE 23 Ohui Skin Science Age Recovery Cell Lab Essence Ohui Skin Science Age Recovery Cell Lab Ohui Skin Science Age Recovery Cell Lab Eye O Hui Wrinkle Science Wrinkle Repair Isa Knox Tervina Repair Foundation Bb Soo Rye Han Dabityun Jiyun Foundation 21 Sooryehan Onbit Essence Foundation 25 Ohui Skin Science Age Recovery Cell Lab Pramin Ohui The First Cell Revolution Age Control Sun Block Sooryehan Onbit Lifting Base Ouhi Cell Power No 1 Essence The History Of Whoo Gongjinhyang Mi Pact 1 Isaknox Timeless Essence Foundation 23 O Hui Wrinkle Science Deep Wrinkle Treatment Isaknox Ageless Serum Moist Pearl Base Ohui Skin Science Age Recovery Cell-lab Essential Gongjinhyang Mi Luxury Foundation 1 Ouhi Cell Power No 1 Eye Soo Rye Han Dabityoon Jiyoon Foundation 23 Isa Knox Wrinkle Decline Double Effect Rf3 Wrinkle Eye Filler Isa Knox Wrinkle Decline Double Effect Rf3 Wrinkle The History of Whoo Bichup Ja Saeng Essence OHUI Wrinkle Science wrinkle repair eye Isa Knox Ageless Serum Makeup Base 10 Gongjinhyang Mi Luxury Foundation 2 Isaknox Timeless Essence Makeup Base 70 Sooryehan Onbit Essence Foundation 23 The History Of Whoo Gongjinhyang Mi Pact 2 Cathycat Chewy CREAM FOUNDATION SPF23 PA WHITENING ANTI WRINKLE 21 Isa Knox Smart Bb Sun
Indication	Used in France as a combination product for the treatment of small, superficial wounds.
Categories	Amino Acids Amino Acids, Cyclic Amino Acids, Peptides, and Proteins Imino Acids
CAS number	51-35-4

Drug Targets

Name	Target Sequence	Pharmacological Action	Actions
Proton-coupled amino acid transporter 1	MSTQRLRNEDYHDYSSTDVSPEESPSEGLNNLSSPGSYQRFGQSNSTTWF...	unknown

Drug Info/Drug Targets: DrugBank 3.0: a comprehensive resource for 'omics' research on drugs. Knox C, Law V, Jewison T, Liu P, Ly S, Frolkis A, Pon A, Banco K, Mak C, Neveu V, Djoumbou Y, Eisner R, Guo AC, Wishart DS. Nucleic Acids Res. 2011 Jan; 39 (Database issue):D1035-41. | PMID:21059682