IMH
1,4-DIDEOXY-4-AZA-1-(S)-(9-DEAZAHYPOXANTHIN-9-YL)-D-RIBITOL
Find entries where: IMH
is present as a standalone ligand in 21 entries
Chemical Component Summary | |
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Name | 1,4-DIDEOXY-4-AZA-1-(S)-(9-DEAZAHYPOXANTHIN-9-YL)-D-RIBITOL |
Synonyms | Forodesine; Immucillin H |
Identifiers | 7-[(2~{S},3~{S},4~{R},5~{R})-5-(hydroxymethyl)-3,4-bis(oxidanyl)pyrrolidin-2-yl]-3,5-dihydropyrrolo[3,2-d]pyrimidin-4-one |
Formula | C11 H14 N4 O4 |
Molecular Weight | 266.253 |
Type | NON-POLYMER |
Isomeric SMILES | c1c(c2c([nH]1)C(=O)NC=N2)[C@H]3[C@@H]([C@@H]([C@H](N3)CO)O)O |
InChI | InChI=1S/C11H14N4O4/c16-2-5-9(17)10(18)7(15-5)4-1-12-8-6(4)13-3-14-11(8)19/h1,3,5,7,9-10,12,15-18H,2H2,(H,13,14,19)/t5-,7+,9-,10+/m1/s1 |
InChIKey | IWKXDMQDITUYRK-KUBHLMPHSA-N |
Chemical Details | |
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Formal Charge | 0 |
Atom Count | 33 |
Chiral Atom Count | 4 |
Bond Count | 35 |
Aromatic Bond Count | 5 |
Drug Info: DrugBank
DrugBank ID | DB06185 |
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Name | Forodesine |
Groups | investigational |
Description | Forodesine is a highly potent, orally active, rationally designed PNP inhibitor that has shown activity in preclinical studies with malignant cells and clinical utility against T-cell acute lymphoblastic leukemia and cutaneous T-cell lymphoma. Additional preliminary findings support its use for the management of some B-cell malignancies. |
Synonyms |
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Indication | Investigated for use/treatment in lymphoma (non-hodgkin's) and leukemia (lymphoid). |
Categories |
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CAS number | 209799-67-7 |
Drug Targets
Name | Target Sequence | Pharmacological Action | Actions |
---|---|---|---|
Purine nucleoside phosphorylase | MENGYTYEDYKNTAEWLLSHTKHRPQVAIICGSGLGGLTDKLTQAQIFDY... | unknown |
Drug Info/Drug Targets: DrugBank 3.0: a comprehensive resource for 'omics' research on drugs. Knox C, Law V, Jewison
T, Liu P, Ly S, Frolkis A, Pon A, Banco K, Mak C, Neveu V, Djoumbou Y, Eisner R, Guo AC, Wishart DS.
Nucleic Acids Res. 2011 Jan; 39 (Database issue):D1035-41. | PMID:21059682
Related Resource References
Resource Name | Reference |
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Pharos | CHEMBL218291 |
PubChem | 135409409, 5288627, 444499 |
ChEMBL | CHEMBL218291 |
ChEBI | CHEBI:43362 |