JMS

2-[(2,6-dichloro-3-methyl-phenyl)amino]benzoic acid

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is present as a standalone ligand in 5 entries

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Chemical Component Summary
Name	2-[(2,6-dichloro-3-methyl-phenyl)amino]benzoic acid
Synonyms	meclofenamic acid
Identifiers	2-[(2,6-dichloro-3-methyl-phenyl)amino]benzoic acid
Formula	C₁₄ H₁₁ Cl₂ N O₂
Molecular Weight	296.149
Type	NON-POLYMER
Isomeric SMILES	Cc1ccc(c(c1Cl)Nc2ccccc2C(=O)O)Cl
InChI	InChI=1S/C14H11Cl2NO2/c1-8-6-7-10(15)13(12(8)16)17-11-5-3-2-4-9(11)14(18)19/h2-7,17H,1H3,(H,18,19)
InChIKey	SBDNJUWAMKYJOX-UHFFFAOYSA-N

Chemical Details
Formal Charge	0
Atom Count	30
Chiral Atom Count	0
Bond Count	31
Aromatic Bond Count	12

Drug Info: DrugBank

DrugBank ID	DB00939
Name	Meclofenamic acid
Groups	approved vet_approved
Description	A non-steroidal anti-inflammatory agent with antipyretic and antigranulation activities. It also inhibits prostaglandin biosynthesis.
Synonyms	Meclofenamic acid Acide méclofénamique N-(2,6-dichloro-m-tolyl)anthranilic acid N-(3-methyl-2,6-dichlorophenyl)anthranilic acid Meclofenamate Acidum meclofenamicum ácido meclofenámico N-(2,6-dichloro-3-methylphenyl)anthranilic acid Meclofenamate sodium
Brand Names	Meclofenamate Sodium
Indication	For the relief of mild to moderate pain, for the treatment of primary dysmenorrhea and for the treatment of idiopathic heavy menstrual blood loss. Also for relief of the signs and symptoms of acute and chronic rheumatoid arthritis and osteoarthritis.
Categories	Acids, Carbocyclic Agents causing hyperkalemia Agents that produce hypertension Aminobenzoates Analgesics Analgesics, Non-Narcotic Anti-Inflammatory Agents Anti-Inflammatory Agents, Non-Steroidal Anti-Inflammatory Agents, Non-Steroidal (Non-Selective) Antiinflammatory and Antirheumatic Products Antiinflammatory and Antirheumatic Products, Non-Steroids Antiinflammatory Preparations, Non-Steroids for Topical Use Antirheumatic Agents Benzene Derivatives Benzoates Cyclooxygenase Inhibitors Drugs that are Mainly Renally Excreted Enzyme Inhibitors Fenamates Musculo-Skeletal System Nephrotoxic agents Non COX-2 selective NSAIDS OAT1/SLC22A6 inhibitors ortho-Aminobenzoates Peripheral Nervous System Agents Sensory System Agents Thyroxine-binding globulin substrates Topical Products for Joint and Muscular Pain
ATC-Code	M01AG04 M02AA18
CAS number	644-62-2

Drug Targets

Name	Target Sequence	Pharmacological Action	Actions
Prostaglandin G/H synthase 1	MSRSLLLWFLLFLLLLPPLPVLLADPGAPTPVNPCCYYPCQHQGICVRFG...	unknown	inhibitor
Prostaglandin G/H synthase 2	MLARALLLCAVLALSHTANPCCSHPCQNRGVCMSVGFDQYKCDCTRTGFY...	unknown	inhibitor
Arachidonate 5-lipoxygenase	MPSYTVTVATGSQWFAGTDDYIYLSLVGSAGCSEKHLLDKPFYNDFERGA...	unknown	inhibitor
Potassium voltage-gated channel subfamily KQT member 2	MVQKSRNGGVYPGPSGEKKLKVGFVGLDPGAPDSTRDGALLIAGSEAPKR...	unknown	other
Potassium voltage-gated channel subfamily KQT member 3	MGLKARRAAGAAGGGGDGGGGGGGAANPAGGDAAAAGDEERKVGLAPGDV...	unknown	other
Thyroxine-binding globulin	MSPFLYLVLLVLGLHATIHCASPEGKVTACHSSQPNATLYKMSSINADFA...	unknown	substrate
Solute carrier family 22 member 6	MAFNDLLQQVGGVGRFQQIQVTLVVLPLLLMASHNTLQNFTAAIPTHHCR...	unknown	inhibitor
Solute carrier organic anion transporter family member 1C1	MDTSSKENIQLFCKTSVQPVGRPSFKTEYPSSEEKQPCCGELKVFLCALS...	unknown	inhibitor
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Drug Info/Drug Targets: DrugBank 3.0: a comprehensive resource for 'omics' research on drugs. Knox C, Law V, Jewison T, Liu P, Ly S, Frolkis A, Pon A, Banco K, Mak C, Neveu V, Djoumbou Y, Eisner R, Guo AC, Wishart DS. Nucleic Acids Res. 2011 Jan; 39 (Database issue):D1035-41. | PMID:21059682