L8P

({[(2S)-1-(4-amino-2-oxopyrimidin-1(2H)-yl)-3-hydroxypropan-2-yl]oxy}methyl)phosphonic acid

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is present as a standalone ligand in 1 entries

is present in a polymer sequence 2 entries

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Chemical Component Summary
Name	({[(2S)-1-(4-amino-2-oxopyrimidin-1(2H)-yl)-3-hydroxypropan-2-yl]oxy}methyl)phosphonic acid
Synonyms	Cidofovir
Identifiers	[(2S)-1-(4-azanyl-2-oxo-pyrimidin-1-yl)-3-hydroxy-propan-2-yl]oxymethylphosphonic acid
Formula	C₈ H₁₄ N₃ O₆ P
Molecular Weight	279.187
Type	NON-POLYMER
Isomeric SMILES	C1=CN(C(=O)N=C1N)C[C@@H](CO)OCP(=O)(O)O
InChI	InChI=1S/C8H14N3O6P/c9-7-1-2-11(8(13)10-7)3-6(4-12)17-5-18(14,15)16/h1-2,6,12H,3-5H2,(H2,9,10,13)(H2,14,15,16)/t6-/m0/s1
InChIKey	VWFCHDSQECPREK-LURJTMIESA-N

Chemical Details
Formal Charge	0
Atom Count	32
Chiral Atom Count	1
Bond Count	32
Aromatic Bond Count	0

Drug Info: DrugBank

DrugBank ID	DB00369
Name	Cidofovir
Groups	approved
Description	Cidofovir is an injectable antiviral medication employed in the treatment of cytomegalovirus (CMV) retinitis in patients diagnosed with AIDS. It suppresses CMV replication through selective inhibition of viral DNA synthesis.[FDA label] It was manufactured by _Gilead_ and initially approved by the FDA in 1996, but has since been discontinued.[L6223]
Synonyms	[(S)-2-(4-Amino-2-oxo-2H-pyrimidin-1-yl)-1-hydroxymethyl-ethoxymethyl]-phosphonic acid ({[(S)-1-(4-amino-2-oxo-1,2-dihydropyrimidin-1-yl)-3-hydroxypropan-2-yl]oxy}methyl)phosphonic acid (S)-1-[3-Hydroxy-2-(phosphonomethoxy)propyl]cytosine 1-(S)-[3-Hydroxy-2-(phosphonomethoxy)propyl]cytosine Cidofovir anhydrous (S)-1-[3-Hydroxy-2-(phosphonylmethoxy)propyl]cytosine Cidofovirum (S)-HPMPC CDV [[(S)-2-(4-amino-2-oxo-1(2H)-pyrimidinyl)-1-(hydroxymethyl)ethoxy]methyl]phosphonic acid Cidofovir dihydrate Cidofovir (S)-1-(3-Hydroxy-2-phosphonomethoxypropyl)cytosine (S)-(3-(4-amino-2-Oxopyrimidin-1(2H)-yl)-1-hydroxypropan-2-yloxy)methylphosphonic acid 1-[(S)-3-Hydroxy-2-(phosphonomethoxy)propyl]cytosine
Brand Names	Mar-cidofovir Cidofovir Dihydrate Cidofovir Vistide
Indication	For the treatment of CMV retinitis in patients with acquired immunodeficiency syndrome (AIDS)
Categories	Anti-Infective Agents Antiinfectives for Systemic Use Antiviral Agents Antivirals for Systemic Use Cytomegalovirus Nucleoside Analog DNA Polymerase Inhibitor Cytosine Direct Acting Antivirals Drugs that are Mainly Renally Excreted Enzyme Inhibitors Nephrotoxic agents Nucleic Acid Synthesis Inhibitors Nucleosides and Nucleotides Nucleosides and Nucleotides Excl. Reverse Transcriptase Inhibitors OAT1/SLC22A6 inhibitors OAT1/SLC22A6 Substrates Organophosphonates Organophosphorus Compounds Pyrimidines Pyrimidinones
ATC-Code	J05AB12
CAS number	113852-37-2

Drug Targets

Name	Target Sequence	Pharmacological Action	Actions
DNA polymerase catalytic subunit	MFFNPYLSGGVTGGAVAGGRRQRSQPGSAQGSGKRPPQKQFLQIVPRGVM...	unknown	inhibitor
Thymidine phosphorylase	MAALMTPGTGAPPAPGDFSGEGSQGLPDPSPEPKQLPELIRMKRDGGRLS...	unknown	inhibitor
Solute carrier family 22 member 6	MAFNDLLQQVGGVGRFQQIQVTLVVLPLLLMASHNTLQNFTAAIPTHHCR...	unknown	substrate,inhibitor

Drug Info/Drug Targets: DrugBank 3.0: a comprehensive resource for 'omics' research on drugs. Knox C, Law V, Jewison T, Liu P, Ly S, Frolkis A, Pon A, Banco K, Mak C, Neveu V, Djoumbou Y, Eisner R, Guo AC, Wishart DS. Nucleic Acids Res. 2011 Jan; 39 (Database issue):D1035-41. | PMID:21059682