LEU

LEUCINE

Find entries where: LEU

is present as a standalone ligand in 109 entries

as a non-polymer is covalently linked to polymer or other heterogen groups 28 entries

is present in a polymer sequence 221,444 entries

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Chemical Component Summary
Name	LEUCINE
Identifiers	(2S)-2-amino-4-methyl-pentanoic acid
Formula	C₆ H₁₃ N O₂
Molecular Weight	131.173
Type	L-PEPTIDE LINKING
Isomeric SMILES	CC(C)C[C@@H](C(=O)O)N
InChI	InChI=1S/C6H13NO2/c1-4(2)3-5(7)6(8)9/h4-5H,3,7H2,1-2H3,(H,8,9)/t5-/m0/s1
InChIKey	ROHFNLRQFUQHCH-YFKPBYRVSA-N

Chemical Details
Formal Charge	0
Atom Count	22
Chiral Atom Count	1
Bond Count	21
Aromatic Bond Count	0

Drug Info: DrugBank

DrugBank ID	DB00149
Name	Leucine
Groups	investigational nutraceutical
Description	An essential branched-chain amino acid important for hemoglobin formation.
Synonyms	(2S)-2-Amino-4-methylpentanoic acid L-Leuzin Leu L-Leucine (2S)-alpha-2-Amino-4-methylvaleric acid L-Leucine hydrochloride L (S)-Leucine L-Leucin (S)-(+)-Leucine (2S)-alpha-Leucine 2-Amino-4-methylvaleric acid Leucine
Brand Names	2.75%travasol Amino Acid InJ.W.eleC.W.5%dex. Primene 10%-liq IV 2.75% Travas. Amino Acid InJ.W.elecw.25%dex Renamin (amino Acids) Injection Aminosyn 8.5% Injection With Electrolytes Aminosyn 4.25% Travasol Amino Acid Injection With Electrolytes In 20% Dextrose 2.5%travasol Amino Acid InJ.W.eleC.W.25%dex Olimel 5.7% Aminosyn 10% W Electrolytes 4.25% Amino Acid Injection Without Electrolytes In 20% Dextrose Quickmix Travasol E Aminosyn II In Dextrose Injection Olimel 7.6% E ExoSCRT Derma Signal SRLV Vial 2. Diluent Perikabiven Premasol - sulfite-free (Amino Acid) Olimel 3.3% E Vamin N Olimel 4.4% E Aminosyn II 7% M In 10% Dextrose(dual Chamber) Essepna 4.25% Travasol Amino Acid Without Electrolytes In 5% Dextrose Quickmix NephrAmine 4.25% Travasol Amino Acid Injection With Electrolytes In 25% Dextrose Aminosyn II Aminosyn II 8.5% With 50% Dextrose TrophAmine 8.5% Freamine III RenAmin 4.25% Travasol Amino Acid Injection With Electrolytes In 10% Dextrose Aminosyn Sulfite Free Vamin 18 Electrolyte-free Aminosyn 7% 4.25%trav. Amino Acid InJ.W.O.elect.5%dext. Aminosyn II 8.5% M In 20% Dextrose (dual Chamber) HepatAmine Clinimix E 2.75% Travasol Amino Acid Injection With Electrolytes In 5% Dextrose Quickmix 4.25% Travasol Amino Acid Injection Without Electrolytes In 20% Dextrose 4.25% Travasol Amino Acid Injection Without Electrolytes In 25% Dextrose 2.5% Travasol Amino Acid Injection Without Electrolytes In 10% Dextrose Quickmix Nutrineal Pd4 Synthamin Novamine Smofkabiven Extra Nitrogen Aminosyn II 8.5% Injection 5% Travasol Amino Acid Injection Without Electrolytes In 25% Dextrose Aminosyn II in Dextrose Clinimix 2.5% Travasol Aa Without Electrolytes In 10% Dextrose Injec Primene 10% Quick Mix 2.5% Travasol Aa With Electrolytes With 25% Dextrose Injec Kabiven Smofkabiven Peripheral 2.75% Travasol Amino Acid Injection With Electrolytes In 25% Dextrose Quickmix Olimel 4.4% Aminosyn RF 4.25% Travasol Amino Acid Injection With Electrolytes In 20% Dextrose Quickmix Olimel 5.7% E Aminosyn RF Injection BranchAmin 4.25% Travasol Amino Acid Injection Without Electrlytes In 10% Dextrose Olimel 7.6% Aminosyn II 7% With 10% Dextrose Aminosyn II 10% With Electrolytes Aminosyn-PF 7% Aminosyn II 7% Injection Aminosyn-PF 10% ExoSCRT Derma Signal SRLV Vial 1. Lyophilized Travasol Amino Acid Inj 8.5% Aminosyn II with Electrolytes in Dextrose with Calcium Aminosyn HF 20% Prosol Aminosyn II 7% With 50% Dextrose 4.25% Travasol Amino Acid Injection With Electrolytes In 5% Dextrose Quickmix Aminosyn II 5% Inj Travasol 2.5% Travasol Amino Acid Injection With Electrolytes In 10% Dextrose Travasol Amino Acid Inj 5.5% 5% Travasol Amino Acid Injection Without Electrolytes In 20% Dextrose Aminosyn II and Dextrose 4.25%travasol Amino Acid InJ.W.elecw.5%dex. Aminosyn 3.5% M ASCE plus Derma Signal Kit SRLV S Primene Aminosyn II with Electrolytes 5% Travasol Amino Acid Injection With Electrolytes In 20% Dextrose Smofkabiven Extra Nitrogen Electrolyte Free Travasol Inj Without Electrolytes 8.5% Aminosyn 5% Aminosyn 8.5% Aminosyn-PF ProcalAmine Bcaa 4% Inj Plenamine FreAmine HBC Nephramine Liq IV Hepatasol ExoSCRT Derma Signal Kit SRLV Smofkabiven Clinimix ProSol FreAmine III Periolimel 2.5% E 2.5% Travasol Amino Acid Injection With Electrolytes In 10% Dextrose Clinimix Smofkabiven Electrolyte Free Travasol Inj Without Electrolytes 5.5% ASCE plus Derma Signal Kit SRLV Clinisol
Indication	Indicated to assist in the prevention of the breakdown of muscle proteins that sometimes occur after trauma or severe stress.
Categories	Amino Acids Amino Acids, Branched-Chain Amino Acids, Essential Amino Acids, Peptides, and Proteins Dietary Supplements Proteinogenic Amino Acids Supplements
CAS number	61-90-5

Drug Targets

Name	Target Sequence	Pharmacological Action	Actions
Probable leucine--tRNA ligase, mitochondrial	MASVWQRLGFYASLLKRQLNGGPDVIKWERRVIPGCTRSIYSATGKWTKE...	unknown
Leucine carboxyl methyltransferase 2	MGPRSRERRAGAVQNTNDSSALSKRSLAARGYVQDPFAALLVPGAARRAP...	unknown
Leucine carboxyl methyltransferase 1	MATRQRESSITSCCSTSSCDADDEGVRGTCEDASLCKRFAVSIGYWHDPY...	unknown
Leucine--tRNA ligase, cytoplasmic	MAERKGTAKVDFLKKIEKEIQQKWDTERVFEVNASNLEKQTSKGKYFVTF...	unknown
Branched-chain-amino-acid aminotransferase, mitochondrial	MAAAALGQIWARKLLSVPWLLCGPRRYASSSFKAADLQLEMTQKPHKKPG...	unknown
Branched-chain-amino-acid aminotransferase, cytosolic	MKDCSNGCSAECTGEGGSKEVVGTFKAKDLIVTPATILKEKPDPNNLVFG...	unknown
Monocarboxylate transporter 10	MVLSQEEPDSARGTSEAQPLGPAPTGAAPPPGPGPSDSPEAAVEKVEVEL...	unknown	inhibitor
Monocarboxylate transporter 8	MALQSQASEEAKGPWQEADQEQQEPVGSPEPESEPEPEPEPEPVPVPPPE...	unknown	substrate
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Drug Info/Drug Targets: DrugBank 3.0: a comprehensive resource for 'omics' research on drugs. Knox C, Law V, Jewison T, Liu P, Ly S, Frolkis A, Pon A, Banco K, Mak C, Neveu V, Djoumbou Y, Eisner R, Guo AC, Wishart DS. Nucleic Acids Res. 2011 Jan; 39 (Database issue):D1035-41. | PMID:21059682

Related Resource References

Resource Name	Reference
PubChem	7045798, 6106
ChEMBL	CHEMBL291962
ChEBI	CHEBI:57427, CHEBI:15603
CCDC/CSD	CADPEF, CADPAB, CEGKOQ, GOWCAW, FEQYUW, GOWBUP, POVYUV, AXUTIX, DLLEUC02, ZIPCOT01, WAKYAJ, ZIPCOT, URODEL, SETTOB, VUKQAV01, GUQKEK, NOFWUA, HAGZUL, PATPUV, VUKQAV03, VUKQAV02, NOFXEL, NOFXAH, CADLEA, VUKQAV04, VUKQAV05, VUKQAV06, VUKQAV08, VUKQAV09, FITNIF, VUKQAV07, AHOHIQ, GOWBOJ, DLLEUC, KERMUP, YIGMIM, ZINDEI, DLLEUC03, VUKQAV, ZATMUG, ZATJOX, WIPQOE01, ZATNER, SAJYUB, ZATNAN
COD	4501604

RCSB PDB Core Operations are funded by the U.S. National Science Foundation (DBI-2321666), the US Department of Energy (DE-SC0019749), and the National Cancer Institute, National Institute of Allergy and Infectious Diseases, and National Institute of General Medical Sciences of the National Institutes of Health under grant R01GM157729.

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LEU

LEUCINE

Chemical Component Summary

Chemical Details

Drug Info: DrugBank

Drug Targets

Related Resource References