LYS

LYSINE

Find entries where: LYS

is present as a standalone ligand in 178 entries

as a non-polymer is covalently linked to polymer or other heterogen groups 64 entries

is present in a polymer sequence 220,368 entries

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Chemical Component Summary
Name	LYSINE
Identifiers	[(5S)-5-amino-6-hydroxy-6-oxo-hexyl]azanium
Formula	C₆ H₁₅ N₂ O₂
Molecular Weight	147.195
Type	L-PEPTIDE LINKING
Isomeric SMILES	C(CC[NH3+])C[C@@H](C(=O)O)N
InChI	InChI=1S/C6H14N2O2/c7-4-2-1-3-5(8)6(9)10/h5H,1-4,7-8H2,(H,9,10)/p+1/t5-/m0/s1
InChIKey	KDXKERNSBIXSRK-YFKPBYRVSA-O

Chemical Details
Formal Charge	1
Atom Count	25
Chiral Atom Count	1
Bond Count	24
Aromatic Bond Count	0

Drug Info: DrugBank

DrugBank ID	DB00123
Name	Lysine
Groups	nutraceutical approved
Description	Lysine (abbreviated as Lys or K) is an α-amino acid with the chemical formula HO2CCH(NH2)(CH2)4NH2. This amino acid is an essential amino acid, which means that humans cannot synthesize it. Its codons are AAA and AAG. Lysine is a base, as are arginine and histidine. The ε-amino group acts as a site for hydrogen binding and a general base in catalysis. Common posttranslational modifications include methylation of the ε-amino group, giving methyl-, dimethyl-, and trimethyllysine. The latter occurs in calmodulin. Other posttranslational modifications include acetylation. Collagen contains hydroxylysine which is derived from lysine by lysyl hydroxylase. O-Glycosylation of lysine residues in the endoplasmic reticulum or Golgi apparatus is used to mark certain proteins for secretion from the cell.
Synonyms	Lysina Lysine acetate L-Lysin Lysine dihydrate L-Lysine L-2,6-Diaminocaproic acid Lysine monohydrate (S)-α,ε-diaminocaproic acid Lysine acid L-lys (S)-2,6-diaminohexanoic acid Lysine (S)-lysine Lysinum 6-ammonio-L-norleucine Lysine hydrochloride LYS
Brand Names	Olimel 7.6% ProcalAmine 2.5% Travasol Amino Acid Injection With Electrolytes In 10% Dextrose Clinimix Imubolic Travasol Inj Without Electrolytes 8.5% Clinimix E Essepna 4.25% Travasol Amino Acid Injection With Electrolytes In 5% Dextrose Quickmix Aminosyn II In Dextrose Injection Quick Mix 2.5% Travasol Aa With Electrolytes With 25% Dextrose Injec Travasol E 4.25% Travasol Amino Acid Without Electrolytes In 5% Dextrose Quickmix Aminosyn 8.5% Nutrineal Pd4 2.75%travasol Amino Acid InJ.W.eleC.W.5%dex. Hepatasol Aminosyn II with Electrolytes in Dextrose with Calcium Olimel 4.4% E Synthamin RenAmin 2.5%travasol Amino Acid InJ.W.eleC.W.25%dex FreAmine III NephrAmine Primene 10%-liq IV Premasol - sulfite-free (Amino Acid) Aminosyn II 8.5% M In 20% Dextrose (dual Chamber) 4.25% Amino Acid Injection Without Electrolytes In 20% Dextrose Quickmix Aminosyn 3.5% M 4.25% Travasol Amino Acid Injection With Electrolytes In 25% Dextrose Aminosyn II in Dextrose Aminosyn 7% Plenamine Aminosyn II with Electrolytes 2.5% Travasol Amino Acid Injection With Electrolytes In 10% Dextrose Aminosyn II 8.5% With 50% Dextrose Effervescent Potassium Chloride Olimel 4.4% Aminosyn-PF Clinimix 2.5% Travasol Aa Without Electrolytes In 10% Dextrose Injec Aminosyn 5% 5% Travasol Amino Acid Injection Without Electrolytes In 20% Dextrose Aminosyn RF Xyzmune 2.75% Travasol Amino Acid Injection With Electrolytes In 25% Dextrose Quickmix Aminosyn II and Dextrose 2.75% Travas. Amino Acid InJ.W.elecw.25%dex Travasol Amino Acid Inj 5.5% Clinimix Aminosyn 8.5% Injection With Electrolytes Primene 10% Vamin 18 Electrolyte-free Aminosyn HF Olimel 5.7% Smofkabiven 4.25% Travasol Amino Acid Injection With Electrolytes In 10% Dextrose Aminosyn Vamin N 4.25% Travasol Amino Acid Injection Without Electrolytes In 20% Dextrose 4.25% Travasol Amino Acid Injection With Electrolytes In 20% Dextrose Quickmix Nephramine Liq IV Aminosyn 10% W Electrolytes TrophAmine 2.5% Travasol Amino Acid Injection Without Electrolytes In 10% Dextrose Quickmix Renamin (amino Acids) Injection 4.25%trav. Amino Acid InJ.W.O.elect.5%dext. Aminosyn II 8.5% Injection Kabiven Aminosyn RF Injection Novamine Smofkabiven Peripheral Smofkabiven Electrolyte Free 8.5% Freamine III 20% Prosol Aminosyn-PF 7% Aminosyn II 5% Inj 4.25% Travasol Amino Acid Injection With Electrolytes In 20% Dextrose 5% Travasol Amino Acid Injection With Electrolytes In 20% Dextrose Aminosyn II FreAmine HBC ProSol Smofkabiven Extra Nitrogen Electrolyte Free 5% Travasol Amino Acid Injection Without Electrolytes In 25% Dextrose 4.25% Travasol Amino Acid Injection Without Electrlytes In 10% Dextrose Olimel 7.6% E HepatAmine Smofkabiven Extra Nitrogen Aminosyn-PF 10% Travasol Aminosyn II 7% Injection Perikabiven 4.25%travasol Amino Acid InJ.W.elecw.5%dex. Aminosyn II 7% With 10% Dextrose Aminosyn II 7% M In 10% Dextrose(dual Chamber) Periolimel 2.5% E Aminosyn II 7% With 50% Dextrose Aminosyn II 10% With Electrolytes Olimel 3.3% E Olimel 5.7% E Travasol Inj Without Electrolytes 5.5% Clinisol Aminosyn Sulfite Free 2.75% Travasol Amino Acid Injection With Electrolytes In 5% Dextrose Quickmix Primene Travasol Amino Acid Inj 8.5% Lysakare 4.25% Travasol Amino Acid Injection Without Electrolytes In 25% Dextrose
Indication	Supplemental lysine has putative anti-herpes simplex virus activity. There is preliminary research suggesting that it may have some anti-osteoporotic activity.
Categories	Amino Acids Amino Acids, Basic Amino Acids, Diamino Amino Acids, Essential Amino Acids, Peptides, and Proteins Blood and Blood Forming Organs Blood Substitutes and Perfusion Solutions Detoxifying Agents for Antineoplastic Treatment Dietary Supplements I.V. Solution Additives Lysine Proteinogenic Amino Acids Supplements
ATC-Code	V03AF11 B05XB03
CAS number	56-87-1

Drug Targets

Name	Target Sequence	Pharmacological Action	Actions
High affinity cationic amino acid transporter 1	MGCKVLLNIGQQMLRRKVVDCSREETRLSRCLNTFDLVALGVGSTLGAGV...	unknown
Cationic amino acid transporter 4	MARGLPTIASLARLCQKLNRLKPLEDSTMETSLRRCLSTLDLTLLGVGGM...	unknown
Cationic amino acid transporter 3	MPWQAFRRFGQKLVRRRTLESGMAETRLARCLSTLDLVALGVGSTLGAGV...	unknown
Low affinity cationic amino acid transporter 2	MIPCRAALTFARCLIRRKIVTLDSLEDTKLCRCLSTMDLIALGVGSTLGA...	unknown
Lysine--tRNA ligase	MAAVQAAEVKVDGSEPKLSKNELKRRLKAEKKVAEKEAKQKELSEKQLSQ...	unknown
Monocarboxylate transporter 10	MVLSQEEPDSARGTSEAQPLGPAPTGAAPPPGPGPSDSPEAAVEKVEVEL...	unknown	substrate,inhibitor
Solute carrier family 22 member 4	MRDYDEVIAFLGEWGPFQRLIFFLLSASIIPNGFNGMSVVFLAGTPEHRC...	unknown	inhibitor
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Drug Info/Drug Targets: DrugBank 3.0: a comprehensive resource for 'omics' research on drugs. Knox C, Law V, Jewison T, Liu P, Ly S, Frolkis A, Pon A, Banco K, Mak C, Neveu V, Djoumbou Y, Eisner R, Guo AC, Wishart DS. Nucleic Acids Res. 2011 Jan; 39 (Database issue):D1035-41. | PMID:21059682