MFX

1-cyclopropyl-6-fluoro-8-methoxy-7-[(4aS,7aS)-octahydro-6H-pyrrolo[3,4-b]pyridin-6-yl]-4-oxo-1,4-dihydroquinoline-3-carboxylic acid

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is present as a standalone ligand in 8 entries

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Chemical Component Summary
Name	1-cyclopropyl-6-fluoro-8-methoxy-7-[(4aS,7aS)-octahydro-6H-pyrrolo[3,4-b]pyridin-6-yl]-4-oxo-1,4-dihydroquinoline-3-carboxylic acid
Synonyms	moxifloxacin
Identifiers	7-[(4aS,7aS)-1,2,3,4,4a,5,7,7a-octahydropyrrolo[3,4-b]pyridin-6-yl]-1-cyclopropyl-6-fluoro-8-methoxy-4-oxo-quinoline-3-carboxylic acid
Formula	C₂₁ H₂₄ F N₃ O₄
Molecular Weight	401.431
Type	NON-POLYMER
Isomeric SMILES	COc1c2c(cc(c1N3C[C@@H]4CCCN[C@@H]4C3)F)C(=O)C(=CN2C5CC5)C(=O)O
InChI	InChI=1S/C21H24FN3O4/c1-29-20-17-13(19(26)14(21(27)28)9-25(17)12-4-5-12)7-15(22)18(20)24-8-11-3-2-6-23-16(11)10-24/h7,9,11-12,16,23H,2-6,8,10H2,1H3,(H,27,28)/t11-,16+/m0/s1
InChIKey	FABPRXSRWADJSP-MEDUHNTESA-N

Chemical Details
Formal Charge	0
Atom Count	53
Chiral Atom Count	2
Bond Count	57
Aromatic Bond Count	6

Drug Info: DrugBank

DrugBank ID	DB00218
Name	Moxifloxacin
Groups	investigational approved
Description	Moxifloxacin is a synthetic fluoroquinolone antibiotic agent. Bayer AG developed the drug (initially called BAY 12-8039) and it is marketed worldwide (as the hydrochloride) under the brand name Avelox (in some countries also Avalox) for oral treatment.
Synonyms	Moxifloxacino Moxifloxacin hydrochloride monohydrate Moxifloxacin hydrochloride 1-Cyclopropyl-6-fluoro-1,4-dihydro-8-methoxy-7-((4as,7as)-octahydro-6H-pyrrolo(3,4-b)pyridin-6-yl)-4-oxo-3-quinolinecarboxylic acid Moxifloxacin
Brand Names	Jamp-moxifloxacin Moxifloxacin ophthalmic solution Priva-moxifloxacin PMS-moxifloxacin Moxifloxacin Ophthalmic Solution Sandoz Moxifloxacin Vigamox Apo-moxifloxacin Dex-Moxi PF Ipg-moxifloxacin Dom-moxifloxacin Dex-Moxi Bio-moxifloxacin Moxeza Avelox Moxifloxacin Avelox ABC Pack M-moxifloxacin Triamcinolone-Moxifloxacin PF Auro-moxifloxacin Mylan-moxifloxacin Med-moxifloxacin DexMoxiKetor PF Mylan-moxifloxacin HCl Ophthalmic Solution Torrent-moxifloxacin PHL-moxifloxacin Moxifloxacin Ophthalmic Apo-moxifloxacin Hydrochloride Dex-Moxi-Ketor Moxifloxacin Hydrochloride Tablets, 400 mg Teva-moxifloxacin Riva-moxifloxacin Ag-moxifloxacin Jamp-moxifloxacin Tablets Avelox I.V. Moxifloxacin Injection Mar-moxifloxacin Ixoba M Moxifloxacin PF Moxifloxacin Hydrochloride Act Moxifloxacin
Indication	For the treatment of sinus and lung infections such as sinusitis, pneumonia, and secondary infections in chronic bronchitis. Also for the treatment of bacterial conjunctivitis (pinkeye).
Categories	Anti-Bacterial Agents Anti-Infective Agents Antibacterials for Systemic Use Antiinfectives for Systemic Use Cytochrome P-450 CYP1A2 Inhibitors Cytochrome P-450 CYP1A2 Inhibitors (moderate) Cytochrome P-450 Enzyme Inhibitors Enzyme Inhibitors Fluoroquinolone Antibacterial Fluoroquinolones Heterocyclic Compounds, Fused-Ring Moderate Risk QTc-Prolonging Agents Ophthalmologicals QTc Prolonging Agents Quinolines Quinolone Antimicrobial Quinolones Sensory Organs Topoisomerase II Inhibitors Topoisomerase Inhibitors
ATC-Code	S01AE07 J01MA14
CAS number	151096-09-2

Drug Targets

Name	Target Sequence	Pharmacological Action	Actions
DNA gyrase subunit A	MTDSIQSSITPVNIEEELKSSYLDYAMSVIVGRALPDVRDGLKPVHRRVL...	unknown	inhibitor
DNA topoisomerase 4 subunit A	MTNINYEGIEQMPLRTFTEKAYLNYSMYVIMDRALPFIGDGLKPVQRRIV...	unknown	inhibitor
DNA topoisomerase 2-alpha	MEVSPLQPVNENMQVNKIKKNEDAKKRLSVERIYQKKTQLEHILLRPDTY...	unknown	inhibitor
Serum paraoxonase/arylesterase 1	MAKLIALTLLGMGLALFRNHQSSYQTRLNALREVQPVELPNCNLVKGIET...	unknown	inhibitor
Cytochrome P450 1A2	MALSQSVPFSATELLLASAIFCLVFWVLKGLRPRVPKGLKSPPEPWGWPL...	unknown	inhibitor

Drug Info/Drug Targets: DrugBank 3.0: a comprehensive resource for 'omics' research on drugs. Knox C, Law V, Jewison T, Liu P, Ly S, Frolkis A, Pon A, Banco K, Mak C, Neveu V, Djoumbou Y, Eisner R, Guo AC, Wishart DS. Nucleic Acids Res. 2011 Jan; 39 (Database issue):D1035-41. | PMID:21059682