MXD

6-PIPERIDIN-1-YLPYRIMIDINE-2,4-DIAMINE 3-OXIDE

Find entries where: MXD

is present as a standalone ligand in 2 entries

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Chemical Component Summary
Name	6-PIPERIDIN-1-YLPYRIMIDINE-2,4-DIAMINE 3-OXIDE
Synonyms	MINOXIDIL
Identifiers	3-oxido-6-piperidin-1-yl-pyrimidin-3-ium-2,4-diamine
Formula	C₉ H₁₅ N₅ O
Molecular Weight	209.248
Type	NON-POLYMER
Isomeric SMILES	c1c([n+](c(nc1N2CCCCC2)N)[O-])N
InChI	InChI=1S/C9H15N5O/c10-7-6-8(12-9(11)14(7)15)13-4-2-1-3-5-13/h6H,1-5,10H2,(H2,11,12)
InChIKey	ZFMITUMMTDLWHR-UHFFFAOYSA-N

Chemical Details
Formal Charge	0
Atom Count	30
Chiral Atom Count	0
Bond Count	31
Aromatic Bond Count	6

Drug Info: DrugBank

DrugBank ID	DB00350
Name	Minoxidil
Groups	investigational approved
Description	A potent direct-acting peripheral vasodilator (vasodilator agents) that reduces peripheral resistance and produces a fall in blood pressure.
Synonyms	Minoxidilum Minoxidil sulfate Minoxidil 2,4-Diamino-6-piperidinopyrimidine 3-oxide 6-Piperidin-1-ylpyrimidine-2,4-diamine 3-oxide Minossidile
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Simply Right Minoxidil Up and Up Hair Regrowth Treatment for Men Minoxidil 5% / Progesterone 0.1% / Tretinoin 0.025% Grow Girl Minoxidil 7% / Tretinoin 0.025% Hims Shapiro MD 5% Minoxidil Hair Regrowth Treatment for Men Qilib Hair Regrowth Treatment for Women Mens rogaine Unscented Formula Minoxidil for Men Nexxus Hair Regrowth Treatment Re-Gro Equaline hair regrowth treatment for men Betamethasone Dipropionate 0.05% / Minoxidil 5% / Niacinamide 2% / Pentoxifylline 0.5% GIOTTO Minoxidil Hair Growth Spray. 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VITADIL-5A Hair Regrowth Treatment Mens SPECTRAL UHP EXTRA STRENGTH HAIR REGROWTH TREATMENT Minoxidil (For Men) Vitadil-5A 5% Minoxidil Topical serum EXDEPLOY 5% Minoxidil Topical Gel Baoveri Hair growth serum Kirkland Signature Minoxidil bourn Hair Regrowth Treatment for Men kirkland signature Minoxidil Hims Hair Regrowth Treatment Good Neighbor Pharmacy Hair Regrowth Treatment for Men Good Sense Hair Regrowth Treatment for Women Minox Daylogic For Men Elevate 2% Minoxidil Hair Liquid Equaline Hair Regrowth Treatment For Women Loniten 10mg MDhair Extra Strength hair regrowth treatment for Men Elevate 5% Minoxidil Hair Liquid Elevate 2% Minoxidil Liquid Hair Regrowth Treatment Extra Strength for Men HERYTEE BIOTIN Minoxidi 5% Topical Serum Kerastase Densifique Members Mark Hair Regrowth Treatment Polaris Research NR-02 Hair Regrowth Minoxidil For Women Men's Rogaine Ruigoo Minoxidil Topical Gel VIOFAIRY 5% Minoxidil Hair Growth serum Cerafill Retaliate Extra Strength For Men Image Essentials Hair Regrowth Treatment For Men Equaline Hair Regrowth Treatment for Women Signature Care Hair Regrowth Treatment for men Hair regrowth treatment for men Minoxidil Foam Women's Rogaine Foam 5% Signature Care Hair Regrowth Treatment Mens Minoxidil Hair Regrowth Good Sense hair regrowth treatment for women INTELLIGENT Mens Minoxidil Extra Strength 5 Minoxidil Mens Intelligent Hair Regrowth Treatment Hair Regrowth Formula Myhair Hair Regrowth Treatment Rootly Extra Strength Hair Regrowth Treatment for Men Vanarex Hair Regrowth Treatment Shea Moisture Hair Regrowth Treatment for Women Up and Up minoxidil Elevate Beard Growth Serum Minoxidil (for Women) Gromedi 5x Up and Up Minoxidil Hair Labs Mens Extra Strength 5 Minoxidil Bakumokon 7% Minoxidil Sulfate Elevate 2% Minoxidil Foam EXT Hair Regrowth Treatment for Men 2% Minoxidil Regular Strength for Men Minoxidil Solution Mens rogaine Minoxidil - Unscented Formula SUNHEAL 5% Minoxidil Hair Growth Kit THICK HEAD Extra Strength for Men 5 Minoxidil Topical GETTIK Hair Regrowth Treatment Womens Minoxidil Hair Regrowth Azelomax Forte Basic Care Hair Regrowth Yoocoi Minoxidil HAIR REGROWTH SERUM Elevate Minoxidil Foam Finasteride 0.1% / Minoxidil 5% GROFULLY Mens Extra Strength Hair Regrowth Treatment Finasteride 0.1% / Minoxidil 7% GROFULLY Womens Hair Regrowth Treatment Loniten 2.5mg Jardient 5% Minoxidil Hair Growth Serum Regenivade Hair Growth Foam SUAI 5% MinoxidiL Hair Growth Solution Toppik Womens Hair Regrowth Treatment Lilivera 5% Minoxidil Hair Serum LE PHOQUA Hair Regrowth Serum BIOTIN 5% MINOXIDIL Harmon Face Values Minoxidil Mens Hers Minoxidil Womens Minoxidil Hair Growth System Loesch Hair Regrowth Formula Unscented Topical Solution Regular-Strength for Men and Women Equate Hair Regrowth Treatment 5% Minoxidil Hair growth Serum Dexamethasone Sodium Phosphate 0.1% / Finasteride 0.1% / Minoxidil 5% FOLLIXIL Hair and Beard Growth-Foam Hair Regrowth Treatment for Men Extra Strength Finasteride 0.1% / Minoxidil 7% / Tretinoin 0.025% Bosley MD Extra Strength for Men Minoxigaine Topical Solution - 2% 5% Minoxidil Hair Regrowth Treatment 5% Minoxidil Serum Finally Hair Minoxidil 5% Hair Growth Foam HERYTEE 5% minoxidil hair care essential oil Mens ComBack HAIR REGROWTH TREATMENT EXTRA STRENGTH UNSCENTED Womens Rogaine - Unscented Harmon Face Values Minoxidil Chrmplx Hair Regrowth Treatment Salubrito Hair Growth Treatment GIOTTO Minoxidil Hair Growth Serum Mens Rogaine Extra Strength KERANIQUE For Women Hair Regrowth Treatment Solution BUNEE Hair Growth Serum Gainextra Hair Regrowth Treatment for Men 5% ASDTOTIO 5% minoxidil
Indication	For the treatment of severe hypertension and in the topical treatment (regrowth) of androgenic alopecia in males and females and stabilisation of hair loss in patients with androgenic alopecia.
Categories	Antihypertensive Agents Antihypertensive Agents Indicated for Hypertension Arteriolar Smooth Muscle, Agents Acting On Arteriolar Vasodilation Arteriolar Vasodilator Cardiovascular Agents Dermatologicals Direct Vasodilators Hypotensive Agents Misc. Skin and Mucous Membrane Agents Piperidines Potassium Channel Opener Pyrimidine Derivatives Pyrimidines UGT1A1 Substrates Vasodilating Agents
ATC-Code	D11AX01 C02DC01
CAS number	38304-91-5

Drug Targets

Name	Target Sequence	Pharmacological Action	Actions
ATP-sensitive inward rectifier potassium channel 1	MNASSRNVFDTLIRVLTESMFKHLRKWVVTRFFGHSRQRARLVSKDGRCN...	unknown	inducer
Renin	MDGWRRMPRWGLLLLLWGSCTFGLPTDTTTFKRIFLKRMPSIRESLKERG...	unknown
Prostaglandin G/H synthase 1	MSRSLLLWFLLFLLLLPPLPVLLADPGAPTPVNPCCYYPCQHQGICVRFG...	unknown	inducer
UDP-glucuronosyltransferase 1-1	MAVESQGGRPLVLGLLLCVLGPVVSHAGKILLIPVDGSHWLSMLGAIQQL...	unknown	substrate

Drug Info/Drug Targets: DrugBank 3.0: a comprehensive resource for 'omics' research on drugs. Knox C, Law V, Jewison T, Liu P, Ly S, Frolkis A, Pon A, Banco K, Mak C, Neveu V, Djoumbou Y, Eisner R, Guo AC, Wishart DS. Nucleic Acids Res. 2011 Jan; 39 (Database issue):D1035-41. | PMID:21059682