Norethisterone, also known as norethindrone, is a synthetic progestational hormone belonging to the 19-nortestosterone-derived class of progestins.[A10367] It is further classified as a second-generation progestin, along with [levonorgestrel] and its derivatives, and is the active form of several other progestins including [norethynodrel] and [lynestrenol].[A10367] Norethisterone mimics the actions of endogenous [progesterone], albeit with a greater potency,[A188075] and is used on its own or in combination with estrogen derivatives in a variety of applications including contraception and hormone replacement therapy.[L9527,L10301,L10304,L10307] First derived in 1951 in Mexico City, norethisterone was originally intended for use as a remedy for irregular menstruation and endometriosis, and was not marketed for use as an oral contraceptive until 1962.[L10439]
Norethindrone and Ethinyl Estradiol, and Ferrous Fumarate
Synphasic 28 Tablets
Ortho 7/7/7 Tablets (28 Day)
Norethindrone Acetate and Ethinyl Estradiol, and Ferrous Fumarate
LOESTRIN Fe 1/20
Gildagia
Femlyv
Briellyn
Nortrel 21 Day
Ortho 1/35 Tablets (28 Day)
Ortho-novum 10/11
Lyza
Hailey 24 Fe
Microgestin Fe 1/20
Generess
Norinyl 1/50 -(21-day Regimen)
LOESTRIN Fe 1.5/30
Merzee
Junel Fe 1.5/30
Etyqa
Larin 24 Fe
Select 1/35 (28-day)
Tilia Fe
Select 1/35 (21-day)
Blisovi Fe 1.5/30
Minastrin 24 Fe
Taysofy
AUROVELA Fe
LOESTRIN Fe 1.5/30 28 Day
Norethindrone and ethinyl estradiol and ferrous fumarate
Tarina Fe 1/20 EQ
Norethindrone
Jencycla
Zeosa
Microgestin 24 Fe
Pirmella 1/35
Brevicon 0.5/35 Tablets (21-day Pack)
Blisovi Fe 1/20
Brevicon 1/35 28 Tab
Nortrel (21 Day Regimen)
Nortrel 28 Day
Aurovela 1.5/30
LOESTRIN Fe 1/20 28 Day
Brevicon 1/35 Tablets (21-day Pack)
Layolis Fe
Norethindrone Acetate and Ethinyl Estradiol and Ferrous Fumarate
WYMZYA Fe
Pirmella 7/7/7
Norethindrone Acetate
Loestrin 21 1/20
Oshih
Ortho 0.5/35 Tablets (28 Day)
Microgestin
Nylia 1/35
Loestrin 21 1.5/30
Hailey 1.5/30
Norlyda
Synphasic 21 Tablets
Gemmily
Ovcon 50
Nexesta Fe
Ortho-Novum 777
Oriahnn
MICROGESTIN Fe 1/20
Alyacen 1/35
Necon 1/35 (28 Day Regimen)
Taytulla
Activella
Larin Fe 1/20
Lo Loestrin Fe
Deblitane
Norethindrone acetate
Aurovela 24 Fe
Estalis 140/50 Mcg
Necon 1/35
Norlutate
Cyclafem 1/35
Norethindrone and ethinyl estradiol
Zenchent FE
Norinyl 1/50 28 Tab
Junel Fe 1/20
Necon 777 777
Aurovela 1/20
Cyonanz
Microgestin Fe
Lyleq
Ovcon 35
Blisovi 24 Fe
Wera
Camila
Loestrin 1.5/30
Lupaneta Pack
Larin 1.5/30
Sharobel
Synphasic-28 Tablets
Necon 0.5/35
Incassia
Indication
Norethisterone is indicated as an oral contraceptive when given as monotherapy[L9527] or in combination with an estrogen component, such as [ethinylestradiol] or [estradiol].[L10313,L10307] In combination with an estrogen component, oral norethisterone is also indicated as a hormone replacement therapy in the treatment of postmenopausal osteoporosis and moderate-to-severe vasomotor symptoms arising from menopause.[L10304] When applied via transdermal patch, the combination of norethisterone and estradiol is indicated for the treatment of hypoestrogenism, vulvovaginal atrophy, and moderate-severe vasomotor symptoms.[L10301] Norethisterone, taken in combination with intramuscular [leuprolide], is also indicated for the symptomatic treatment of endometriosis-related pain.[L10310]
Categories
Adrenal Cortex Hormones
Anti-Gonadotropin-Releasing Hormones
Combination Contraceptives (with Estrogen and derivatives)
Drug Info/Drug Targets: DrugBank 3.0: a comprehensive resource for 'omics' research on drugs. Knox C, Law V, Jewison
T, Liu P, Ly S, Frolkis A, Pon A, Banco K, Mak C, Neveu V, Djoumbou Y, Eisner R, Guo AC, Wishart DS.
Nucleic Acids Res. 2011 Jan; 39 (Database issue):D1035-41. | PMID:21059682
