NET
TETRAETHYLAMMONIUM ION
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is present as a standalone ligand in 11 entries
Chemical Component Summary | |
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Name | TETRAETHYLAMMONIUM ION |
Identifiers | tetraethylazanium |
Formula | C8 H20 N |
Molecular Weight | 130.251 |
Type | NON-POLYMER |
Isomeric SMILES | CC[N+](CC)(CC)CC |
InChI | InChI=1S/C8H20N/c1-5-9(6-2,7-3)8-4/h5-8H2,1-4H3/q+1 |
InChIKey | CBXCPBUEXACCNR-UHFFFAOYSA-N |
Chemical Details | |
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Formal Charge | 1 |
Atom Count | 29 |
Chiral Atom Count | 0 |
Bond Count | 28 |
Aromatic Bond Count | 0 |
Drug Info: DrugBank
DrugBank ID | DB08837 |
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Name | Tetraethylammonium |
Groups |
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Description | Tetraethylammonium is an experimental drug with no approved indication or marketed formulation. The only marketed drug containing tetraethylammonium was a combination drug called Fosglutamina B6, but this drug has now been discontinued. As an experimental agent, tetraethylammonium is used in its salt forms such as tetraethylammonium chloride and tetraethylammonium bromide. Its mechanism of action is still being investigated, but it is known that tetraethylammonium blocks autonomic ganglia, calcium- and voltage- activated potassium channels, and nicotinic acetylcholine receptors. Because of its inhibitory actions at the autonomic ganglia, tetraethylammonium was thought to be a potential therapeutic vasodilator but serious toxic effects were found. The most common use of tetraethylammonium presently is as a pharmacological research agent that blocks selective potassium channels. Structurally, tetraethylammonium is positively charged due to its central quaternary ammonium. |
Synonyms |
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Indication | Tetraethylammonium is an experimental drug with no approved indication. |
Categories |
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CAS number | 66-40-0 |
Drug Targets
Name | Target Sequence | Pharmacological Action | Actions |
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pH-gated potassium channel KcsA | MPPMLSGLLARLVKLLLGRHGSALHWRAAGAATVLLVIVLLAGSYLAVLA... | unknown | inhibitor |
Neuronal acetylcholine receptor subunit alpha-9 | MNWSHSCISFCWIYFAASRLRAAETADGKYAQKLFNDLFEDYSNALRPVE... | unknown | agonist,inhibitor |
Calcium-activated potassium channel subunit alpha-1 | MANGGGGGGGSSGGGGGGGGGSGLRMSSNIHANNLSLDASSSSSSSSSSS... | unknown | inhibitor |
Potassium voltage-gated channel subfamily A member 1 | MTVMSGENVDEASAAPGHPQDGSYPRQADHDDHECCERVVINISGLRFET... | unknown | blocker |
Solute carrier family 22 member 1 | MPTVDDILEQVGESGWFQKQAFLILCLLSAAFAPICVGIVFLGFTPDHHC... | unknown | |
View More |
Drug Info/Drug Targets: DrugBank 3.0: a comprehensive resource for 'omics' research on drugs. Knox C, Law V, Jewison
T, Liu P, Ly S, Frolkis A, Pon A, Banco K, Mak C, Neveu V, Djoumbou Y, Eisner R, Guo AC, Wishart DS.
Nucleic Acids Res. 2011 Jan; 39 (Database issue):D1035-41. | PMID:21059682
Related Resource References
Resource Name | Reference |
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PubChem | 5413 |
ChEMBL | CHEMBL9324 |
ChEBI | CHEBI:44296 |
COD | 2006032, 4114166, 2222417, 4516323, 4114165, 4340163, 2011234, 2231239, 4126229, 2011097, 7113680, 7104863, 8101491 |