O6P

Doripenem

Find entries where: O6P

is present as a standalone ligand in 1 entries

Find related ligands:

Chemical Component Summary
Name	Doripenem
Synonyms	(4R,5S,6S)-6-[(1R)-1-hydroxyethyl]-4-methyl-7-oxo-3-({(3S,5S)-5-[(sulfamoylamino)methyl]pyrrolidin-3-yl}sulfanyl)-1-azabicyclo[3.2.0]hept-2-ene-2-carboxylic acid
Identifiers	(4~{R},5~{S},6~{S})-4-methyl-6-[(1~{R})-1-oxidanylethyl]-7-oxidanylidene-3-[(3~{S},5~{S})-5-[(sulfamoylamino)methyl]pyrrolidin-3-yl]sulfanyl-1-azabicyclo[3.2.0]hept-2-ene-2-carboxylic acid
Formula	C₁₅ H₂₄ N₄ O₆ S₂
Molecular Weight	420.504
Type	NON-POLYMER
Isomeric SMILES	C[C@@H]1[C@@H]2[C@H](C(=O)N2C(=C1S[C@H]3C[C@H](NC3)CNS(=O)(=O)N)C(=O)O)[C@@H](C)O
InChI	InChI=1S/C15H24N4O6S2/c1-6-11-10(7(2)20)14(21)19(11)12(15(22)23)13(6)26-9-3-8(17-5-9)4-18-27(16,24)25/h6-11,17-18,20H,3-5H2,1-2H3,(H,22,23)(H2,16,24,25)/t6-,7-,8+,9+,10-,11-/m1/s1
InChIKey	AVAACINZEOAHHE-VFZPANTDSA-N

Chemical Details
Formal Charge	0
Atom Count	51
Chiral Atom Count	6
Bond Count	53
Aromatic Bond Count	0

Drug Info: DrugBank

DrugBank ID	DB06211
Name	Doripenem
Groups	investigational approved
Description	Doripenem is a broad-spectrum, carbapenem antibiotic marketed under the brand name Doribax by Janssen. Doripenem injection was approved by the FDA in 2007 to treat complicated urinary tract and intra-abdominal infections. In a clinical trial of doripenem treatment in ventilator associated pneumonia (vs. imipenem and cilastatin), it was found that doripenem carried an increased risk of death and lower clinical cure rates, resulting in a premature termination of the trial. The FDA revised the doripenem label in 2014 to include a warning against use in ventilator-associated pneumonia and to reiterate its safety and efficacy for its approved indications.
Synonyms	Doripenem hydrate Doripenem
Brand Names	Doripenem Doribax
Indication	Doripenem is indicated in the treatment of complicated intra-abdominal infections and complicated urinary tract infections, including pyelonephritis, caused by designated susceptible bacteria.
Categories	Amides Anti-Bacterial Agents Anti-Infective Agents Antibacterials for Systemic Use Antiinfectives for Systemic Use beta-Lactams Carbapenems Drugs that are Mainly Renally Excreted Heterocyclic Compounds, Fused-Ring Lactams OAT3/SLC22A8 Substrates Penem Antibacterial Sulfur Compounds
ATC-Code	J01DH04
CAS number	148016-81-3

Drug Targets

Name	Target Sequence	Pharmacological Action	Actions
Penicillin-binding protein 1A	MKFVKYFLILAVCCILLGAGSIYGLYRYIEPQLPDVATLKDVRLQIPMQI...	unknown	antagonist,inhibitor
Penicillin-binding protein 1B	MAGNDREPIGRKGKPTRPVKQKVSRRRYEDDDDYDDYDDYEDEEPMPRKG...	unknown	antagonist,inhibitor
Penicillin-binding protein 2	MKLQNSFRDYTAESALFVRRALVAFLGILLLTGVLIANLYNLQIVRFTDY...	unknown	antagonist,inhibitor
Penicillin-binding protein 3	MKLNYFQGALYPWRFCVIVGLLLAMVGAIVWRIVDLHVIDHDFLKGQGDA...	unknown	antagonist,inhibitor
Penicillin-binding protein 4	MKNLISIIIILCLTLSIMTPYAQATNSDVTPVQAANQYGYAGLSAAYEPT...	unknown	antagonist,inhibitor
Dipeptidase 1	MWSGWWLWPLVAVCTADFFRDEAERIMRDSPVIDGHNDLPWQLLDMFNNR...	unknown	substrate
Solute carrier family 22 member 8	MTFSEILDRVGSMGHFQFLHVAILGLPILNMANHNLLQIFTAATPVHHCR...	unknown	substrate
View More

Drug Info/Drug Targets: DrugBank 3.0: a comprehensive resource for 'omics' research on drugs. Knox C, Law V, Jewison T, Liu P, Ly S, Frolkis A, Pon A, Banco K, Mak C, Neveu V, Djoumbou Y, Eisner R, Guo AC, Wishart DS. Nucleic Acids Res. 2011 Jan; 39 (Database issue):D1035-41. | PMID:21059682