PNT

1,5-BIS(4-AMIDINOPHENOXY)PENTANE

Find entries where: PNT

is present as a standalone ligand in 10 entries

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Chemical Component Summary
Name	1,5-BIS(4-AMIDINOPHENOXY)PENTANE
Identifiers	4-[5-(4-carbamimidoylphenoxy)pentoxy]benzenecarboximidamide
Formula	C₁₉ H₂₄ N₄ O₂
Molecular Weight	340.419
Type	NON-POLYMER
Isomeric SMILES	c1cc(ccc1C(=N)N)OCCCCCOc2ccc(cc2)C(=N)N
InChI	InChI=1S/C19H24N4O2/c20-18(21)14-4-8-16(9-5-14)24-12-2-1-3-13-25-17-10-6-15(7-11-17)19(22)23/h4-11H,1-3,12-13H2,(H3,20,21)(H3,22,23)
InChIKey	XDRYMKDFEDOLFX-UHFFFAOYSA-N

Chemical Details
Formal Charge	0
Atom Count	49
Chiral Atom Count	0
Bond Count	50
Aromatic Bond Count	12

Drug Info: DrugBank

DrugBank ID	DB00738
Name	Pentamidine
Groups	approved investigational
Description	Antiprotozoal agent effective in trypanosomiasis, leishmaniasis, and some fungal infections; used in treatment of pneumocystis pneumonia in HIV-infected patients. It may cause diabetes mellitus, central nervous system damage, and other toxic effects.
Synonyms	Pentamidin p,p'-(pentamethylenedioxy)dibenzamidine 4,4'-(pentamethylenedioxy)dibenzamidine 1,5-bis(4-amidinophenoxy)pentane Pentamidine mesylate Pentamidine gluconate Pentamidine isethionate Pentamidinum Pentamidina Pentamidine 4,4'-Diamidinodiphenoxypentane 4,4'-(1,5-pentanediylbis(oxy))bis-benzenecarboximidamide
Brand Names	NebuPent Pentam 300 Pentacarinat 300 Inj Pws 300mg/vial Pentamidine Isetionate for Injection BP Pentamidine Isethionate Inj 300mg/vial BP Pentamidine Isethionate
Indication	For the treatment of pneumonia due to <i>Pneumocystis carinii</i>.
Categories	Agents Against Leishmaniasis and Trypanosomiasis Agents causing hyperkalemia Amidines Anti-Infective Agents Antibiotics for Pneumocystis Pneumonia Antifungal Agents Antiparasitic Agents Antiparasitic Products, Insecticides and Repellents Antiprotozoals Benzamidines Blood Glucose Lowering Agents Cytochrome P-450 CYP2C19 Substrates Cytochrome P-450 CYP2D6 Substrates Cytochrome P-450 CYP3A Substrates Cytochrome P-450 CYP3A5 Substrates Cytochrome P-450 Substrates Hyperglycemia-Associated Agents Hypoglycemia-Associated Agents Miscellaneous Antiprotozoals Moderate Risk QTc-Prolonging Agents Nephrotoxic agents QTc Prolonging Agents Trypanocidal Agents
ATC-Code	P01CX01
CAS number	100-33-4

Drug Targets

Name	Target Sequence	Pharmacological Action	Actions
tRNA (cytosine(38)-C(5))-methyltransferase	MEPLRVLELYSGVGGMHHALRESCIPAQVVAAIDVNTVANEVYKYNFPHT...	unknown	other
DNA	-	unknown	intercalation
Cytochrome P450 2C19	MDPFVVLVLCLSCLLLLSIWRQSSGRGKLPPGPTPLPVIGNILQIDIKDV...	unknown	substrate
Cytochrome P450 1A1	MLFPISMSATEFLLASVIFCLVFWVIRASRPQVPKGLKNPPGPWGWPLIG...	unknown	substrate
Cytochrome P450 2D6	MGLEALVPLAVIVAIFLLLVDLMHRRQRWAARYPPGPLPLPGLGNLLHVD...	unknown	substrate
Cytochrome P450 3A5	MDLIPNLAVETWLLLAVSLVLLYLYGTRTHGLFKRLGIPGPTPLPLLGNV...	unknown	substrate
Cytochrome P450 4A11	MSVSVLSPSRLLGDVSGILQAASLLILLLLLIKAVQLYLHRQWLLKALQQ...	unknown	substrate
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Drug Info/Drug Targets: DrugBank 3.0: a comprehensive resource for 'omics' research on drugs. Knox C, Law V, Jewison T, Liu P, Ly S, Frolkis A, Pon A, Banco K, Mak C, Neveu V, Djoumbou Y, Eisner R, Guo AC, Wishart DS. Nucleic Acids Res. 2011 Jan; 39 (Database issue):D1035-41. | PMID:21059682