Chemical Component Summary

NamePHOSPHONOFORMIC ACID
Identifiersphosphonomethanoic acid
FormulaC H3 O5 P
Molecular Weight126.005
TypeNON-POLYMER
Isomeric SMILESC(=O)(O)P(=O)(O)O
InChIInChI=1S/CH3O5P/c2-1(3)7(4,5)6/h(H,2,3)(H2,4,5,6)
InChIKeyZJAOAACCNHFJAH-UHFFFAOYSA-N

Chemical Details

Formal Charge0
Atom Count10
Chiral Atom Count0
Bond Count9
Aromatic Bond Count0

Drug Info: DrugBank

DrugBank IDDB00529 
NameFoscarnet
Groups approved
DescriptionAn antiviral agent used in the treatment of cytomegalovirus retinitis. Foscarnet also shows activity against human herpes viruses and HIV.
Synonyms
  • Phosphonomethanoic acid
  • Phosphonoformate
  • Foscarnet sodium
  • Carboxyphosphonic acid
  • Foscarnet
Brand Names
  • Foscavir
  • Foscavir UK
  • Foscarnet Sodium
  • Vocarvi
  • Foscarnet
IndicationFor the treatment of CMV retinitis in patients with acquired immunodeficiency syndrome (AIDS) and for treatment of acyclovir-resistant mucocutaneous HSV infections in immunocompromised patients.
Categories
  • Acetates
  • Acids, Acyclic
  • Anti-Infective Agents
  • Anti-Retroviral Agents
  • Antiinfectives for Systemic Use
ATC-CodeJ05AD01
CAS number4428-95-9

Drug Targets

NameTarget SequencePharmacological ActionActions
DNA polymerase catalytic subunitMFSGGGGPLSPGGKSAARAASGFFAPAGPRGASRGPPPCLRQNFYNPYLA...unknowninhibitor
DNA polymerase catalytic subunitMFFNPYLSGGVTGGAVAGGRRQRSQPGSAQGSGKRPPQKQFLQIVPRGVM...unknowninhibitor
Solute carrier family 22 member 6MAFNDLLQQVGGVGRFQQIQVTLVVLPLLLMASHNTLQNFTAAIPTHHCR...unknowninhibitor
Monocarboxylate transporter 1MPPAVGGPVGYTPPDGGWGWAVVIGAFISIGFSYAFPKSITVFFKEIEGI...unknownsubstrate
Drug Info/Drug Targets: DrugBank 3.0: a comprehensive resource for 'omics' research on drugs. Knox C, Law V, Jewison T, Liu P, Ly S, Frolkis A, Pon A, Banco K, Mak C, Neveu V, Djoumbou Y, Eisner R, Guo AC, Wishart DS. Nucleic Acids Res. 2011 Jan; 39 (Database issue):D1035-41. | PMID:21059682

Related Resource References

Resource NameReference
PubChem 3415
ChEMBL CHEMBL666
ChEBI CHEBI:127780