PX9

Pramocaine

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is present as a standalone ligand in 6 entries

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Chemical Component Summary
Name	Pramocaine
Identifiers	4-[3-(4-butoxyphenoxy)propyl]morpholine
Formula	C₁₇ H₂₇ N O₃
Molecular Weight	293.401
Type	NON-POLYMER
Isomeric SMILES	CCCCOc1ccc(cc1)OCCCN2CCOCC2
InChI	InChI=1S/C17H27NO3/c1-2-3-12-20-16-5-7-17(8-6-16)21-13-4-9-18-10-14-19-15-11-18/h5-8H,2-4,9-15H2,1H3
InChIKey	DQKXQSGTHWVTAD-UHFFFAOYSA-N

Chemical Details
Formal Charge	0
Atom Count	48
Chiral Atom Count	0
Bond Count	49
Aromatic Bond Count	6

Drug Info: DrugBank

DrugBank ID	DB09345
Name	Pramocaine
Groups	approved
Description	Pramocaine (also known as pramoxine or pramoxine HCI) is a topical anesthetic and antipruritic. It is used for many dermatological and anorectal/anogenital conditions including minor cuts/burns, insect bites, hives/rashes due to poison ivy exposure, hemorrhoids and other anorectal/anogenital disorders. Pramocaine is available by itself and in combination with other medications in various topical preparations. It works by preventing ionic fluctuations needed for neuron membrane depolarization and action potential propagation.
Synonyms	Pramocaína Pramoxine Pramoxine hydrochloride Pramocaine
Brand Names	Leader Calamine Plus Luvena Feminine Wipes Meijer Triple Antibiotic Plus Select Brand Hemorrhoid Pramoxine-HC Gold Bond Anti Itch Fleet Anti-Itch Soothing Wipes 1 Pramoxine Hydrochloride HEB Maximum Strength Pain Relief Hemorrhoidal Itch Relief Moisturizing Lotion Avedana Hemorrhoidal Maximum Strength Neosporin Plus Pain Relief Neo To Go First Aid Antiseptic Pain Relieving Dr Bells Pomade MEDICATED ANTI-ITCH Well at Walgreens Anugesic-HC Suppositories Triple Antibiotic with Pain Relief Maximum Strength CareALL Triple Antibiotic plus Pain Relief Epifoam Rexall Maximum Strength Hemorrhoidal No More Bumps Equaline First Aid Antibiotic Multi Action Sandoz Anuzinc HC Plus Sunmark Caldyphen Clear LEADER Caldyphen Rite Aid Pharmacy Antibiotic With Pain Relief Dermoplast Poison Ivy Treatment Triple Antibiotic with Pain Relief Best Choice Anti-Itch Clear Publix Calamine Medicated Good Neighbor Pharmacy Antibiotic and Pain Relief Natureplex Hemorrhoidal Western Family Antibiotic Plus Pain Relief L-Topical CALAMINE 8% PRAMOXINE HCL 1% CVS Health Hemorrhoidal Cream Smart Sense triple antibitotic plus pain relief Humco Calagesic Equate Hemorrhoidal Leader Family Wellness Antiseptic and Pain Relief Gold Bond Intensive Relief Anti-Itch Tripleantibioticapainscaritch LOLA Vaginal Itch Relief Wipes First Aid Antibiotic Procort Pramosone E Cream 2.5% hydrocortisone acetate 2.5% pramoxine hydrochloride 1% First Aid Sensitive Anti-Itch Sarna P Mineral Oil, Pramoxine Hydrochloride and Zinc Oxide Blistex Ivarest Poison Ivy Itch Clear Anti-itch Lotion Harris Teetter Calagesic Antibiotic Plus Pain Relief Equaline Hemorrhoidal Walgreens Kids Multi-Antibiotic with Pain Relief Cream Nikzon Hemorrhoidal DDM Calagesic Itch-X Clear Anti Itch Hydrocortisone Acetate Pramoxine Hcl Freds Medicated anti itch Triple Antibiotic plus Pain Relief Maximum Strength proctofoam HC GoodSense Antibiotic plus Pain Relief Shopko Triple Antibiotic Plus Pramox HC Lotion Western Family Triple Antibiotic plus Pain Relief Scalpicin Medicated Wipes Hydrocortisone Acetate Pramoxine Hydrochloride Aveeno Calm Plus Restore Itch Relief Balm Hemorrhoidal Cream with Aloe Safeway Antibiotic Plus Pain Relief Aveeno Calamine and Pramoxine Hydrochloride Anti Itch Clear Anti-Itch Proctodan-HC Suppositories Leader Triple antibiotic and pain relief Skin Relief Medicated Anti-itch Treatment Antibiotic Plus Pain Relief Maximum Strength Cocoskin Caldyphen Clear Eczemin DDM Calaclear First Degree Maximum Strength Burn Publix Clear Anti-Itch Oticin Rugby Caldyphen Clear TopCare Calagesic Neosporin Pain Itch Scar Ivy Wash Anti-Itch Family Wellness Plus Pain Relief CeraVe Itch Relief Moisturizing Cream Anodan-plus Ointment Anti Itch Soothing 1 Pramoxine Hydrochloride Quality Choice Triple Antibiotic Plus Pain Reliever Proctodan-HC Ointment Hemorrhoid Ointment Preparation H Totables Pain Relief Neosporin Plus Pain Relief First Aid Antibiotic Pain Relieving For Kids Multi Antibiotic with Pain Relief Maximum Strength Childrens Double Antibiotic with Pain Relief First Aid Antibiotic Plus Pain Relief Maximum Strength CVS Fragrance Free Anti-Itch Antibiotic, Pain and Scar Bacitraycin MAX Pain Relief Polysporin Lip Treatment First Aid Triple Antibiotic Pain and Scar Clear Itch Relief Evora Labs Band Aid Antiseptic Cleansing Hemorrhoidal Pain Relief Polysporin Itch Relief Topcare Antibiotic Premier Value Triple Antibiotic Plus Clear Itch Relief Topcare Hemorrhoidal Caladryl Clear Gold Bond Medicated Anti-itch Cream Good Sense Triple Antibiotic and Pain Relief Up and Up Antibiotic Plus Pain Relief Itch Relief Medicated Pads CVS TopCare Antibiotic Plus Pain Relief Neosporin Plus Pain Relief Clubtray Calamine GNP Caldyphen Pramosone E Calamine Plus Pramoxine HCL Analpram E Polysporin Poly To Go Cortaine -B Aqueous Aveeno Anti Itch Concentrated Dual Action Cream Basic Care First Aid Antibiotic Anuzinc Plus Suppositories Antibiotic and pain relief maximum strength Quality Choice Anti-itch Medicated TopCare Triple Antibiotic Plus Pain Relief Gold Bond Anti-itch Lotion Smart Sense Antibiotic Maximum Strength Blistex Cold and Allergy Lip Soother HEB Calaclear Triple Antibiotic Plus Hemorrhoidal Ointment Pramoxine hydrochloride TopCare Calaclear Best Choice Medicated Calamine CVS Pharmacy Maximum Strength Feminine Wipes Itch Relief Lotion CVS Calamine Plus Leader Triple Antibiotic Plus Aveeno Anti-Itch Concentrated Neosporin Plus Pain Relief Neo To Go First Aid Antibiotic Pain Relieving Premier Value Max Strength Antibiotic plus pain relief Reeses Pinworm Itch Relief Sandoz Anuzinc Plus Vida Mia Calaclear First Aid Antibiotic and Pain Relief First Aid Antibiotic Bacitraycin Plus Maximum Strength Walgreens Maximum Strength Hemorrhoidal Double Antibiotic Plus Pain Relief Maximum Strength Antibiotic plus Pain Relief SIMPLE PROMISE Simple H Hemorrhoid Relief Cream Sunmark Antibiotic Plus Pain Relief Bite and Itch Exchange Select First Aid Triple Anitbiotic Pain Relieving Neosporin Plus Pain Relief Atopalm First Aid Triple Antibiotic plus Pain Relief LEADER Caldyphen Clear Bactine Pain Relieving Cleansing Spray Prax Hydro Ear Hydrocortisone Acetate 2.5% Pramoxine HCl 1% NATUREPLEX ANTIBIOTIC plus PAIN RELIEF Tucks Fast Relief Best Choice Medicated anti itch Rite Aid Cala Itch Relief TheraCare Triple Antibiotic Pain Relief Signature Care Hemorrhoidal Cream (with applicator) Rite Aid Soothing Medicated Anit-Itch Triple antibiotic and pain relief Analpram Advanced Triple Antibiotic and Burn Relief PrameGel Welly Bravery First Aid Kit meijer Antibiotic Plus Pain Relief Humco Calaclear Oncoderm ItchRx Private Label Poison Ivy Wash Rexall Hemorrhoidal Care One Maximum Strength First Aid Antibiotic Good Sense Triple Antibiotic Up and Up First Aid Antibiotic Pain Relieving Shopko Triple Antibiotic plus Pain Relief CVS Health Triple Antibiotic with Pain Relief Equaline Antibiotic Plus Pain Relief CVS Health Maximum Strength Feminine Hemorrhoidal Triple Antibiotic Plus Pain Relief Maximum Strength OLP Triple Antibiotic Plus Natureplex Antibiotic Plus Pain, Itch, Scar Relief Oto End 10 Pramosone Cream Dermagesic DG Health Medicated Anti-Itch Analgesic Welly Bravery Triple Antibiotic with Pain Relief Soothing Care Itch Relief Spray Smart Sense Triple Antibiotic Tronothane Pramoxine HCl Crm 1% USP Oticin HC Ear Drops Equaline Antibiotic Plus Pain Relief for Kids Good Sense Hemorrhoidal Maximum Strength Pain Relief Triple Antibiotic plus pain relief Bikini Zone MEDICATED After Shave Fresh Scent Equaline Triple Antibiotic Plus First Aid Triple Antibiotic and Pain Relief Maximum Strength Good Neighbor Pharmacy Triple Antibiotic Plus Pain Relief Hydrocortisone Acetate Pramoxine HCl Up and Up multi action antibiotic Equate Antibiotic Plus Pain Relief Anti-Itch Wipes Walgreen Anti-Itch Pro-relief Walgreens Multi-Antibiotic with Pain Relief Cream Live Better Triple Antibiotic plus Pain Relief Atopalm First Aid Triple Antibiotic Protection Moisturizing and Pain Relief Equaline Triple Antibiotic Topcare Triple Antibiotic Triple Antibiotic hydrocortisone acetate pramoxine HCl Analpram E Cream 2.5% Kit hydrocortisone acetate 2.5% pramoxine hydrochloride 1% Dg Health Triple Antibiotic DG Health Antibiotic Select Brand Calaclear Pentrexcilina Triple Antibiotic Plus Pain Relief Healthy Accents Triple Antibiotic Itch Relief Clear Skin Protectant CVS Oti Rx Galentic Triple Antibiotic Plus Pain Relief Antibiotic CVS Pharmacy Pramcort Dermarest Eczema Medicated Moist for Sensitive Skin Premier Value Calaclear Johnson and Johnson All Purpose First Aid Kit QC Medicated anti itch AVON HeXashield Triple Antibiotic with Pain Relief Vagisil Medicated Wipes Natureplex Antibiotic plus Pain First Aid Antibiotic plus Burn Relief Sarna Neosporin Plus Pain Relief First Aid Antibiotic/Pain Relieving Pramoxine Itch relief Proctofoam Antibiotic and Pain Relief Hemorrhoidal Cream Antibiotic and Pain Relief Maximum Strength Anti Itch Maximum Relief Cuadriderma Neosporin Plus Pain Relief Neo to Go Triple Antibiotic and Pain Relief Maximum Strength CVS Itch Relief DerMend Moisturizing Anti-Itch meijer Triple Antibiotic plus Pain Relief Basic Care First Aid Antibiotic Plus Pain Relief CeraVe Developed with Dermatologists Itch Relief Moisturizing Family Care Triple Antibiotic Plus Pain Relief CeraVe Itch Relief Moisturizing Careone Triple Antibiotic Calaclear Quality Choice Anti-Itch Clear Shoprite Triple Antibiotic Family Care Maximum Strength Medicated Anti Itch Triple antibiotic and pain itch scar Anesthetic Hemorrhoidal With Aloe Prax Wipe CVS Hemorrhoidal NEOSPORIN Plus BURN RELIEF Prosoria Anti-Itch Moisturizer Signature Care Triple Antibiotic Hemorrhoidal Anesthetic Harris Teeter Triple Antibiotic Plus Pain Relief Anuzinc HC Plus Sunmark Hemorrhoidal Anusol Plus Suppositories Shopko Antibiotic Plus Pain Relief Bikini Zone Medicated After-shave Roll-ON Relief Select Brand Anti-Itch Publix antibiotic plus Pain Relief Sheffield Triple Antibiotic Plus Pain Relief Family Wellness Pain Scar Itch WinCo Maximum Strength Triple Antibiotic Basic Care First Aid Antibiotic and Burn Relief Up and Up Hemorrhoidal Honey Pot Walgreens Maximum Strength Triple Antibiotic With Pain Relief Ear Itch MD Hemorrhoidal Maximum Strength Pain Relief Poison Ivy Wash Novacort CAREONE Antibiotic Plus Pain Relief H E Buddy Antibiotic Maximum Strength Plus Pain Relief W15883-CS Itch Relief Moisturizing Cream Quality Choice Maximum Strength Triple Antibiotic Caladryl CVS Medicated Anti-Itch Hemorrhoidal Relief Curad Maximum Strength Triple Antibiotic HEB Calagesic Equate First Aid Antibiotic Plus Pain Relief Equate Antibiotic Plus Pain, Itch, Scar Relief VAGISIL Anti-Itch Medicated Wipes Maximum Strength Premier Value Antibiotic Plus Pain Relief LiveBetter Antibiotic Plus Pain Relief Triple Antibiotic Plus Pain Relief Anugesic-HC Ointment Equate First Aid Antibiotic Pain Relieving Tucks Hemorrhoidal First Aid Clear Anti-Itch medicated pads Rite Aid Cortane-B Sally Hansen Zero bump bikini Itch Relief Balm Drs. Pharmacy Triple Antibiotic Plus Anodan-plus DCH Calaspray Itch Relief Calamine Clear Analpram HC Signature Care Hemorrhoidal Aveeno Anti-itch Lotion Bi-Mart Triple Antibiotic plus Pain Relief Itch X Gel CVS Maximum Strength Feminine Anti-Itch Wipes First On Topical Analgesic Aveeno Restorative Skin Therapy Itch Relief Balm CVS Medicated anti itch Proctofoam NS Calamine Plus Pramoxine HCl Sunmark Triple Antibiotic Plus Pain Relief Neosporin Kids Plus Pain Relief Triple Antibiotic and Pain Relief CVS Anti-Itch Pramosone Extra Strength Bacitraycin Plus First Aid Antiseptic Pain Relieving Meijer Antibiotic Plus Pain Relief PREPARATION H Maximum Strength Hydrocortisone Acetate and Pramoxine Hydrochloride Publix antibiotic plus pain relief Hemorrhoidal Ointment With Anesthetic for Extra Pain Relief Sunmark Caldiphen Johnson and Johnson First Aid Travel Ready 80 CT Triple Antibiotic Plus Maximum Strength Neosporin Plus Pain Relief Neo To Go First Aid Antiseptic Pain Relieving For Kids Leader Poison Ivy Wash Pain Relief First Aid Maximum Strength Bacitraycin Plus Leader Triple Antibiotic and Pain Relief Tripleantibioticointmentandpainrelief Itch X Bikini Zone Medicated After Shave Spray Itch-X Gel Fissurene HC Pram Bacitraycin Plus Acella Hydrocortisone Acetate - Pramoxine Singles Dr. Sheffield Hemorrhoid Aveeno Active Naturals Skin Relief Medicated Anti Itch Treatment Calamine Plus Family Wellness Triple Antibiotic Plus Pain Relief Pramoxine Hydrochloride Proctofoam HC Smart Sense antibiotic plus pain relief Band Aid Antiseptic Cleansing To Go Preferred Plus Hemorrhoid Curasore Tronolane Glycerin, Phenylephrine Hydrochloride, Pramoxine, White Petrolatum Family Wellness Anusol Plus Ointment ATOPALM Hemorrhoidal Pain Relieving Signature Care First Aid Antibiotic ZyPram Johnson and Johnson First Aid All Purpose 160 CT Premier Value Calagesic Penimixcina MAXIMUM STRENGTH MEDICATED ANTI-ITCH Rite Aid Pomada De La Campana Triple Antibiotic Pain Relief Pramox HC Cream Gold Bond Intensive Healing Anti Itch Skin Protectant
Indication	It is indicated for temporary relief of pain and pruritus from minor lip and skin irritations as well as for temporary relief from pain, burning, itching and discomfort associated with hemorrhoids and other anorectal/anogenital disorders.
Categories	Agents for Treatment of Hemorrhoids and Anal Fissures for Topical Use Anesthetics Anesthetics for Topical Use Anesthetics, Local Antipruritics and Local Anesthetics Antipruritics, Incl. Antihistamines, Anesthetics, Etc. Central Nervous System Agents Central Nervous System Depressants Dermatologicals Oxazines Peripheral Nervous System Agents Sensory System Agents Vasoprotectives
ATC-Code	D04AB07 C05AD07
CAS number	140-65-8

Drug Targets

Name	Target Sequence	Pharmacological Action	Actions
Voltage-gated sodium channel alpha subunit	MEQTVLVPPGPDSFNFFTRESLAAIERRIAEEKAKNPKPDKKDDDENGPK...	unknown	blocker

Drug Info/Drug Targets: DrugBank 3.0: a comprehensive resource for 'omics' research on drugs. Knox C, Law V, Jewison T, Liu P, Ly S, Frolkis A, Pon A, Banco K, Mak C, Neveu V, Djoumbou Y, Eisner R, Guo AC, Wishart DS. Nucleic Acids Res. 2011 Jan; 39 (Database issue):D1035-41. | PMID:21059682