ROL

ROLIPRAM

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is present as a standalone ligand in 9 entries

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Chemical Component Summary
Name	ROLIPRAM
Synonyms	(4R)-[3-(CYCLOPENTYLOXY)-4-METHOXYPHENYL]-2-PYRROLIDINONE
Identifiers	(4R)-4-(3-cyclopentyloxy-4-methoxy-phenyl)pyrrolidin-2-one
Formula	C₁₆ H₂₁ N O₃
Molecular Weight	275.343
Type	NON-POLYMER
Isomeric SMILES	COc1ccc(cc1OC2CCCC2)[C@H]3CC(=O)NC3
InChI	InChI=1S/C16H21NO3/c1-19-14-7-6-11(12-9-16(18)17-10-12)8-15(14)20-13-4-2-3-5-13/h6-8,12-13H,2-5,9-10H2,1H3,(H,17,18)/t12-/m0/s1
InChIKey	HJORMJIFDVBMOB-LBPRGKRZSA-N

Chemical Details
Formal Charge	0
Atom Count	41
Chiral Atom Count	1
Bond Count	43
Aromatic Bond Count	6

Drug Info: DrugBank

DrugBank ID	DB04149
Name	(R)-Rolipram
Groups	experimental
Description	The (R)-enantiomer of rolipram, it is a phosphodiesterase inhibitor with antidepressant properties.
Synonyms	(R)-Rolipram (−)-rolipram (R)-(−)-rolipram (R)-4-(3-Cyclopentyloxy-4-methoxy-phenyl)-pyrrolidin-2-one (R)-(-)-rolipram R-rolipram
CAS number	85416-75-7

Drug Targets

Name	Target Sequence	Pharmacological Action	Actions
cAMP-specific 3',5'-cyclic phosphodiesterase 4B	MKKSRSVMTVMADDNVKDYFECSLSKSYSSSSNTLGIDLWRGRRCCSGNL...	unknown	inhibitor
cAMP-specific 3',5'-cyclic phosphodiesterase 4D	MEAEGSSAPARAGSGEGSDSAGGATLKAPKHLWRHEQHHQYPLRQPQFRL...	unknown

Drug Info/Drug Targets: DrugBank 3.0: a comprehensive resource for 'omics' research on drugs. Knox C, Law V, Jewison T, Liu P, Ly S, Frolkis A, Pon A, Banco K, Mak C, Neveu V, Djoumbou Y, Eisner R, Guo AC, Wishart DS. Nucleic Acids Res. 2011 Jan; 39 (Database issue):D1035-41. | PMID:21059682