SPR

SPIRAMYCIN I

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as a non-polymer is covalently linked to polymer or other heterogen groups 1 entries

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Chemical Component Summary
Name	SPIRAMYCIN I
Identifiers	2-[(4R,5S,6S,7R,9R,10R,11E,13E,16R)-6-[(2S,3R,4R,5S,6R)-5-[(2S,4R,5S,6S)-4,5-dihydroxy-4,6-dimethyl-oxan-2-yl]oxy-4-dimethylamino-3-hydroxy-6-methyl-oxan-2-yl]oxy-10-[(2R,5S,6R)-5-dimethylamino-6-methyl-oxan-2-yl]oxy-4-hydroxy-5-methoxy-9,16-dimethyl-2-oxo-1-oxacyclohexadeca-11,13-dien-7-yl]ethanal
Formula	C₄₃ H₇₄ N₂ O₁₄
Molecular Weight	843.053
Type	NON-POLYMER
Isomeric SMILES	C[C@@H]1C\C=C\C=C\[C@@H]([C@@H](C[C@@H]([C@@H]([C@H]([C@@H](CC(=O)O1)O)OC)O[C@H]2[C@@H]([C@H]([C@@H]([C@H](O2)C)O[C@H]3C[C@@]([C@H]([C@@H](O3)C)O)(C)O)N(C)C)O)CC=O)C)O[C@H]4CC[C@@H]([C@H](O4)C)N(C)C
InChI	InChI=1S/C43H74N2O14/c1-24-21-29(19-20-46)39(59-42-37(49)36(45(9)10)38(27(4)56-42)58-35-23-43(6,51)41(50)28(5)55-35)40(52-11)31(47)22-33(48)53-25(2)15-13-12-14-16-32(24)57-34-18-17-30(44(7)8)26(3)54-34/h12-14,16,20,24-32,34-42,47,49-51H,15,17-19,21-23H2,1-11H3/b13-12+,16-14+/t24-,25-,26-,27-,28+,29+,30+,31-,32+,34+,35+,36-,37-,38-,39+,40+,41+,42+,43-/m1/s1
InChIKey	ACTOXUHEUCPTEW-CEUOBAOPSA-N

Chemical Details
Formal Charge	0
Atom Count	133
Chiral Atom Count	19
Bond Count	136
Aromatic Bond Count	0

Drug Info: DrugBank

DrugBank ID	DB06145
Name	Spiramycin
Groups	approved
Description	Spiramycin is a primarily bacteriostatic macrolide antimicrobial agent with activity against Gram-positive cocci and rods, Gram-negative cocci and also Legionellae, mycoplasmas, chlamydiae, some types of spirochetes, Toxoplasma gondii and Cryptosporidium. Spiramycin is a 16-membered ring macrolide discovered in 1952 as a product of Streptomyces ambofaciens that has been available in oral formulations since 1955, and parenteral formulations since 1987. Resistant organisms include Enterobacteria, pseudomonads, and moulds.
Synonyms	Spiramycin Demycarosylturimycin H Spiramycin I Foromacidin A Foromacidine A Spiramycin 1 Spiramycin A
Brand Names	Rovamycine 500 Capsule 1500000 Unit Rovamycine 250 Capsule 750000 Unit
Indication	Macrolide antibiotic for treatment of various infections.
Categories	Anti-Bacterial Agents Anti-Infective Agents Antibacterials for Systemic Use Antiinfectives for Systemic Use Antiparasitic Agents Antiprotozoals Carbohydrates Coccidiostats Cytochrome P-450 CYP3A Inhibitors Cytochrome P-450 Enzyme Inhibitors Glycosides Lactones Leucomycins Macrolide Antimicrobial Macrolides Macrolides, Lincosamides and Streptogramins Polyketides
ATC-Code	J01RA04 J01FA02
CAS number	24916-50-5

Drug Targets

Name	Target Sequence	Pharmacological Action	Actions
50S ribosomal protein L3	MTKGILGKKVGMTQIFTESGEFIPVTVIEATPNVVLQVKTVETDGYEAVQ...	unknown	antagonist,inhibitor

Drug Info/Drug Targets: DrugBank 3.0: a comprehensive resource for 'omics' research on drugs. Knox C, Law V, Jewison T, Liu P, Ly S, Frolkis A, Pon A, Banco K, Mak C, Neveu V, Djoumbou Y, Eisner R, Guo AC, Wishart DS. Nucleic Acids Res. 2011 Jan; 39 (Database issue):D1035-41. | PMID:21059682