Chemical Component Summary

NameTRICLOSAN
Identifiers5-chloro-2-(2,4-dichlorophenoxy)phenol
FormulaC12 H7 Cl3 O2
Molecular Weight289.542
TypeNON-POLYMER
Isomeric SMILESc1cc(c(cc1Cl)O)Oc2ccc(cc2Cl)Cl
InChIInChI=1S/C12H7Cl3O2/c13-7-1-3-11(9(15)5-7)17-12-4-2-8(14)6-10(12)16/h1-6,16H
InChIKeyXEFQLINVKFYRCS-UHFFFAOYSA-N

Chemical Details

Formal Charge0
Atom Count24
Chiral Atom Count0
Bond Count25
Aromatic Bond Count12

Drug Info: DrugBank

DrugBank IDDB08604 
NameTriclosan
Groups
  • approved
  • investigational
DescriptionAn aromatic ether that is phenol which is substituted at C-5 by a chloro group and at C-2 by a 2,4-dichlorophenoxy group. It is widely used as a preservative and antimicrobial agent in personal care products such as soaps, skin creams, toothpaste and deodorants as well as in household items such as plastic chopping boards, sports equipment and shoes.
Synonyms
  • 5-Chloro-2-(2,4-dichloro-phenoxy)-phenol
  • 2,4,4'-Trichloro-2'-hydroxydiphenyl ether
  • Triclosán
  • Triclosanum
  • Triclosan
Brand Names
  • First Aid Cream 0.5%
  • First Mark Foam Antimicrobial Hand Cleaner
  • Sentry Antibac
  • Avocado Antibacterial Hand Wash
  • Bacto Liq 0.2%
IndicationTriclosan is used in a variety of common household products, including soaps, mouthwashes, dish detergents, toothpastes, deodorants, and hand sanitizers. It is also used in health care settings in surgical scrubs and personnel hand washes.
Categories
  • Anti-Infective Agents
  • Anti-Infective Agents, Local
  • Antiseptics and Disinfectants
  • Benzene Derivatives
  • Dermatologicals
ATC-Code
  • D08AE04
  • D09AA06
CAS number3380-34-5

Drug Targets

NameTarget SequencePharmacological ActionActions
Enoyl-[acyl-carrier-protein] reductase [NADH] FabIMGFLSGKRILVTGVASKLSIAYGIAQAMHREGAELAFTYQNDKLKGRVEE...unknown
Enoyl-[acyl-carrier-protein] reductase [NADH]MTGLLDGKRILVSGIITDSSIAFHIARVAQEQGAQLVLTGFDRLRLIQRI...unknown
Enoyl-[acyl-carrier-protein] reductase [NADH] FabIMGFLKGKKGLIVGVANNKSIAYGIAQSCFNQGATLAFTYLNESLEKRVRP...unknown
Enoyl-[acyl-carrier-protein] reductase [NADH]MELLQGKTFVVMGVANQRSIAWGIARSLHNAGAKLIFTYAGERLERNVRE...unknown
Enoyl-[acyl-carrier-protein] reductase [NADPH] FabIMLNLENKTYVIMGIANKRSIAFGVAKVLDQLGAKLVFTYRKERSRKELEK...unknown
View More
Drug Info/Drug Targets: DrugBank 3.0: a comprehensive resource for 'omics' research on drugs. Knox C, Law V, Jewison T, Liu P, Ly S, Frolkis A, Pon A, Banco K, Mak C, Neveu V, Djoumbou Y, Eisner R, Guo AC, Wishart DS. Nucleic Acids Res. 2011 Jan; 39 (Database issue):D1035-41. | PMID:21059682

Related Resource References

Resource NameReference
Pharos CHEMBL849
PubChem 5564
ChEMBL CHEMBL849
ChEBI CHEBI:164200
CCDC/CSD QUBQIO01, QUBQIO
COD 2017232