A methylxanthine derivative from tea with diuretic, smooth muscle relaxant, bronchial dilation, cardiac and central nervous system stimulant activities. Mechanistically, theophylline acts as a phosphodiesterase inhibitor, adenosine receptor blocker, and histone deacetylase activator. Theophylline is marketed under several brand names such as Uniphyl and Theochron, and it is indicated mainly for asthma, bronchospasm, and COPD.
Synonyms
Teofilina
Theophyllin
Theophylline sodium glycinate
1,3-dimethyl-7H-purine-2,6-dione
Theophylline
Theophylline, anhydrous
1,3-dimethylxanthine
Theophylline anhydrous
Brand Names
Theo-dur 100 mg
Theolair SR Tab 250mg
Theochron Srt 200mg
Theophylline 1.6mg and 5% Dextrose Inj
Pulmophylline Elx
Theophylline
Slo-bid 300
Theophylline Elixir
Theophylline 0.8mg and 5% Dextrose Inj
Tedral Tab
Elixophyllin
Senophylline
Slo-bid 100
Theophylline(Anhydrous)
Theolair Tab 250mg
Theochron Srt 300mg
I D M Expectorant Tab
Quibron T/SR
Theo-dur 450 mg
Theolair SR Tab 200mg
Theophylline in Dextrose
Slo-bid 50
Theophylline 4mg and 5% Dextrose Inj
Theochron Srt 100mg
Ratio-theo-bronc
Theolair
Theolair SR Tab 500mg
Theolair SR Tab 300mg
Uniphyl
Theo-dur 300 mg
Apo-theo ER
Theo-SR 300 Srt 300mg
Theophylline 0.8mg/ml In 5% Dextrose Inj
Theolair Tab 125mg
Theophylline Elx
Aa-theo LA
Theophylline Anhydrous
Slo-bid 200
Elixir De Theophylline
Idm Tab
Quibron T SR Tab 300mg
Quibron-T
Theophylline (Anhydrous)
Theophylline Extended Release
Theophylline 80mg/15ml
Theo-dur 200 mg
Theo-24
PMS-theophylline Elixir
Theo ER
Theophylline Rougier Elixir
Teva-theophylline SR
Indication
For the treatment of the symptoms and reversible airflow obstruction associated with chronic asthma and other chronic lung diseases, such as emphysema and chronic bronchitis.
Categories
Agents that reduce seizure threshold
Alkaloids
Anti-Asthmatic Agents
Autonomic Agents
Bronchodilator Agents
Cardiovascular Agents
Cytochrome P-450 CYP1A2 Substrates
Cytochrome P-450 CYP1A2 Substrates with a Narrow Therapeutic Index
Cytochrome P-450 CYP2C8 Substrates
Cytochrome P-450 CYP2D6 Substrates
Cytochrome P-450 CYP2D6 Substrates with a Narrow Therapeutic Index
Cytochrome P-450 CYP2E1 Substrates
Cytochrome P-450 CYP2E1 Substrates with a Narrow Therapeutic Index
Cytochrome P-450 CYP3A Substrates
Cytochrome P-450 CYP3A4 Substrates
Cytochrome P-450 CYP3A4 Substrates with a Narrow Therapeutic Index
Drug Info/Drug Targets: DrugBank 3.0: a comprehensive resource for 'omics' research on drugs. Knox C, Law V, Jewison
T, Liu P, Ly S, Frolkis A, Pon A, Banco K, Mak C, Neveu V, Djoumbou Y, Eisner R, Guo AC, Wishart DS.
Nucleic Acids Res. 2011 Jan; 39 (Database issue):D1035-41. | PMID:21059682