THR

THREONINE

Find entries where: THR

is present as a standalone ligand in 33 entries

as a non-polymer is covalently linked to polymer or other heterogen groups 17 entries

is present in a polymer sequence 219,527 entries

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Chemical Component Summary
Name	THREONINE
Identifiers	(2S,3R)-2-amino-3-hydroxy-butanoic acid
Formula	C₄ H₉ N O₃
Molecular Weight	119.119
Type	L-PEPTIDE LINKING
Isomeric SMILES	C[C@H]([C@@H](C(=O)O)N)O
InChI	InChI=1S/C4H9NO3/c1-2(6)3(5)4(7)8/h2-3,6H,5H2,1H3,(H,7,8)/t2-,3+/m1/s1
InChIKey	AYFVYJQAPQTCCC-GBXIJSLDSA-N

Chemical Details
Formal Charge	0
Atom Count	17
Chiral Atom Count	2
Bond Count	16
Aromatic Bond Count	0

Drug Info: DrugBank

DrugBank ID	DB00156
Name	Threonine
Groups	approved nutraceutical
Description	An essential amino acid occurring naturally in the L-form, which is the active form. It is found in eggs, milk, gelatin, and other proteins.
Synonyms	L-alpha-amino-beta-hydroxybutyric acid Threonine 2-Amino-3-hydroxybutyric acid Thr L-2-Amino-3-hydroxybutyric acid (2S)-threonine (2S,3R)-(-)-Threonine Treonina L-Threonine Threoninum L-Threonin L-(-)-Threonine L-α-amino-β-hydroxybutyric acid
Brand Names	Aminosyn II 8.5% With 50% Dextrose Quick Mix 2.5% Travasol Aa With Electrolytes With 25% Dextrose Injec Hepatasol 20% Prosol 4.25% Travasol Amino Acid Injection Without Electrolytes In 20% Dextrose Smofkabiven Electrolyte Free Travasol Amino Acid Inj 8.5% Aminosyn II 7% M In 10% Dextrose(dual Chamber) Aminosyn-PF 10% Aminosyn Aminosyn 10% W Electrolytes Travasol Aminosyn II 10% With Electrolytes Aminosyn RF Olimel 7.6% Primene 10%-liq IV 2.75% Travasol Amino Acid Injection With Electrolytes In 5% Dextrose Quickmix Clinimix 2.5% Travasol Aa Without Electrolytes In 10% Dextrose Injec TrophAmine 2.75% Travasol Amino Acid Injection With Electrolytes In 25% Dextrose Quickmix Novamine Smofkabiven Aminosyn II with Electrolytes Olimel 5.7% Smofkabiven Extra Nitrogen Olimel 4.4% E 5% Travasol Amino Acid Injection Without Electrolytes In 20% Dextrose Clinimix 4.25% Travasol Amino Acid Injection With Electrolytes In 20% Dextrose Aminosyn 7% 2.5%travasol Amino Acid InJ.W.eleC.W.25%dex 2.75% Travas. Amino Acid InJ.W.elecw.25%dex Travasol Amino Acid Inj 5.5% 4.25% Travasol Amino Acid Without Electrolytes In 5% Dextrose Quickmix Travasol Inj Without Electrolytes 5.5% Aminosyn 8.5% Injection With Electrolytes Cicatrin Powder FreAmine III Primene 4.25%travasol Amino Acid InJ.W.elecw.5%dex. Aminoderm Poudre Synthamin HepatAmine 4.25% Travasol Amino Acid Injection With Electrolytes In 20% Dextrose Quickmix Clinimix E 4.25% Travasol Amino Acid Injection Without Electrlytes In 10% Dextrose Olimel 4.4% 5% Travasol Amino Acid Injection With Electrolytes In 20% Dextrose Premasol - sulfite-free (Amino Acid) Aminosyn 8.5% 2.5% Travasol Amino Acid Injection With Electrolytes In 10% Dextrose Olimel 7.6% E 4.25% Amino Acid Injection Without Electrolytes In 20% Dextrose Quickmix 4.25% Travasol Amino Acid Injection With Electrolytes In 5% Dextrose Quickmix NephrAmine Periolimel 2.5% E Travasol Inj Without Electrolytes 8.5% ProcalAmine 4.25%trav. Amino Acid InJ.W.O.elect.5%dext. Primene 10% Aminosyn Sulfite Free Clinisol Olimel 3.3% E Aminosyn II Aminosyn HF Smofkabiven Extra Nitrogen Electrolyte Free Plenamine Aminosyn II 5% Inj 4.25% Travasol Amino Acid Injection With Electrolytes In 10% Dextrose ProSol Aminosyn II 8.5% Injection 2.75%travasol Amino Acid InJ.W.eleC.W.5%dex. Aminosyn II In Dextrose Injection Olimel 5.7% E Perikabiven Aminosyn II with Electrolytes in Dextrose with Calcium Aminosyn-PF Aminosyn II 8.5% M In 20% Dextrose (dual Chamber) 4.25% Travasol Amino Acid Injection Without Electrolytes In 25% Dextrose Aminosyn 3.5% M Vamin 18 Electrolyte-free Aminosyn-PF 7% Vamin N 5% Travasol Amino Acid Injection Without Electrolytes In 25% Dextrose Kabiven Smofkabiven Peripheral 4.25% Travasol Amino Acid Injection With Electrolytes In 25% Dextrose Travasol E Renamin (amino Acids) Injection Nutrineal Pd4 2.5% Travasol Amino Acid Injection With Electrolytes In 10% Dextrose Clinimix Aminosyn II 7% With 10% Dextrose Aminosyn II 7% With 50% Dextrose FreAmine HBC Nephramine Liq IV Aminosyn II and Dextrose 8.5% Freamine III Aminosyn II in Dextrose Essepna Aminosyn 5% RenAmin Aminosyn RF Injection 2.5% Travasol Amino Acid Injection Without Electrolytes In 10% Dextrose Quickmix Aminosyn II 7% Injection
Indication	L-Threonine makes up collagen, elastin, and enamel protein. It aids proper fat metabolism in the liver, helps the digestive and intestinal tracts function more smoothly, and assists in metabolism and assimilation.
Categories	Amino Acids Amino Acids, Essential Amino Acids, Neutral Amino Acids, Peptides, and Proteins Dietary Supplements Proteinogenic Amino Acids Supplements Threonine, antagonists & inhibitors
CAS number	72-19-5

Drug Targets

Name	Target Sequence	Pharmacological Action	Actions
Threonine--tRNA ligase, cytoplasmic	MFEEKASSPSGKMGGEEKPIGAGEEKQKEGGKKKNKEGSGDGGRAELNPW...	unknown
Threonine--tRNA ligase, mitochondrial	MALYQRWRCLRLQGLQACRLHTAVVSTPPRWLAERLGLFEELWAAQVKRL...	unknown
Beta-lactamase Toho-1	MMTQSIRRSMLTVMATLPLLFSSATLHAQANSVQQQLEALEKSSGGRLGV...	unknown	unknown
Monocarboxylate transporter 10	MVLSQEEPDSARGTSEAQPLGPAPTGAAPPPGPGPSDSPEAAVEKVEVEL...	unknown	inhibitor

Drug Info/Drug Targets: DrugBank 3.0: a comprehensive resource for 'omics' research on drugs. Knox C, Law V, Jewison T, Liu P, Ly S, Frolkis A, Pon A, Banco K, Mak C, Neveu V, Djoumbou Y, Eisner R, Guo AC, Wishart DS. Nucleic Acids Res. 2011 Jan; 39 (Database issue):D1035-41. | PMID:21059682