Nitroglycerin, also known as glyceryl trinitrate,[A180169] is an organic nitrate and a vasodilating agent [L38369] that was first discovered in 1847.[A249965] Originally used to dynamite, its antianginal effects were identified in the late 1860s after it produced headaches in factory workers while workers with angina pectoris or heart failure experienced relief from chest pain.[A180166,A180172] Its use as a treatment for angina dates back to 1879 and is still used to treat and prevent angina.[A249970] Nitroglycerin causes vasodilation in both arteries and veins.[A180172] Nitroglycerin is used in a variety of different conditions, including angina pectoris due to coronary artery disease,[L7102,L7141,L38369,L42320] peri-operative hypertension, congestive heart failure,[L7099] and chronic anal fissure.[L42445] It is also used to induce intraoperative hypotension.[L7099]
Synonyms
NG
Propane-1,2,3-triyl trinitrate
Glycerol, nitric acid triester
Nitroglycerol
Glycerol trinitrate
Glyceryl trinitrate
Nitroglycerine
Nitroglicerina
Trinitroglycerol
Glyceroli trinitratis
Trinitrine
Glycerin trinitrate
Trinitroglycerin
Nitromed
Nitroglycerin
1,2,3-propanetriyl nitrate
Glyceroltrinitrat
1,2,3-propanetrioltrinitrate
Brand Names
Nitroglycerin In 5% Dextrose Inj.-100mcg/ml
Nitrolingual Spray 0.4mg/eam
Nitrogard-SR Tab 1mg
Nitrong SR Srt 2.6mg
Transderm-nitro 0.6
Nitroglycerin Injection USP
Nitroglycerin ER
Nitroglycerin Inj 5mg/ml
Nitroglycerin
Minitran - Patch Trd 72mg/26.6 Sq Cm
Mylan-nitro Patch 0.4
Nitro-Time
Nitrolingual Pumpspray
Basic Dental Emergency Kit
Nitroject
Transderm Nitro
Nitroglycerin Transdermal Delivery System
Nitro-dur 0.6
Nitroglycerin In 5% Dextrose Inj.-400mcg/ml
Nitrostat
Nitronal
Mylan-nitro Sublingual Spray
Rho-nitro Pumpspray
Nitrolingual
Tridil Injection 5mg/ml
Trinipatch 0.6
Trinipatch 0.2
Nitroglycerin Transdermal Infusion System
Mylan-nitro Patch 0.8
Nitroject Inj 1mg/ml
Nitro-time
Nitroglycerin Lingual
Rectiv
Deluxe Dental Emergency Kit
Nitroglycerin in Dextrose
Transderm-nitro 0.8
Nitrol
NitroMist
Nitroglycerin SR
Nitroglycerin Transdermal System
Nitro-dur 0.4
Apo-nitroglycerin
Nitro-dur 0.3 - 60mg/15 Sq Cm, 0.3mg/hr
Trinipatch 0.4
Nitroglycerin Slocaps
Nitroglycerin In 5% Dextrose Inj.-200mcg/ml
Minitran
Mylan-nitro Patch 0.6
Transderm-nitro 0.4
Mylan-nitro Patch 0.2
Nitro-bid
Nitro-dur
Nitro-dur 0.8
Nitro-dur 0.2
Gonitro
Nitroglycerin In Dextrose
Transderm-nitro 0.2
Indication
Sublingual nitroglycerin is indicated for the acute relief of an attack or acute prophylaxis of angina pectoris due to coronary artery disease.[L7102,L38369,L42320] Transdermal nitroglycerin is indicated for the prevention of angina pectoris due to coronary artery disease.[L7141] Intravenous nitroglycerin is indicated for the treatment of peri-operative hypertension; for control of congestive heart failure in the setting of acute myocardial infarction; for treatment of angina pectoris in patients who have not responded to sublingual nitroglycerin and beta (β)-blockers; and for induction of intraoperative hypotension.[L7099] Topical nitroglycerin ointment is used to treat moderate to severe pain associated with chronic anal fissure.[L42445]
Categories
Agents for Treatment of Hemorrhoids and Anal Fissures for Topical Use
Antianginal Agents
Antihypertensive Agents
Cardiac Therapy
Cardiovascular Agents
Compounds used in a research, industrial, or household setting
Drug Info/Drug Targets: DrugBank 3.0: a comprehensive resource for 'omics' research on drugs. Knox C, Law V, Jewison
T, Liu P, Ly S, Frolkis A, Pon A, Banco K, Mak C, Neveu V, Djoumbou Y, Eisner R, Guo AC, Wishart DS.
Nucleic Acids Res. 2011 Jan; 39 (Database issue):D1035-41. | PMID:21059682
