Trimethoprim is an antifolate antibacterial agent that inhibits bacterial dihydrofolate reductase (DHFR), a critical enzyme that catalyzes the formation of tetrahydrofolic acid (THF) - in doing so, it prevents the synthesis of bacterial DNA and ultimately continued bacterial survival.[L11893] Trimethoprim is often used in combination with [sulfamethoxazole] due to their complementary and synergistic mechanisms but may be used as a monotherapy in the treatment and/or prophylaxis of urinary tract infections.[L11893,L11830] It is structurally and chemically related to [pyrimethamine], another antifolate antimicrobial used in the treatment of plasmodial infections.[T707]
Sulfamethoxazole and Trimethoprim for Injection, USP
Teva-trimel DS
Proloprim Tab 100mg
Sulfamethoxazole and Trimethoprim (Double Strength)
Bactrim DS Roche Tab
Septra
Bactrim Roche Inj
Coptin Oral Suspension
Sandoz Polytrimethoprim
Sulfamethoxazole and Trimethoprim DS
Septra Grape
Sulfamethoxazole and Trimethoprim Double Strength
Trimethoprim Tablets
Riva-sep DS
Primsol
Trimethoprim sulfate and Polymyxin B sulfate
SULFAMETHOXAZOLE and TRIMETHOPRIM
Trisulfa DS Tab
Polymyxin B Sulfate and Trimethoprim Sulfate
Trisulfa Tab
PMS-polytrimethoprim
Septra DS Tablets
Nu-cotrimox Sus 40/8mg/ml
Sulfatrim Pediatric
Sulfameth/Trimeth-DS
Bactrim Roche Suspension Paediatric
Septra DS
Proloprim 200 Tab 200mg
Sulfatrim
sulfamethoxazole-trimethoprim (SMZ)
Nu-cotrimox Tab 400/80mg
Trisulfa S Suspension
Sulfamethox-TMP DS
Sulfamethoxazole and Trimethoprim Tablets
Sulfamethoxazole and Trimethoprim
Proloprim
Teva-trimel
Sulfatrim DS
Septra Pediatric Suspension
Roubac Tab 160/800
Coptin Tab
Septra Injection
Bactrim Roche Tab
Indication
As a monotherapy, trimethoprim is indicated for the treatment of acute episodes of uncomplicated urinary tract infections caused by susceptible bacteria, including _E. coli._, _K. pneumoniae_, _Enterobacter spp._, _P. mirabilis_, and coagulase-negative _Staphylococcus_ species.[L11893,L11890] In various formulations in combination with [sulfamethoxazole], trimethoprim is indicated for the following infections caused by bacteria with documented susceptibility: urinary tract infections, acute otitis media in pediatric patients (when clinically indicated), acute exacerbations of chronic bronchitis in adults, enteritis caused by susceptible _Shigella_, prophylaxis and treatment of _Pneumocystis jiroveci_ pneumonia, and travelers' diarrhea caused by enterotoxigenic _E. coli_.[L11830,L11863] Trimethoprim is available as an ophthalmic solution in combination with [polymyxin B] for the treatment of acute bacterial conjunctivitis, blepharitis, and blepharoconjunctivitis caused by susceptible bacteria.[L11887]
Drug Info/Drug Targets: DrugBank 3.0: a comprehensive resource for 'omics' research on drugs. Knox C, Law V, Jewison
T, Liu P, Ly S, Frolkis A, Pon A, Banco K, Mak C, Neveu V, Djoumbou Y, Eisner R, Guo AC, Wishart DS.
Nucleic Acids Res. 2011 Jan; 39 (Database issue):D1035-41. | PMID:21059682
