Trimethoprim is an antifolate antibacterial agent that inhibits bacterial dihydrofolate reductase (DHFR), a critical enzyme that catalyzes the formation of tetrahydrofolic acid (THF) - in doing so, it prevents the synthesis of bacterial DNA and ultimately continued bacterial survival.[L11893] Trimethoprim is often used in combination with [sulfamethoxazole] due to their complementary and synergistic mechanisms but may be used as a monotherapy in the treatment and/or prophylaxis of urinary tract infections.[L11893,L11830] It is structurally and chemically related to [pyrimethamine], another antifolate antimicrobial used in the treatment of plasmodial infections.[T707]
Sulfamethoxazole and Trimethoprim (Double Strength)
Sulfameth/Trimeth-DS
Trimethoprim
Polymyxin B Sulfate and Trimethoprim Sulfate
Sulfamethoxazole and Trimethoprim DS
Sulfamethoxazole and Trimethoprim for Injection, USP
Roubac Tab 80/400
Sulfamethoxazole and Trimethoprim Injection, BP
Bactrim Roche Inj
Sulfatrim Pediatric
Bactrim
Protrin Df Tab
Primsol
Protrin Tab
SULFAMETHOXAZOLE AND TRIMETHOPRIM double strength
Septra Grape
Polymyxin B Sulfate and Trimethoprim
Septra DS Tablets
Bactrim Roche Suspension Paediatric
Polytrim Ophthalmic Solution
Sulfamethoxazole and Trimethoprim
SULFAMETHOXAZOLE and TRIMETHOPRIM
Proloprim
Polytrim
Nu-cotrimox-DS Tab 800/160mg
Apo-sulfatrim Oral Suspension
Nu-cotrimox Sus 40/8mg/ml
Proloprim 200 Tab 200mg
PMS-polytrimethoprim
Septra Injection
Sulfamethoxazole and Trimethoprim Tablets
Septra Pediatric Suspension
Septra DS
TRIMPEX trimethoprim hydrochloride
POLYMYXIN B SULFATE and TRIMETHOPRIM SULFATE
PrimSol
Bactrim Roche Tab
Sulfamethoxazole and Trimethoprim Double Strength
Septra
Sandoz Polytrimethoprim
Indication
As a monotherapy, trimethoprim is indicated for the treatment of acute episodes of uncomplicated urinary tract infections caused by susceptible bacteria, including _E. coli._, _K. pneumoniae_, _Enterobacter spp._, _P. mirabilis_, and coagulase-negative _Staphylococcus_ species.[L11893,L11890] In various formulations in combination with [sulfamethoxazole], trimethoprim is indicated for the following infections caused by bacteria with documented susceptibility: urinary tract infections, acute otitis media in pediatric patients (when clinically indicated), acute exacerbations of chronic bronchitis in adults, enteritis caused by susceptible _Shigella_, prophylaxis and treatment of _Pneumocystis jiroveci_ pneumonia, and travelers' diarrhea caused by enterotoxigenic _E. coli_.[L11830,L11863] Trimethoprim is available as an ophthalmic solution in combination with [polymyxin B] for the treatment of acute bacterial conjunctivitis, blepharitis, and blepharoconjunctivitis caused by susceptible bacteria.[L11887]
Drug Info/Drug Targets: DrugBank 3.0: a comprehensive resource for 'omics' research on drugs. Knox C, Law V, Jewison
T, Liu P, Ly S, Frolkis A, Pon A, Banco K, Mak C, Neveu V, Djoumbou Y, Eisner R, Guo AC, Wishart DS.
Nucleic Acids Res. 2011 Jan; 39 (Database issue):D1035-41. | PMID:21059682