TTP

THYMIDINE-5'-TRIPHOSPHATE

Find entries where: TTP

is present as a standalone ligand in 193 entries

as a non-polymer is covalently linked to polymer or other heterogen groups 13 entries

Find related ligands:

Similar Ligands (Stereospecific)

Similar Ligands (Quick Screen)

Toggle Hydrogen Toggle Labels

Chemical Component Summary
Name	THYMIDINE-5'-TRIPHOSPHATE
Identifiers	[(2R,3S,5R)-3-hydroxy-5-(5-methyl-2,4-dioxo-pyrimidin-1-yl)oxolan-2-yl]methyl (hydroxy-phosphonooxy-phosphoryl) hydrogen phosphate
Formula	C₁₀ H₁₇ N₂ O₁₄ P₃
Molecular Weight	482.168
Type	NON-POLYMER
Isomeric SMILES	CC1=CN(C(=O)NC1=O)[C@H]2C[C@@H]([C@H](O2)CO[P@](=O)(O)O[P@@](=O)(O)OP(=O)(O)O)O
InChI	InChI=1S/C10H17N2O14P3/c1-5-3-12(10(15)11-9(5)14)8-2-6(13)7(24-8)4-23-28(19,20)26-29(21,22)25-27(16,17)18/h3,6-8,13H,2,4H2,1H3,(H,19,20)(H,21,22)(H,11,14,15)(H2,16,17,18)/t6-,7+,8+/m0/s1
InChIKey	NHVNXKFIZYSCEB-XLPZGREQSA-N

Chemical Details
Formal Charge	0
Atom Count	46
Chiral Atom Count	5
Bond Count	47
Aromatic Bond Count	0

Drug Info: DrugBank

DrugBank ID	DB02452
Name	Thymidine 5'-triphosphate
Groups	experimental
Synonyms	deoxy-TTP Thymidine 5'-triphosphate Thymidine-5'-triphosphate pppdT 5'-TTP 2'-deoxythymidine triphosphate dTTP
Categories	Deoxyribonucleotides Nucleic Acids, Nucleotides, and Nucleosides Nucleotides Pyrimidine Nucleotides Pyrimidines
CAS number	365-08-2

Drug Targets

Name	Target Sequence	Pharmacological Action
Thymidine kinase, cytosolic	MSCINLPTVLPGSPSKTRGQIQVILGPMFSGKSTELMRRVRRFQIAQYKC...	unknown
Anaerobic ribonucleoside-triphosphate reductase	MTIEKEIEGLIHKTNKDLLNENANKDSRVFPTQRDLMAGIVSKHIAKNMV...	unknown
Thymidylate kinase	MLIAIEGVDGAGKRTLVEKLSGAFRAAGRSVATLAFPRYGQSVAADIAAE...	unknown
Glucose-1-phosphate thymidylyltransferase 2	MKGIILAGGSGTRLHPITRGVSKQLLPIYDKPMIYYPLSVLMLAGIREIL...	unknown
DNA primase/helicase	MDNSHDSDSVFLYHIPCDNCGSSDGNSLFSDGHTFCYVCEKWTAGNEDTK...	unknown
Glucose-1-phosphate thymidylyltransferase	MKTRKGIILAGGSGTRLYPVTMAVSKQLLPIYDKPMIYYPLSTLMLAGIR...	unknown
Thymidine kinase 2, mitochondrial	MLLWPLRGWAARALRCFGPGSRGSPASGPGPRRVQRRAWPPDKEQEKEKK...	unknown
Thymidine kinase	MAKVNAFSKKIGWIELITGPMFAGKTAELIRRLHRLEYADVKYLVFKPKI...	unknown
Ribonucleoside-diphosphate reductase 2 subunit alpha	MATTTPERVMQETMDYHALNAMLNLYDKAGHIQFDKDQQAIDAFFATHVR...	unknown
Glucose-1-phosphate thymidylyltransferase	MKRKGIILAGGSGTRLHPATLAISKQLLPVYDKPMIYYPLSTLMLAGIRE...	unknown
View More

Drug Info/Drug Targets: DrugBank 3.0: a comprehensive resource for 'omics' research on drugs. Knox C, Law V, Jewison T, Liu P, Ly S, Frolkis A, Pon A, Banco K, Mak C, Neveu V, Djoumbou Y, Eisner R, Guo AC, Wishart DS. Nucleic Acids Res. 2011 Jan; 39 (Database issue):D1035-41. | PMID:21059682