Chemical Component Summary

Name3,5-DIIODOTYROSINE
Identifiers(2S)-2-amino-3-(4-hydroxy-3,5-diiodo-phenyl)propanoic acid
FormulaC9 H9 I2 N O3
Molecular Weight432.982
TypeL-PEPTIDE LINKING
Isomeric SMILESc1c(cc(c(c1I)O)I)C[C@@H](C(=O)O)N
InChIInChI=1S/C9H9I2NO3/c10-5-1-4(2-6(11)8(5)13)3-7(12)9(14)15/h1-2,7,13H,3,12H2,(H,14,15)/t7-/m0/s1
InChIKeyNYPYHUZRZVSYKL-ZETCQYMHSA-N

Chemical Details

Formal Charge0
Atom Count24
Chiral Atom Count1
Bond Count24
Aromatic Bond Count6

Drug Info: DrugBank

DrugBank IDDB03374 
Name3,5-Diiodotyrosine
Groups experimental
DescriptionA product from the iodination of MONOIODOTYROSINE. In the biosynthesis of thyroid hormones, diiodotyrosine residues are coupled with other monoiodotyrosine or diiodotyrosine residues to form T4 or T3 thyroid hormones (THYROXINE and TRIIODOTHYRONINE). [PubChem]
Synonyms3,5-Diiodotyrosine
Categories
  • Antithyroid agents
  • Thyroid Products
CAS number300-39-0

Drug Targets

NameTarget SequencePharmacological ActionActions
cAMP-dependent protein kinase inhibitor alphaMTDVETTYADFIASGRTGRRNAIHDILVSSASGNSNELALKLAGLDINKT...unknown
cAMP-dependent protein kinase catalytic subunit alphaMGNAAAAKKGSEQESVKEFLAKAKEDFLKKWESPAQNTAHLDQFERIKTL...unknown
Alpha-amylase G-6MNASYVKKVSLYLLLSFVITLPLFSPTFSINSVDASQGGEQQSFSWDNAT...unknown
Trypsin-1MNPLLILTFVAAALAAPFDDDDKIVGGYNCEENSVPYQVSLNSGYHFCGG...unknown
Nickel-binding periplasmic proteinMLSTLRRTLFALLACASFIVHAAAPDEITTAWPVNVGPLNPHLYTPNQMF...unknown
View More
Drug Info/Drug Targets: DrugBank 3.0: a comprehensive resource for 'omics' research on drugs. Knox C, Law V, Jewison T, Liu P, Ly S, Frolkis A, Pon A, Banco K, Mak C, Neveu V, Djoumbou Y, Eisner R, Guo AC, Wishart DS. Nucleic Acids Res. 2011 Jan; 39 (Database issue):D1035-41. | PMID:21059682

Related Resource References

Resource NameReference
PubChem 7058163, 9305
ChEMBL CHEMBL1236469
ChEBI CHEBI:15768
CCDC/CSD FESTUV