U10

UBIQUINONE-10

Find entries where: U10

is present as a standalone ligand in 201 entries

as a non-polymer is covalently linked to polymer or other heterogen groups 5 entries

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Chemical Component Summary
Name	UBIQUINONE-10
Synonyms	Coenzyme Q10
Identifiers	2-[(2E,6E,10E,14E,18E,22E,26E,30E,34E)-3,7,11,15,19,23,27,31,35,39-decamethyltetraconta-2,6,10,14,18,22,26,30,34,38-decaenyl]-5,6-dimethoxy-3-methyl-cyclohexa-2,5-diene-1,4-dione
Formula	C₅₉ H₉₀ O₄
Molecular Weight	863.343
Type	NON-POLYMER
Isomeric SMILES	CC1=C(C(=O)C(=C(C1=O)OC)OC)C\C=C(/C)\CC\C=C(/C)\CC\C=C(/C)\CC\C=C(/C)\CC\C=C(/C)\CC\C=C(/C)\CC\C=C(/C)\CC\C=C(/C)\CC\C=C(/C)\CCC=C(C)C
InChI	InChI=1S/C59H90O4/c1-44(2)24-15-25-45(3)26-16-27-46(4)28-17-29-47(5)30-18-31-48(6)32-19-33-49(7)34-20-35-50(8)36-21-37-51(9)38-22-39-52(10)40-23-41-53(11)42-43-55-54(12)56(60)58(62-13)59(63-14)57(55)61/h24,26,28,30,32,34,36,38,40,42H,15-23,25,27,29,31,33,35,37,39,41,43H2,1-14H3/b45-26+,46-28+,47-30+,48-32+,49-34+,50-36+,51-38+,52-40+,53-42+
InChIKey	ACTIUHUUMQJHFO-UPTCCGCDSA-N

Chemical Details
Formal Charge	0
Atom Count	153
Chiral Atom Count	0
Bond Count	153
Aromatic Bond Count	0

Drug Info: DrugBank

DrugBank ID	DB09270
Name	Ubidecarenone
Groups	approved investigational nutraceutical
Description	Ubidecarenone, also called coenzyme Q10, is a 1,4-benzoquinone. From its name (Q10), the Q refers to the constitutive quinone group, and 10 is related to the number of isoprenyl subunits in its tail.[A7874] It is a powerful antioxidant, a lipid-soluble and essential cofactor in mitochondrial oxidative phosphorylation.[A31413] The ubidecarenone is the coenzyme destined for mitochondrial enzyme complexes involved in oxidative phosphorylation in the production of ATP. It is fundamental for cells that have a high metabolic demand.[L1062] Ubidecarenone is sold as a dietary supplement and is not FDA approved as a drug - it is not meant to treat, cure or prevent any disease. FDA does not approve this dietary supplements before sold nor regulate the manufacturing process.[L1063]
Synonyms	Ubidecarenone CoQ10 Coenzyme q10, (2z)- Ubiquinone Coenzyme Q10 Vitamin Q10 Coenzyme Q-10
Brand Names	Protect Cardio AF Coenzyme Q10 Cap 15mg Now Coq10 100 mg Co-q10 30mg (ubiquinone) Formula Statin Support Coenzyme Q-10 Coenzyme Q10 With Hawthorn Extract and Citrus Bioflavonoids Mebolic Q-gel Forte Coenzyme Q10 Co-Q 10 Capsules 50 mg Coenzyme Q10 Cap 30mg tensioSAN Biomed Co Q 10 Ubiquinone Capsules 20mg Usana Optimizer Coquinone Coenzyme Q-10 Capsules Co-enzyme Q10 Cap 30mg Coenzyme Q10 50mg Lexazin Coq-10 Co-q10 M.R.B. 100mg and Vitamin E N.E.U. Complex Acti-ubiquinone 50 Cap 50mg Coenzyme Q10 30mg VitaXyme Daily Supplement Packs Co-enzyme Q10 60 mg Nutra-Z Biogard Ubiquinone Cap 30mg Dayavite Folic-K Formula B Coquinone Coenzyme Q-10 Capsules Methazel Co-q10 30mg Q-10 Plus Co-q10 Cap 30mg Protect Plus SO 60 CoQ10 200mg Neutral C + Coenzyme Q10 - Cap Coenzyme Co Q10 Cap 10mg N.U.T. Complex B.E.T. Complex Co-enzyme-q10 Tab Nicadan ZX Zyvit Coenzyme Q10 60mg Capsules IQQU Acne Serum Coenzyme Q10 - Capsule 30 mg Medi-10 Watkins Coq10 Xyzbac Zavitrol Folika-V Mebolex Co-enzyme Q10 50mg Capsules Vitazyme Co-q10 - Cap 60mg Coenzyme Q10 100mg Coenzyme Q10 60mg L.I.P. Complex Neutral C + Coenzyme Q10 Plus Vitamins & Minerals Coenzyme Q10 + Co-enzyme Q10 30mg Capsules Xyzbac G Coenzyme Q10 100 mg Q-gel Coenzyme Q10 Coenzyme Q10 Isotonix Vitamin and Mineral Supplement Formula O.C. PreQue 10 Coenzyme Q10 30 mg Thera Q Plus Genicin Vita-Q Cellsparc 360 Dyzbac Extra 11 Tru-sorb Coq10 Co-q10 60 Mg Capsules Co-q10 M.R.B. 60mg Co-enzyme Q10 60mg Capsules Formula Dpr Vitamin E and Coq10 Nutri-chem Coenzyme Q10 20mg Rocky Mountain Co Q 10 Cap 25mg Qmelt Coen.q10w.vit.c and E Beta-car.se Cu Zn Mn Coq10 Coenzyme Q10 - 10mg (ubiquinone) Folica BE Co-enzyme Q-10 Coenzyme Q-10 - 30 mg Coenzyme Q10 (60 Mg) Folica-V Vita-Rx Diabetic Vitamin Co Q 10 - 50mg Cap PROTECT IRON Liquid Amladex Co-Q-10 Capsules 30mg Coenzyme Q10 80mg Omnivex Coenzyme Q10 - 30mg (ubiquinone) Co-q10 and Vitamin E Coenzyme Q10 Tab 10mg Taliment Coenzyme Q10 50 mg Omniquin Super 7 Vitamin and Mineral Supplement C.V. Formula Oveeza Coenzyme Q10 Ubiquinone 60mg - Cap Coenzyme Q-10 60 mg Coq10 With E400 Iu Q-10 Extra -cap Co-enzyme Q10 100mg Coenzyme Co Q10 Cap 30mg Fibrik Biosculpt Formula S.E. Formula Cp Cap Co-enzyme Q-10 Capsules Cell Tech Coenzyme Q10 - Cap 30mg Coenzyme Q10 Coenzyme-q10 M.R.B. Coenzyme Q10 60mg Cap Corvite Free Co-q10 (ubiquinone)
Indication	The diet supplements containing ubidecarenone are indicated, as stated in the product label, to assist individuals with cardiovascular complaints including congestive heart failure and systolic hypertension. In the product, ubidecarenone is used to increase the cardiac input as well as for the prevention of several other diseases like Parkinson, fibromyalgia, migraine, periodontal disease and diabetes, based on preclinical studies.[L1064] It is important to highlight that these products are not FDA approved and it is recommended to use under discretion.
Categories	Agents Causing Muscle Toxicity Benzoquinones Cardiac Therapy Coenzymes Diet, Food, and Nutrition Electron Transport Chain Complex Proteins Enzymes and Coenzymes Food Hypoglycemia-Associated Agents Micronutrients Other Nutritional Agents P-glycoprotein substrates Physiological Phenomena Quinones Ubiquinone Vitamins
ATC-Code	C01EB09
CAS number	303-98-0

Drug Targets

Name	Target Sequence	Pharmacological Action	Actions
NADH dehydrogenase [ubiquinone] flavoprotein 3, mitochondrial	MAAPCLLRQGRAGALKTMLQEAQVFRGLASTVSLSAESGKSEKGQPQNSK...	unknown	cofactor
Succinate dehydrogenase [ubiquinone] flavoprotein subunit, mitochondrial	MSGVRGLSRLLSARRLALAKAWPTVLQTGTRGFHFTVDGNKRASAKVSDS...	unknown	cofactor
3-hydroxy-3-methylglutaryl-coenzyme A reductase	MLSRLFRMHGLFVASHPWEVIVGTVTLTICMMSMNMFTGNNKICGWNYEC...	unknown	substrate
Low-density lipoprotein receptor	MGPWGWKLRWTVALLLAAAGTAVGDRCERNEFQCQDGKCISYKWVCDGSA...	unknown	substrate
Very low-density lipoprotein receptor	MGTSALWALWLLLALCWAPRESGATGTGRKAKCEPSQFQCTNGRCITLLW...	unknown	substrate
P-glycoprotein 1	MDLEGDRNGGAKKKNFFKLNNKSEKDKKEKKPTVSVFSMFRYSNWLDKLY...	unknown	substrate
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Drug Info/Drug Targets: DrugBank 3.0: a comprehensive resource for 'omics' research on drugs. Knox C, Law V, Jewison T, Liu P, Ly S, Frolkis A, Pon A, Banco K, Mak C, Neveu V, Djoumbou Y, Eisner R, Guo AC, Wishart DS. Nucleic Acids Res. 2011 Jan; 39 (Database issue):D1035-41. | PMID:21059682