U10

UBIQUINONE-10

Find entries where: U10

is present as a standalone ligand in 201 entries

as a non-polymer is covalently linked to polymer or other heterogen groups 5 entries

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Chemical Component Summary
Name	UBIQUINONE-10
Synonyms	Coenzyme Q10
Identifiers	2-[(2E,6E,10E,14E,18E,22E,26E,30E,34E)-3,7,11,15,19,23,27,31,35,39-decamethyltetraconta-2,6,10,14,18,22,26,30,34,38-decaenyl]-5,6-dimethoxy-3-methyl-cyclohexa-2,5-diene-1,4-dione
Formula	C₅₉ H₉₀ O₄
Molecular Weight	863.343
Type	NON-POLYMER
Isomeric SMILES	CC1=C(C(=O)C(=C(C1=O)OC)OC)C\C=C(/C)\CC\C=C(/C)\CC\C=C(/C)\CC\C=C(/C)\CC\C=C(/C)\CC\C=C(/C)\CC\C=C(/C)\CC\C=C(/C)\CC\C=C(/C)\CCC=C(C)C
InChI	InChI=1S/C59H90O4/c1-44(2)24-15-25-45(3)26-16-27-46(4)28-17-29-47(5)30-18-31-48(6)32-19-33-49(7)34-20-35-50(8)36-21-37-51(9)38-22-39-52(10)40-23-41-53(11)42-43-55-54(12)56(60)58(62-13)59(63-14)57(55)61/h24,26,28,30,32,34,36,38,40,42H,15-23,25,27,29,31,33,35,37,39,41,43H2,1-14H3/b45-26+,46-28+,47-30+,48-32+,49-34+,50-36+,51-38+,52-40+,53-42+
InChIKey	ACTIUHUUMQJHFO-UPTCCGCDSA-N

Chemical Details
Formal Charge	0
Atom Count	153
Chiral Atom Count	0
Bond Count	153
Aromatic Bond Count	0

Drug Info: DrugBank

DrugBank ID	DB09270
Name	Ubidecarenone
Groups	approved investigational nutraceutical
Description	Ubidecarenone, also called coenzyme Q10, is a 1,4-benzoquinone. From its name (Q10), the Q refers to the constitutive quinone group, and 10 is related to the number of isoprenyl subunits in its tail.[A7874] It is a powerful antioxidant, a lipid-soluble and essential cofactor in mitochondrial oxidative phosphorylation.[A31413] The ubidecarenone is the coenzyme destined for mitochondrial enzyme complexes involved in oxidative phosphorylation in the production of ATP. It is fundamental for cells that have a high metabolic demand.[L1062] Ubidecarenone is sold as a dietary supplement and is not FDA approved as a drug - it is not meant to treat, cure or prevent any disease. FDA does not approve this dietary supplements before sold nor regulate the manufacturing process.[L1063]
Synonyms	Coenzyme q10, (2z)- Ubiquinone Coenzyme Q10 Ubidecarenone Vitamin Q10 Coenzyme Q-10 CoQ10
Brand Names	Neutral C + Coenzyme Q10 - Cap Biogard Ubiquinone Cap 30mg Rocky Mountain Co Q 10 Cap 25mg Fibrik Dayavite Vitamin E and Coq10 Xyzbac G Oveeza Co-q10 M.R.B. 60mg Vitazyme Co-enzyme Q10 60 mg Formula B Co-enzyme Q10 100mg Coenzyme Q10 Isotonix Vitamin and Mineral Supplement CoQ10 200mg Medi-10 Super 7 Vitamin and Mineral Supplement Coenzyme Q10 80mg Coenzyme Q10 + Formula Dpr Coenzyme Q10 50 mg Folica BE Coenzyme Co Q10 Cap 30mg Co-q10 30mg B.E.T. Complex Q-gel Coenzyme Q10 Coq10 With E400 Iu N.E.U. Complex Coenzyme Q-10 Co-enzyme Q10 30mg Capsules Genicin Vita-Q Cellsparc 360 Coenzyme Q10 Tab 10mg Daily Supplement Packs C.V. Formula N.U.T. Complex Coenzyme Q10 Cap 30mg Formula O.C. Mebolex Coenzyme Q10 30 mg Coenzyme Co Q10 Cap 10mg Usana Optimizer Coquinone Coenzyme Q-10 Capsules Watkins Coq10 Protect Plus SO 60 Q-10 Plus Coenzyme Q10 Coenzyme Q10 - 30mg (ubiquinone) Coq10 Coenzyme Q10 60mg Capsules Cell Tech Coenzyme Q10 - Cap 30mg Co-enzyme Q10 50mg Capsules Co-enzyme-q10 Tab Lexazin Q-10 Extra -cap Coenzyme Q10 Cap 15mg Nicadan ZX Coenzyme Q10 (60 Mg) Coenzyme Q10 60mg Co-enzyme Q10 Cap 30mg Folic-K Co-q10 and Vitamin E L.I.P. Complex Coenzyme Q10 - Capsule 30 mg Co-Q 10 Capsules 50 mg Folica-V Q-gel Forte Coenzyme Q10 Acti-ubiquinone 50 Cap 50mg Coenzyme Q10 100 mg Coenzyme Q-10 - 30 mg Protect Cardio AF Zyvit Amladex Coenzyme Q10 30mg Folika-V VitaXyme Formula S.E. Tru-sorb Coq10 PreQue 10 Thera Q Plus Dyzbac Taliment Nutri-chem Coenzyme Q10 20mg Ubiquinone Capsules 20mg Coenzyme Q10 With Hawthorn Extract and Citrus Bioflavonoids IQQU Acne Serum Coenzyme Q10 Ubiquinone 60mg - Cap Omniquin Coq-10 Omnivex Qmelt Biosculpt Co-enzyme Q-10 Capsules Methazel Biomed Co Q 10 PROTECT IRON Liquid Formula Statin Support tensioSAN Coenzyme Q-10 60 mg Co-Q-10 Capsules 30mg Coen.q10w.vit.c and E Beta-car.se Cu Zn Mn Neutral C + Coenzyme Q10 Plus Vitamins & Minerals Coquinone Coenzyme Q-10 Capsules Co-q10 M.R.B. 100mg and Vitamin E Coenzyme Q10 50mg Co-q10 30mg (ubiquinone) Formula Cp Cap Zavitrol Co-q10 (ubiquinone) Co-q10 60 Mg Capsules Nutra-Z Coenzyme Q10 100mg Vita-Rx Diabetic Vitamin Co-enzyme Q-10 Now Coq10 100 mg Coenzyme Q10 60mg Cap Co-enzyme Q10 60mg Capsules Coenzyme Q10 - 10mg (ubiquinone) Xyzbac Co Q 10 - 50mg Cap Extra 11 Co-q10 - Cap 60mg Co-q10 Cap 30mg Coenzyme-q10 M.R.B. Corvite Free Mebolic
Indication	The diet supplements containing ubidecarenone are indicated, as stated in the product label, to assist individuals with cardiovascular complaints including congestive heart failure and systolic hypertension. In the product, ubidecarenone is used to increase the cardiac input as well as for the prevention of several other diseases like Parkinson, fibromyalgia, migraine, periodontal disease and diabetes, based on preclinical studies.[L1064] It is important to highlight that these products are not FDA approved and it is recommended to use under discretion.
Categories	Agents Causing Muscle Toxicity Benzoquinones Cardiac Therapy Coenzymes Diet, Food, and Nutrition Electron Transport Chain Complex Proteins Enzymes and Coenzymes Food Hypoglycemia-Associated Agents Micronutrients Other Nutritional Agents P-glycoprotein substrates Physiological Phenomena Quinones Ubiquinone Vitamins
ATC-Code	C01EB09
CAS number	303-98-0

Drug Targets

Name	Target Sequence	Pharmacological Action	Actions
NADH dehydrogenase [ubiquinone] flavoprotein 3, mitochondrial	MAAPCLLRQGRAGALKTMLQEAQVFRGLASTVSLSAESGKSEKGQPQNSK...	unknown	cofactor
Succinate dehydrogenase [ubiquinone] flavoprotein subunit, mitochondrial	MSGVRGLSRLLSARRLALAKAWPTVLQTGTRGFHFTVDGNKRASAKVSDS...	unknown	cofactor
3-hydroxy-3-methylglutaryl-coenzyme A reductase	MLSRLFRMHGLFVASHPWEVIVGTVTLTICMMSMNMFTGNNKICGWNYEC...	unknown	substrate
Low-density lipoprotein receptor	MGPWGWKLRWTVALLLAAAGTAVGDRCERNEFQCQDGKCISYKWVCDGSA...	unknown	substrate
Very low-density lipoprotein receptor	MGTSALWALWLLLALCWAPRESGATGTGRKAKCEPSQFQCTNGRCITLLW...	unknown	substrate
P-glycoprotein 1	MDLEGDRNGGAKKKNFFKLNNKSEKDKKEKKPTVSVFSMFRYSNWLDKLY...	unknown	substrate
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Drug Info/Drug Targets: DrugBank 3.0: a comprehensive resource for 'omics' research on drugs. Knox C, Law V, Jewison T, Liu P, Ly S, Frolkis A, Pon A, Banco K, Mak C, Neveu V, Djoumbou Y, Eisner R, Guo AC, Wishart DS. Nucleic Acids Res. 2011 Jan; 39 (Database issue):D1035-41. | PMID:21059682