Pyridoxine is the 4-methanol form of vitamin B6, an important water-soluble vitamin that is naturally present in many foods. As its classification as a vitamin implies, Vitamin B6 (and pyridoxine) are essential nutrients required for normal functioning of many biological systems within the body. While many plants and microorganisms are able to synthesize pyridoxine through endogenous biological processes, animals must obtain it through their diet. More specifically, pyridoxine is converted to pyridoxal 5-phosphate in the body, which is an important coenzyme for synthesis of amino acids, neurotransmitters (serotonin, norepinephrine), sphingolipids, and aminolevulinic acid. It's important to note that Vitamin B6 is the collective term for a group of three related compounds, pyridoxine, pyridoxal, and pyridoxamine, and their phosphorylated derivatives, pyridoxine 5'-phosphate, pyridoxal 5'-phosphate and pyridoxamine 5'-phosphate. Although all six of these compounds should technically be referred to as vitamin B6, the term vitamin B6 is commonly used interchangeably with just one of them, pyridoxine [A32836]. Vitamin B6, principally in its biologically active coenzyme form pyridoxal 5'-phosphate, is involved in a wide range of biochemical reactions, including the metabolism of amino acids and glycogen, the synthesis of nucleic acids, hemogloblin, sphingomyelin and other sphingolipids, and the synthesis of the neurotransmitters serotonin, dopamine, norepinephrine and gamma-aminobutyric acid (GABA) [A32837]. Pyridoxine is used medically for the treatment of vitamin B6 deficiency and for the prophylaxis of isoniazid-induced peripheral neuropathy (due to [DB00951]'s mechanism of action which competitively inhibits the action of pyridoxine in the above-mentioned metabolic functions). It is also used in combination with [DB00366] (as the commercially available product Diclectin) for the treatment of nausea and vomiting in pregnancy.
Synonyms
Pyridoxol
3-hydroxy-4,5-dimethylol-α-picoline
3-hydroxy-4,5-bis(hydroxymethyl)-2-methylpyridine
Vitamin B6
Pyridoxinum
Pyridoxine
2-methyl-3-hydroxy-4,5-dihydroxymethylpyridine
5-hydroxy-6-methyl-3,4-pyridinedimethanol
Piridoxina
Pyridoxine hydrochloride
Brand Names
ProFola
Mini-B Tab
Hemarexin Tab
PR Natal 400 ec
Multi Vitamin and Mineral vitamin
O-Cal FA multivitamin
Balanced B-complex Vit + Vit C&e Tab
Isotonix Multitech Vitamin Mineral Supplemen
Kid's Choice Children's Chewable Vitamins - Tab
Children's Chew Multi & Min Tab
Stress Ctr Srt
Cell Power Boosting Essence
Foliflex
Children's Chewable Multivitamins and Minerals
B Compound 50mg Tab
Perioe lucky fresh - cavity care
B6-niacinamide Tab
V-Natal
Multi-phyto Capsules
Magnum-75 Vitamin and Mineral Supplement
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Floriva Plus
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Somavit Brand Vitamins and Minerals Complex
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Prenate Pixie
Vita-B
Vp-zel
Mycelized Childrens Multi-vitamin Liq
ahoSAN
Dalivit
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Genicin Vita-S
Mvc 9 Plus 3 Inj
Prefera OB plus DHA
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Liqui Vita
Multivitamins
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Virt-Vite
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Cavan X
Multivitamin Drops with Fluoride
Multi Nt-OX
Timed Release B-complex 50
Reno Caps
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Multi Vitamin - Mineral
Prenatal and Post Partum Supplement
Vitamin B6 100mg
24 Multivitamins + Minerals
Kanga-V Multivitamins & Minerals
Taron-prex Prenatal
Vitamin B6 Capsules 3.5mg
Obstetrix DHA Combo Pack
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FolaGent DHA
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healthy mamaBE WELL ROUNDED BE WELL ROUNDED
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Vitamine B6 100mg
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Stress B-complex Plus Iron With Vitamins C&e
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Divista
Ez-flex
Longevit-E - Capsule
Prenatal Vitamin No 53 Iron Fum Folic Acid Docusate CA DHA
Vitamin B6 Tablets 250mg
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MultiVitamin, Iron and Fluoride Drops
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Onccor
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Vitamin B-6 200mg
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Vitramyn
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Dr.Pauhls TOOTHPAST E LIME MANDARIN FLAVOR
Nicadan
PreFol-DHA
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Marnatal F
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B6 250 Caplet 250mg
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Swical-energy 3e Age
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Kenwood Liquid Supplement
Century Complete
Super-pote Vitamin Supplement
PR Natal 400
Venexa
Multivitamines Plus Fer Pour Enfants (chewable Tablets)
Pro Hers Vanilla
Vitamin B6 Tab 25mg
Pyridoxen Tab 50mg
Natelle One
Pnv-VP-U
PreNatal 19
Stress B Complex With C, E & Iron
Prenate Essential
Formula B
B Stress C + Iron & Vite
For Kids Only Chewable Multivitamins - Tab
Multivitamins and Minerals With Betacarotene Tablets
New Chapter's D'adamo 4 Your Type Multiple for Type O
Menatrol
Vitamin B Complex + C 600mg Tab
Tri Adrenopan
Z Bec Tab
Complete-RF Prenatal
Multiple Vitamins - Tablet
Stress Tab With Zinc, Copper and Vitamin E
Flintstones W Extra C Tab
Apo-doxylamine/b6
Citranatal B-calm
Daily-Vite
R.E.S. Complex
Women's Change Formula
Folcaps
Cavan One
Tandem OB
Nata Komplete
Poly-Vi-Sol
Premium Prenatal
Folcaps Care One
Trinatal GT
Dialyvite 3000
Extra-Virt Plus DHA
Prena1 Chew
Hi Potency Stress B Tension With C
Chewable Multivitamins
Diclectin
Alertonic
Phytovim Cap
Prenatal Vitamin and Mineral Supplement -tab
Se-Natal 19 Chewable
Pnv-dha
Multi 1000
Acetabolan III Vitamin and Mineral Supplement
P.R.O. Complex
Adeks Tablets
Beminal Fortis Elx
Dialyvite with Zinc
Maxum Multi-vite
Gynedyn Tab
PreferaOB
M.V.I.-12
Liqui Infant Vitamins
M-Natal Plus
N.E.U. Complex
Childrens Chewable Vitamins
Super B Compound W 500mg Vit C
PreNatal Vitamins Plus
B-100 Caps
Q.T. #4 Vitamin and Mineral Dietary Supplement
Vitamin B Complex W C Tab
Prenatal, DHA
PRENATE Restore
Vasculine
Childrens Chewable Tab
Vitamine B6 Tab 25mg USP Chewable
Tricare Prenatal DHA One Rx Multivitamin
Iron Polysaccharides Folic Acid DHA
Prenatal Vi-min
Multi Rol
Vit B Complex Ctr
Kanga-kid Vitamins & Iron
Allbee With C 550 Cap
Thrivite 19
WesNate DHA
Everyday Multiple Vitamins With Iron
Formula F L W
B C Antistress Cap
Stress Tablets
B Complex W C and B12 Inj
B6 Tab 100mg
Adult Formula 50+
Osteo-force
Prenatal Supplement - Tab
Iberet 500
Multivitamin & Multimineral
Vitranol
Acv
Pregvit
Balanced B-50 B-complex Vitamins, Timed Rele
Multi-Vit with Fluoride and Iron
Zoo Chews
Multiple Vitamins & Minerals Tablets
Udamin Sp
Bugs Bunny Chew Multi Vit Plus Iron
Virt-Pn DHA
NephPlex Rx
Revitalize Multi-vitamin and Mineral Complex
Acetabolan-II Vitamin and Mineral Supplement
Vita B Complex Tab
Cal M Tab
Multivit-liq
Spd Tab
N.U.T. Complex
Multivitamines Pour Enfants (chewable Tablets)
Renal Caps Dialysis/Stress Vitamin Supplement
Ellis Tonic
Lipotropic Ctr
Kindervites
WesTab Plus
Super Multi
Lustime Unicorn
Multitabs
Virt-PN
Vontee
Vitamine B6 Tab 250mg
Vit B Complex Plus Vit C 550mg
Taron-C DHA
Children's Chewable Tab
L-Methyl MC
Multicaps
Multiple Vitamin Plus Minerals Tab
Complete One-A-day - Tab
L-Methyl-MC
Prenatal
Hi Potency Klb6 Tab 17mg
WesCap-C-DHA
Multivitamins and Minerals for Young Women
Tar-end
Deriton
Relnate DHA
Supravite Stress Avec Vit E Et Fer
Vitamin B Complex Tab
Vitafer - Liq
Kids Stuff With Iron Tablets
Nephrocaps
MultiVitamin Drops with Fluoride and Iron
Body Rox
Ultimate Tab
Polymine Avec Zinc Et Cuivre
Paramettes Adults
Multivitamins and Minerals - Complete
Swiss One
Multi-12/k1 Pediatric
Se-Care Chewable
Croq-vit Pour Enfants
B Plus C 300mg Timed Release
Livita Children
Virt-PN Plus
Vitafol One
Adeks - Dps
Men's Multi Master Formula
Multi Tabs
Provida DHA
Multi-vitamin Dietary Supplement
L.C. Supplement
Neo-bex
Vitrexate
Tricare Prenatal DHA One With Folate
Orifer F
Prenatal Vitamin and Mineral Supplement Tab
Multi-Vitamin with Fluoride
HemeNatal OB plus DHA
Olympian Multi Vit Plus Minerals Tab
Dr. AVi MULTIVITAMIN with Zinc, Real Ginger, Lemon and Lemongrass
Childrens Chewable Multiple Vitamins
Materna-tab
Vitranol Fe
Children's Chewable Multiple Vit.plus Iron
Vitamin B6 50mg
VP CH Plus
Poly-VI-flor
Children's Chewable Multiple Vitamins With Extra Vitamin C (chewable Tablets)
Vitamin B6
Prenatal Vitamin and Mineral Supplement
M.V.I. Paediatric
Neo Bex Elixir
Swiss One Multi Vit & Chel Min Tab
Nrg Plus Liq
Vitafol
Focalgin B
Dialyvite
Vitafol Caplet
Super Vita Vim Multivitamins and Minerals
Maintain Multiple Vitamin & Minerals
Mangadyn
Min-chex Cap
Bio-fen
VP CH Ultra
E.S.T. Complex
Formula Hh
Prenatal Vitamins and Minerals Tablets
Cavan Prenatal
Formula Est'ro Tab Support
Pyridoxine HCl Tab 50mg
TL-Select
Children's Chewable Multiple Vitamins With Iron Tablets (chewable Tablets)
Cavan Folate DHA
Niva-Fol
Neonatal Plus Vitamin
Vitamin B-6 Tab 200mg
Vitamin B6 Cap 250mg
Carbaway
Somarexin and C 1000
TriStart DHA
Glyco-aide Tab
Prena1 Plus
Surbex-500 With Iron
Quflora Pediatric Drops
Dexifol
Multiple Vitamins Plus Iron Tab
Cavan Alpha
Super Daily No 2
Men's 50+
PreNexa
C. Vit-min Formula
Supravite C 1000
High Potency Multivitamins & Minerals Caplets
Se-Plete DHA
Super Charged Energy
Viva Kids - Tab
Multitam
EC + Complex
Davimet
TriStart FREE
Advanced 2000 Capsules
Magnesium 50mg With Vitamin B6 Tab
B6 25 Tab 25mg
Prenatal Plus Vitamins
Chewable Multiple Vitamins Tab
Vitamin B Compound W C Tab 500mg
Se-Tan DHA
Hi Potency Multi Tab
Prenate Mini
Stress Formula Tab
Feminex 300 Tab
Mega-vim 75 With Beta-carotene - Tablets
TL-Folate
Klb6 Tablets 17mg
Formula O.C.
NovaFerrum Multivitamin with Iron Pediatric Drops
Vitamune
Niva-Plus
Vitaflex Dietary Suplement
Pnv Ob DHA
Multipack II
Ventrixyl Fe
Orange Flavored Crystal Chews Tab
Stress Complex 600 Avec Vit E Cuivre Zinc
Children's Multivitamins
Avon Vitadvance Multi-kids Complete
Lgb-dtx Tab 10mg
Docosavit
Bal-Care DHA
Reebok
CitraNatal DHA
Folica BE
Nestabs ONE
Chew.multiple Vits.with Extra C for Children
Vitamin B + C Cap
Lipo-B-C Tab
Twin Ultra Liquid Orange Flavor
Escavite Lq
Lipotrope-plus B6 Tab
Homosistrox Capsules
tensioSAN
Lorid
Vyqua
Multi B
Vitamines Pour Bebes Et Enfants
Vitaphil 90 DHA
TriStart ONE
CitraNatal B-Calm
Tricare Prenatal
Multiple Vitamins and Minerals
RE Nata
Lutime
Animi-3 with Vitamin D
Vitamin B-6 50 Mg Tablet
Folcal DHA
Mega Capsules
Vinacal
Vitamin B6 100mg Caplet
Multiple Vitamins and Minerals Capsules
Children's Vitamins Chewable
AzesChew
American Plus Energy & Vitamin Drink
Calcium Folic Acid Plus D Chewable
Timed Release Vita-vim Srt
Trinatal Rx 1
Sun-rype Vitaburst
Wellness Formula
MultiVitamin with Fluoride
FolaMax
Hi Potency Balanced B-100 Complex - Tab
Neonatal Vitamin
Prenatabs FA
Twin Ultra Liquid Fruit Punch Flavor
B Complex Plus C 300mg Tab
Venexa FE
Super Stress Mega B Plus 1000mg Vit C Tab
TriAdvance
B-6 Caps 250mg
Toni Com Liq
Formula Im-vitamins and Minerals Tab
Vc II
Prenate AM
Virt-Tabs
Feminique W Iron and Calcium Tab
Se-Natal
Card-floe II Tab
Men's
Virt-Vite Plus
Pregnancy Multivitamin
Vitamin B-6 100mg
Vita B + C 500 Tab
Carbassist Tablets
Fortamines 10 Capsules
Vitalife - Capsule
B-plex 100
Balanced B-50 Complex
Prost-10 Vitamin and Mineral Supplement
Children Choice Multivitamin W Iron Chew Tab
CitraNatal Essence
B Complex With C 300mg Tab
Vitogen B Stress C Vit E Zinc & Cop
Childrens Chewable Multiple Vitamins Plus Fe
Florafol FE Pediatric 0.25 mg/mL Multivitamin and Fluoride Liquid Drops
Ultra Enerforce
Multi-Vitamin With Fluoride
Integra Plus
Chewable Multiple Vit Plus Iron for Children
Viva CT Prenatal
Vit B6 Ctr Srt 100mg
Stress Formula
B6 Cap 100mg
C-apnto-B6 Vitamins W Magnesium Tab
Fem - F.S. Formula
Mega Vitaminerals
Multivitamin with 1.0 mg Fluoride
RediChew
B Complex W C Forte Cap
Flintstones Multiple Vitamins
Zeldana
Childrens Chewable Vitamin Tab
Beminal W C Fortis Inj
Multi-12 Pediatric
Folic-K
Dermagran Moisturizing Spray
Osteo Formula
Triveen-Duo DHA
Soothe
VP-Vite Rx
Niaacinamide Azelaic AC TURMER FA B6 Zinc Ox Copper
Animal Shapes w/Iron Chewtabs
Carthaphy Cap
Tini-cal Ampoules
Pnv-OB-dha
Fem - Pmt
Flintstones Multiple Vitamins Tab
Prim - Royal P.M.T.
Vitamin B6 Tab 100mg USP
Multiple Vitamins With Iron
PNV-First
Nephron FA
Multiple Vitamins
Leritone Junior
Vitamin B6 50mg Tab
Childrens Chewable Multivitamins
Derma-force
Davimet with Fluoride
Strovite One Caplets
Teva-doxylamine/pyridoxine Dr
PROTECT IRON Liquid
One A Day Tab
Formula A.L.- Tab 17mg
Tendera-OB
PMS-doxylamine-pyridoxine
One A Day Advance Fem
VirtPrex
Evc - Liq
Solaray
Zinc Plus Vitamins C & B6 Lozenges
Osteo Factors
B6 400mg Ctr Tab
Pregvit Folic 4
Virt-Vite Forte
Formula Lf
Vena-Bal DHA
Focalgin 90 DHA
Stress Formula Multivitamin Tablets USP
vitaMedMD Rx Plus
Tricare Prenatal Quick Dissolve
Fem Time Tab
Lip - Fac Formula
Spark Cap
Children's Chewable Multi-vitamin
Quflora FE Pediatric Drops
PreferaOB plus DHA
Indication
Pyridoxine is indicated for the treatment of vitamin B6 deficiency and for the prophylaxis of [DB00951]-induced peripheral neuropathy. It is also approved by Health Canada for the treatment of nausea and vomiting in pregnancy in a combination product with [DB00366] (as the commercially available product Diclectin).
Drug Info/Drug Targets: DrugBank 3.0: a comprehensive resource for 'omics' research on drugs. Knox C, Law V, Jewison
T, Liu P, Ly S, Frolkis A, Pon A, Banco K, Mak C, Neveu V, Djoumbou Y, Eisner R, Guo AC, Wishart DS.
Nucleic Acids Res. 2011 Jan; 39 (Database issue):D1035-41. | PMID:21059682