UFP

5-FLUORO-2'-DEOXYURIDINE-5'-MONOPHOSPHATE


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Chemical Component Summary

Name5-FLUORO-2'-DEOXYURIDINE-5'-MONOPHOSPHATE
Identifiers[(2R,3S,5R)-5-(5-fluoro-2,4-dioxo-pyrimidin-1-yl)-3-hydroxy-oxolan-2-yl]methyl dihydrogen phosphate
FormulaC9 H12 F N2 O8 P
Molecular Weight326.172
TypeDNA LINKING
Isomeric SMILESC1[C@@H]([C@H](O[C@H]1N2C=C(C(=O)NC2=O)F)COP(=O)(O)O)O
InChIInChI=1S/C9H12FN2O8P/c10-4-2-12(9(15)11-8(4)14)7-1-5(13)6(20-7)3-19-21(16,17)18/h2,5-7,13H,1,3H2,(H,11,14,15)(H2,16,17,18)/t5-,6+,7+/m0/s1
InChIKeyHFEKDTCAMMOLQP-RRKCRQDMSA-N

Chemical Details

Formal Charge0
Atom Count33
Chiral Atom Count3
Bond Count34
Aromatic Bond Count0

Drug Info: DrugBank

DrugBank IDDB03761 
Name5-fluoro-2'-deoxyuridine-5'-monophosphate
Groups experimental
Synonyms
  • 5-fluorodeoxyuridine monophosphate
  • F-dUMP
  • 5FdUMP
  • 5-fluoro-2'-deoxyuridine-5'-monophosphate
Categories
  • Deoxyribonucleotides
  • Deoxyuracil Nucleotides
  • Nucleic Acids, Nucleotides, and Nucleosides
  • Nucleotides
  • Pyrimidine Nucleotides
CAS number134-46-3

Drug Targets

NameTarget SequencePharmacological ActionActions
Thymidylate synthaseMKQYLELMQKVLDEGTQKNDRTGTGTLSIFGHQMRFNLQDGFPLVTTKRC...unknown
Thymidylate synthaseMLEQPYLDLAKKVLDEGHFKPDRTHTGTYSIFGHQMRFDLSKGFPLLTTK...unknown
Thymidylate synthase ThyXMKIDILDKGFVELVDVMGNDLSAVRAARVSFDMGLKDEERDRHLIEYLMK...unknown
Thymidylate synthase 1MTQFDKQYNSIIKDIINNGISDEEFDVRTKWDSDGTPAHTLSVISKQMRF...unknown
Drug Info/Drug Targets: DrugBank 3.0: a comprehensive resource for 'omics' research on drugs. Knox C, Law V, Jewison T, Liu P, Ly S, Frolkis A, Pon A, Banco K, Mak C, Neveu V, Djoumbou Y, Eisner R, Guo AC, Wishart DS. Nucleic Acids Res. 2011 Jan; 39 (Database issue):D1035-41. | PMID:21059682

Related Resource References

Resource NameReference
Pharos CHEMBL886
PubChem 8642
ChEMBL CHEMBL886
ChEBI CHEBI:2129