UN9

N-[(1-CHLORO-4-HYDROXYISOQUINOLIN-3-YL)CARBONYL]GLYCINE



Chemical Component Summary

NameN-[(1-CHLORO-4-HYDROXYISOQUINOLIN-3-YL)CARBONYL]GLYCINE
Identifiers2-[(1-chloro-4-hydroxy-isoquinolin-3-yl)carbonylamino]ethanoic acid
FormulaC12 H9 Cl N2 O4
Molecular Weight280.664
TypeNON-POLYMER
Isomeric SMILESc1ccc2c(c1)c(c(nc2Cl)C(=O)NCC(=O)O)O
InChIInChI=1S/C12H9ClN2O4/c13-11-7-4-2-1-3-6(7)10(18)9(15-11)12(19)14-5-8(16)17/h1-4,18H,5H2,(H,14,19)(H,16,17)
InChIKeyOUQVKRKGTAUJQA-UHFFFAOYSA-N

Chemical Details

Formal Charge0
Atom Count28
Chiral Atom Count0
Bond Count29
Aromatic Bond Count11

Drug Info: DrugBank

DrugBank IDDB08687 
NameFG-2216
Groups investigational
DescriptionA orally active prolyl-hydroxylase inhibitor which can stabilize hypoxia-inducible transcription factor independent of oxygen availability. [A14422]
Synonyms
  • FG-2216
  • 1-Chloro-N- (hydroxyformylmethyl-4-hydroxyisoquinoline-3-carboxamide
  • (((1-Chloro-4-hydroxyisoquinolin-3-yl)carbonyl)amino)acetic acid
  • 1-Chloro-N-(hydroxyformylmethyl-4-hydroxyisoquinoline-3-carboxamide
IndicationInvestigated for use/treatment in anemia and kidney disease.
CAS number223387-75-5

Drug Targets

NameTarget SequencePharmacological ActionActions
Egl nine homolog 1MANDSGGPGGPSPSERDRQYCELCGKMENLLRCSRCRSSFYCCKEHQRQD...unknown
Hypoxia-inducible factor 1-alphaMEGAGGANDKKKISSERRKEKSRDAARSRRSKESEVFYELAHQLPLPHNV...unknown
Drug Info/Drug Targets: DrugBank 3.0: a comprehensive resource for 'omics' research on drugs. Knox C, Law V, Jewison T, Liu P, Ly S, Frolkis A, Pon A, Banco K, Mak C, Neveu V, Djoumbou Y, Eisner R, Guo AC, Wishart DS. Nucleic Acids Res. 2011 Jan; 39 (Database issue):D1035-41. | PMID:21059682

Related Resource References

Resource NameReference
Pharos CHEMBL426560
PubChem 6914666
ChEMBL CHEMBL426560