URE

UREA

Find entries where: URE

is present as a standalone ligand in 86 entries

is present in a polymer sequence 1 entries

Find related ligands:

Similar Ligands (Stereospecific)

Similar Ligands (Quick Screen)

Toggle Hydrogen Toggle Labels

Chemical Component Summary
Name	UREA
Identifiers	urea
Formula	C H₄ N₂ O
Molecular Weight	60.055
Type	NON-POLYMER
Isomeric SMILES	C(=O)(N)N
InChI	InChI=1S/CH4N2O/c2-1(3)4/h(H4,2,3,4)
InChIKey	XSQUKJJJFZCRTK-UHFFFAOYSA-N

Chemical Details
Formal Charge	0
Atom Count	8
Chiral Atom Count	0
Bond Count	7
Aromatic Bond Count	0

Drug Info: DrugBank

DrugBank ID	DB03904
Name	Urea
Groups	approved investigational
Description	A compound formed in the liver from ammonia produced by the deamination of amino acids. It is the principal end product of protein catabolism and constitutes about one half of the total urinary solids.
Synonyms	Urea Carbonyldiamide Harnstoff Karbamid Carbamide Urée
Brand Names	Carb-O-Philic Ciclopirox 3% / Itraconazole 5% / Urea 20% Clear 40 Plus HA Urea 47 Pedipak Umecta Urea Urederm Cream 10% Clear 50 Nail Gel Urea 40 Plus HA Urea Hydrating Topical Urea 40 Bare 40 Psoricare Crm 3% Urea 39% Cream Urea 39.5% with 2% Salicylic Acid Umecta PD Urea Xurea Uremol Calmurid HC Crm Gehwol med Callus Gordons Urea 40 Ti-U-lac Lotion Keratol 45 cream Uramaxin Pads Revitaderm 40 Velvelan Crm 10% Urea 50 Urea Uramaxin Thomas Formula No 28 Bare 40 HA Kerasal Topical Solution Urealac Bare 20 Pro-39 Urea Urea 40 Percent Dermetazole Uramaxin TS Amino-cerv Bare 40 Plus SA Urea 40 Plus SA Uremol 20% cream Miracle FootCream Lemon Miracle FootCream Lavender Thomas Formula No 17 Urea 20 Urea 41 Percent Dermasorb XM Complete Kit Miin Foot Kerafoam 42 U40 Clear 40 Keratol 45 Nail X Viate Uremol 10 Crm 10% Ure-K Urea 47% Cream Keralac Nailstik YouGreen F Not Applicable Uramaxin GT Rea Lo 39 Velvelan Lot 10% Utopic Urea Cream 40 Percent Lactic Acid 10% / Urea 40% Urea 39.5% Bare 40 Plus HA Urevaz Gehwol med Lipidro Urea Nail Aluvea MeTopic Rea Lo 40 Flexitol Heel Balm Gehwol FUSSKRAFT Callus Softener Urea 50% Emulsion Bare 40 SA Urea 40 Nail Gel Hyaluronic Acid Sodium Salt 1% / Tacrolimus 0.1% / Urea 20% Kerafoam Clear 40 Plus SA Uremol 10 Lotion 10% Urea Cream 40% Podiatrole Remeven W.skin Cica Foot Peeling Coppermagic Pain Relief Balm Uremol HC CEM-Urea Carmol 40 Urea 41% Urea 40% Thomas Formula No 47 Ti-U-lac HC Lotion Noxipak Hydrophil Ont Keralac Heel Balm Urea Gel 40% Urea Cream 41% X-Viate Keratol 40 Latrix Re Urea Dr. Scholl's Cracked Heel Relief Cream Calmurid Crm Carbamex 330mgms RE Urea Ure-39 Kerol AD Umecta Mousse Urea Hydro 35 Rynoderm
Indication	Urea is used topically for debridement and promotion of normal healing of hyperkeratotic surface lesions, particularly where healing is retarded by local infection, necrotic tissue, fibrinous or purulent debris or eschar. Urea is useful for the treatment of hyperkeratotic conditions such as dry, rough skin, dermatitis, psoriasis, xerosis, ichthyosis, eczema, keratosis, keratoderma, corns and calluses, as well as damaged, devitalized and ingrown nails.[L41484]
Categories	Amides Blood and Blood Forming Organs Blood Substitutes and Perfusion Solutions Carbamide products Dermatologicals Diuretics, Osmotic Emollients and Protectives i.v. Solutions Keratolytic Agents Solutions Producing Osmotic Diuresis
ATC-Code	D02AE01 B05BC02 D02AE51
CAS number	57-13-6

Drug Targets

Name	Target Sequence	Pharmacological Action	Actions
Dihydrofolate reductase	VRSLNSIVAVCQNMGIGKDGNLPWPPLRNEYKYFQRMTSTSHVEGKQNAV...	unknown	activator
Arginase-1	MSAKSRTIGIIGAPFSKGQPRGGVEEGPTVLRKAGLLEKLKEQECDVKDY...	unknown
Carbonic anhydrase 2	MSHHWGYGKHNGPEHWHKDFPIAKGERQSPVDIDTHTAKYDPSLKPLSVS...	unknown
Catenin beta-1	MATQADLMELDMAMEPDRKAAVSHWQQQSYLDSGIHSGATTTAPSLSGKG...	unknown
Sulfoxide reductase catalytic subunit YedY	MKKNQFLKESDVTAESVFFMKRRQVLKALGISAAALSLPHAAHADLLSWF...	unknown
Urea transporter 2	MSDPHSSPLLPEPLSSRYKLYEAEFTSPSWPSTSPDTHPALPLLEMPEEK...	unknown	substrate
Urea transporter 1	MEDSPTMVRVDSPTMVRGENQVSPCQGRRCFPKALGYVTGDMKELANQLK...	unknown	substrate
View More

Drug Info/Drug Targets: DrugBank 3.0: a comprehensive resource for 'omics' research on drugs. Knox C, Law V, Jewison T, Liu P, Ly S, Frolkis A, Pon A, Banco K, Mak C, Neveu V, Djoumbou Y, Eisner R, Guo AC, Wishart DS. Nucleic Acids Res. 2011 Jan; 39 (Database issue):D1035-41. | PMID:21059682

Related Resource References

Resource Name	Reference
Pharos	CHEMBL985
PubChem	1176
ChEMBL	CHEMBL985
ChEBI	CHEBI:16199, CHEBI:48376
CCDC/CSD	ACUFUR01, ACUYAY, BARBUR01, ACUYEC, AZUQAP, BARBUR02, BARBUR06, BARBUR03, BARBUR04, BARBUR05, BARBUR, AWISOO, ACUFUR, BAFTEH, BAQZOI, AMIMAK, AMILUD01, AMILUD, AMILEN, BAFSOQ, AWISUU, BAFWIO, AMILEN01, ARAMEO, AQUMIL01, AQUMIL
COD	2016711, 2016712, 1008775, 1008776, 1008786, 1008787, 2019369, 2311086, 1544223, 1544224, 1544225, 1544226, 2022025, 2003112

RCSB PDB Core Operations are funded by the U.S. National Science Foundation (DBI-2321666), the US Department of Energy (DE-SC0019749), and the National Cancer Institute, National Institute of Allergy and Infectious Diseases, and National Institute of General Medical Sciences of the National Institutes of Health under grant R01GM157729.

Prepare Data

Validate Data

Deposit Data

Help and Resources

URE

UREA

Chemical Component Summary

Chemical Details

Drug Info: DrugBank

Drug Targets

Related Resource References