Z12

2,4-dichloro-N-[3,5-dichloro-4-(quinolin-3-yloxy)phenyl]benzenesulfonamide


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Chemical Component Summary

Name2,4-dichloro-N-[3,5-dichloro-4-(quinolin-3-yloxy)phenyl]benzenesulfonamide
Identifiers2,4-dichloro-N-(3,5-dichloro-4-quinolin-3-yloxy-phenyl)benzenesulfonamide
FormulaC21 H12 Cl4 N2 O3 S
Molecular Weight514.209
TypeNON-POLYMER
Isomeric SMILESc1ccc2c(c1)cc(cn2)Oc3c(cc(cc3Cl)NS(=O)(=O)c4ccc(cc4Cl)Cl)Cl
InChIInChI=1S/C21H12Cl4N2O3S/c22-13-5-6-20(16(23)8-13)31(28,29)27-14-9-17(24)21(18(25)10-14)30-15-7-12-3-1-2-4-19(12)26-11-15/h1-11,27H
InChIKeyNMRWDFUZLLQSBN-UHFFFAOYSA-N

Chemical Details

Formal Charge0
Atom Count43
Chiral Atom Count0
Bond Count46
Aromatic Bond Count23

Drug Info: DrugBank

DrugBank IDDB05490 
NameAMG-131
Groups investigational
DescriptionAMG-131 (T131), an orally-administered therapy, is expected to lower blood glucose in type II diabetic patients by improving the body’s ability to respond to insulin. T131 is a selective modulator of PPARg (peroxisome proliferator activated receptor gamma), a receptor involved in regulating the body’s ability to respond to insulin. T131 is not structurally related to the thiazolidinedione class of PPARg agonists, which includes Actos and Avandia.
SynonymsAMG-131
IndicationInvestigated for use/treatment in diabetes mellitus type 2.
Categories
  • Amides
  • Heterocyclic Compounds, Fused-Ring
  • PPAR gamma, agonists
  • Sulfones
  • Sulfur Compounds
CAS number315224-26-1

Drug Targets

NameTarget SequencePharmacological ActionActions
Peroxisome proliferator-activated receptor gammaMGETLGDSPIDPESDSFTDTLSANISQEMTMVDTEMPFWPTNFGISSVDL...unknownpartial agonist
Drug Info/Drug Targets: DrugBank 3.0: a comprehensive resource for 'omics' research on drugs. Knox C, Law V, Jewison T, Liu P, Ly S, Frolkis A, Pon A, Banco K, Mak C, Neveu V, Djoumbou Y, Eisner R, Guo AC, Wishart DS. Nucleic Acids Res. 2011 Jan; 39 (Database issue):D1035-41. | PMID:21059682

Related Resource References

Resource NameReference
Pharos CHEMBL1236924
PubChem 10229498
ChEMBL CHEMBL1236924