Download MendeleyStructure of an Enzyme-Substrate Complex and the Catalytic Mechanism of Human Brain Myo-Inositol Monophosphatase
Ganzhorn, A.J., Rondeau, J.-M.(1997) Protein Eng 10: 61
1AWB
HUMAN MYO-INOSITOL MONOPHOSPHATASE IN COMPLEX WITH D-INOSITOL-1-PHOSPHATE AND CALCIUM
- PDB DOI: https://doi.org/10.2210/pdb1AWB/pdb
- Classification: HYDROLASE
- Organism(s): Homo sapiens
- Expression System: Escherichia coli
- Mutation(s): No
- Deposited: 1997-10-01 Released: 1998-01-14
Experimental Data Snapshot
- Method: X-RAY DIFFRACTION
- Resolution: 2.50 Å
- R-Value Free: 0.189
- R-Value Work: 0.153
- R-Value Observed: 0.153
Starting Model: experimental
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This is version 1.5 of the entry. See complete history.
Literature
Macromolecules
Find similar proteins by:
(by identity cutoff) | 3D Structure
Entity ID: 1 | |||||
|---|---|---|---|---|---|
| Molecule | Chains | Sequence Length | Organism | Details | Image |
| MYO-INOSITOL MONOPHOSPHATASE | 276 | Homo sapiens | Mutation(s): 0 Gene Names: IMPA EC: 3.1.3.25 (PDB Primary Data), 3.1.3.94 (UniProt) |  | |
UniProt & NIH Common Fund Data Resources | |||||
Find proteins for P29218 (Homo sapiens) Explore P29218 Go to UniProtKB: P29218 | |||||
PHAROS: P29218 GTEx: ENSG00000133731 | |||||
Entity Groups | |||||
| Sequence Clusters | 30% Identity50% Identity70% Identity90% Identity95% Identity100% Identity | ||||
| UniProt Group | P29218 | ||||
Sequence AnnotationsExpand | |||||
| |||||
Small Molecules
| Ligands 3 Unique | |||||
|---|---|---|---|---|---|
| ID | Chains | Name / Formula / InChI Key | 2D Diagram | 3D Interactions | |
| IPD Query on IPD | G [auth A], L [auth B] | D-MYO-INOSITOL-1-PHOSPHATE C6 H11 O9 P INAPMGSXUVUWAF-UOTPTPDRSA-L |  | ||
| CA Query on CA | C [auth A] D [auth A] E [auth A] H [auth B] I [auth B] | CALCIUM ION Ca BHPQYMZQTOCNFJ-UHFFFAOYSA-N |  | ||
| CL Query on CL | F [auth A], K [auth B] | CHLORIDE ION Cl VEXZGXHMUGYJMC-UHFFFAOYSA-M |  | ||
Experimental Data & Validation
Experimental Data
- Method: X-RAY DIFFRACTION
- Resolution: 2.50 Å
- R-Value Free: 0.189
- R-Value Work: 0.153
- R-Value Observed: 0.153
- Space Group: P 32 2 1
Unit Cell:
| Length ( Å ) | Angle ( ˚ ) |
|---|---|
| a = 86.37 | α = 90 |
| b = 86.37 | β = 90 |
| c = 153.795 | γ = 120 |
| Software Name | Purpose |
|---|---|
| XDS | data scaling |
| XSCALE | data scaling |
| X-PLOR | model building |
| X-PLOR | refinement |
| XDS | data reduction |
| X-PLOR | phasing |
Entry History
Deposition Data
- Released Date: 1998-01-14 Deposition Author(s): Rondeau, J.-M., Pelton, P.D., Vincendon, P., Ganzhorn, A.J.
Revision History (Full details and data files)
- Version 1.0: 1998-01-14
Type: Initial release - Version 1.1: 2008-03-03
Changes: Version format compliance - Version 1.2: 2011-07-13
Changes: Version format compliance - Version 1.3: 2018-04-04
Changes: Data collection - Version 1.4: 2023-08-02
Changes: Database references, Derived calculations, Refinement description - Version 1.5: 2024-11-06
Changes: Data collection, Structure summary
