Download MendeleySaicar Synthase: Substrate Recognition, Conformational Flexibility and Catalysis.
Urusova, D.V., Antonyuk, S.V., Grebenko, A.I., Levdikov, V.M., Barynin, V.V., Popov, A.N., Lamzin, V.S., Melik-Adamyan, W.R.To be published.
2CNQ
Atomic resolution structure of SAICAR-synthase from Saccharomyces cerevisiae complexed with ADP, AICAR, succinate
- PDB DOI: https://doi.org/10.2210/pdb2CNQ/pdb
- Classification: LIGASE
- Organism(s): Saccharomyces cerevisiae
- Mutation(s): No
- Deposited: 2006-05-23 Released: 2006-06-08
Experimental Data Snapshot
- Method: X-RAY DIFFRACTION
- Resolution: 1.00 Å
- R-Value Free: 0.130
- R-Value Work: 0.115
- R-Value Observed: 0.116
Starting Model: experimental
View more details
This is version 2.4 of the entry. See complete history.
Literature
To be published.
Macromolecules
Find similar proteins by:
(by identity cutoff) | 3D Structure
Entity ID: 1 | |||||
|---|---|---|---|---|---|
| Molecule | Chains | Sequence Length | Organism | Details | Image |
| PHOSPHORIBOSYLAMINOIMIDAZOLE-SUCCINOCARBOXAMIDE SYNTHASE | 306 | Saccharomyces cerevisiae | Mutation(s): 0 EC: 6.3.2.6 |  | |
UniProt | |||||
Find proteins for P27616 (Saccharomyces cerevisiae (strain ATCC 204508 / S288c)) Explore P27616 Go to UniProtKB: P27616 | |||||
Entity Groups | |||||
| Sequence Clusters | 30% Identity50% Identity70% Identity90% Identity95% Identity100% Identity | ||||
| UniProt Group | P27616 | ||||
Sequence AnnotationsExpand | |||||
| |||||
Small Molecules
| Ligands 6 Unique | |||||
|---|---|---|---|---|---|
| ID | Chains | Name / Formula / InChI Key | 2D Diagram | 3D Interactions | |
| ADP Query on ADP | B [auth A], F [auth A] | ADENOSINE-5'-DIPHOSPHATE C10 H15 N5 O10 P2 XTWYTFMLZFPYCI-KQYNXXCUSA-N |  | ||
| AMP Query on AMP | E [auth A] | ADENOSINE MONOPHOSPHATE C10 H14 N5 O7 P UDMBCSSLTHHNCD-KQYNXXCUSA-N |  | ||
| AMZ Query on AMZ | C [auth A], D [auth A] | AMINOIMIDAZOLE 4-CARBOXAMIDE RIBONUCLEOTIDE C9 H15 N4 O8 P NOTGFIUVDGNKRI-UUOKFMHZSA-N |  | ||
| SIN Query on SIN | G [auth A], H [auth A] | SUCCINIC ACID C4 H6 O4 KDYFGRWQOYBRFD-UHFFFAOYSA-N |  | ||
| SO4 Query on SO4 | J [auth A], K [auth A], L [auth A], M [auth A] | SULFATE ION O4 S QAOWNCQODCNURD-UHFFFAOYSA-L |  | ||
| MG Query on MG | I [auth A] | MAGNESIUM ION Mg JLVVSXFLKOJNIY-UHFFFAOYSA-N |  | ||
Experimental Data & Validation
Experimental Data
- Method: X-RAY DIFFRACTION
- Resolution: 1.00 Å
- R-Value Free: 0.130
- R-Value Work: 0.115
- R-Value Observed: 0.116
- Space Group: P 21 21 21
Unit Cell:
| Length ( Å ) | Angle ( ˚ ) |
|---|---|
| a = 60.683 | α = 90 |
| b = 61.851 | β = 90 |
| c = 76.893 | γ = 90 |
| Software Name | Purpose |
|---|---|
| REFMAC | refinement |
| DENZO | data reduction |
| SCALEPACK | data scaling |
| MOLREP | phasing |
Entry History
Deposition Data
- Released Date: 2006-06-08 Deposition Author(s): Urusova, D.V., Antonyuk, S.V., Grebenko, A.I., Levdikov, V.M., Barynin, V.V., Popov, A.N., Lamzin, V.S., Melik-Adamyan, W.R.
Revision History (Full details and data files)
- Version 1.0: 2006-06-08
Type: Initial release - Version 1.1: 2011-05-08
Changes: Version format compliance - Version 1.2: 2011-07-13
Changes: Version format compliance - Version 2.0: 2018-12-19
Changes: Advisory, Atomic model, Data collection, Derived calculations - Version 2.1: 2019-07-10
Changes: Data collection, Derived calculations - Version 2.2: 2019-07-24
Changes: Data collection - Version 2.3: 2023-12-13
Changes: Advisory, Data collection, Database references, Derived calculations, Other, Refinement description - Version 2.4: 2024-11-13
Changes: Structure summary
