Download MendeleyThe Crystal Structure of Human methyltransferase 10 domain containing protein.
Wu, H., Min, J., Zeng, H., Loppnau, P., Weigelt, J., Sundstrom, M., Arrowsmith, C.H., Edwards, A.M., Bochkarev, A., Plotnikov, A.N.To be published.
2H00
Human methyltransferase 10 domain containing protein
- PDB DOI: https://doi.org/10.2210/pdb2H00/pdb
- Classification: TRANSFERASE
- Organism(s): Homo sapiens
- Expression System: Escherichia coli
- Mutation(s): No
- Deposited: 2006-05-12 Released: 2006-06-13
Experimental Data Snapshot
- Method: X-RAY DIFFRACTION
- Resolution: 2.00 Å
- R-Value Free: 0.274
- R-Value Work: 0.221
- R-Value Observed: 0.223
This is version 1.3 of the entry. See complete history.
Literature
To be published.
Macromolecules
Find similar proteins by:
(by identity cutoff) | 3D Structure
Entity ID: 1 | |||||
|---|---|---|---|---|---|
| Molecule | Chains | Sequence Length | Organism | Details | Image |
| methyltransferase 10 domain containing protein | 254 | Homo sapiens | Mutation(s): 0 EC: 2.1.1.346 (UniProt), 2.1.1.348 (UniProt) |  | |
UniProt & NIH Common Fund Data Resources | |||||
Find proteins for Q86W50 (Homo sapiens) Explore Q86W50 Go to UniProtKB: Q86W50 | |||||
PHAROS: Q86W50 GTEx: ENSG00000127804 | |||||
Entity Groups | |||||
| Sequence Clusters | 30% Identity50% Identity70% Identity90% Identity95% Identity100% Identity | ||||
| UniProt Group | Q86W50 | ||||
Sequence AnnotationsExpand | |||||
| |||||
Small Molecules
| Ligands 3 Unique | |||||
|---|---|---|---|---|---|
| ID | Chains | Name / Formula / InChI Key | 2D Diagram | 3D Interactions | |
| SAH Query on SAH | D [auth A], G [auth B], I [auth C] | S-ADENOSYL-L-HOMOCYSTEINE C14 H20 N6 O5 S ZJUKTBDSGOFHSH-WFMPWKQPSA-N |  | ||
| DTU Query on DTU | E [auth A] | (2R,3S)-1,4-DIMERCAPTOBUTANE-2,3-DIOL C4 H10 O2 S2 VHJLVAABSRFDPM-ZXZARUISSA-N |  | ||
| CL Query on CL | F [auth B], H [auth C] | CHLORIDE ION Cl VEXZGXHMUGYJMC-UHFFFAOYSA-M |  | ||
Experimental Data & Validation
Experimental Data
- Method: X-RAY DIFFRACTION
- Resolution: 2.00 Å
- R-Value Free: 0.274
- R-Value Work: 0.221
- R-Value Observed: 0.223
- Space Group: P 31 2 1
Unit Cell:
| Length ( Å ) | Angle ( ˚ ) |
|---|---|
| a = 133.737 | α = 90 |
| b = 133.737 | β = 90 |
| c = 78.833 | γ = 120 |
| Software Name | Purpose |
|---|---|
| REFMAC | refinement |
| CrystalClear | data reduction |
| HKL-2000 | data scaling |
| SOLVE | phasing |
Entry History
Deposition Data
- Released Date: 2006-06-13 Deposition Author(s): Min, J.R., Wu, H., Zeng, H., Loppnau, P., Weigelt, J., Sundstrom, M., Arrowsmith, C.H., Edwards, A.M., Bochkarev, A., Plotnikov, A.N., Structural Genomics Consortium (SGC)
Revision History (Full details and data files)
- Version 1.0: 2006-06-13
Type: Initial release - Version 1.1: 2008-05-01
Changes: Version format compliance - Version 1.2: 2011-07-13
Changes: Version format compliance - Version 1.3: 2024-02-14
Changes: Data collection, Database references, Derived calculations
