Download MendeleyMouse thymidylate synthase does not show the inactive conformation, observed for the human enzyme
Dowiercial, A., Jarmula, A., Wilk, P., Rypniewski, W., Kowalska, M., Fraczyk, T., Ciesla, J., Rode, W.(2016) Struct Chem
3IHI
Crystal structure of mouse thymidylate synthase
- PDB DOI: https://doi.org/10.2210/pdb3IHI/pdb
- Classification: TRANSFERASE
- Organism(s): Mus musculus
- Expression System: Escherichia coli
- Mutation(s): No
- Deposited: 2009-07-30 Released: 2010-02-02
Experimental Data Snapshot
- Method: X-RAY DIFFRACTION
- Resolution: 1.94 Å
- R-Value Free: 0.266
- R-Value Work: 0.220
- R-Value Observed: 0.221
Starting Model: experimental
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wwPDB Validation 3D Report Full Report
This is version 1.4 of the entry. See complete history.
Literature
Macromolecules
Find similar proteins by:
(by identity cutoff) | 3D Structure
Entity ID: 1 | |||||
|---|---|---|---|---|---|
| Molecule | Chains | Sequence Length | Organism | Details | Image |
| Thymidylate synthase | 307 | Mus musculus | Mutation(s): 0 Gene Names: Tyms EC: 2.1.1.45 |  | |
UniProt | |||||
Find proteins for P07607 (Mus musculus) Explore P07607 Go to UniProtKB: P07607 | |||||
Entity Groups | |||||
| Sequence Clusters | 30% Identity50% Identity70% Identity90% Identity95% Identity100% Identity | ||||
| UniProt Group | P07607 | ||||
Sequence AnnotationsExpand | |||||
| |||||
Small Molecules
| Ligands 1 Unique | |||||
|---|---|---|---|---|---|
| ID | Chains | Name / Formula / InChI Key | 2D Diagram | 3D Interactions | |
| SO4 Query on SO4 | C [auth A], D [auth B] | SULFATE ION O4 S QAOWNCQODCNURD-UHFFFAOYSA-L |  | ||
Experimental Data & Validation
Experimental Data
- Method: X-RAY DIFFRACTION
- Resolution: 1.94 Å
- R-Value Free: 0.266
- R-Value Work: 0.220
- R-Value Observed: 0.221
- Space Group: C 1 2 1
Unit Cell:
| Length ( Å ) | Angle ( ˚ ) |
|---|---|
| a = 158.202 | α = 90 |
| b = 87.962 | β = 97.43 |
| c = 68.043 | γ = 90 |
| Software Name | Purpose |
|---|---|
| DENZO | data reduction |
| SCALEPACK | data scaling |
| REFMAC | refinement |
| PDB_EXTRACT | data extraction |
| MAR345 | data collection |
| MOLREP | phasing |
Entry History
Deposition Data
- Released Date: 2010-02-02 Deposition Author(s): Dowiercial, A., Jarmula, A., Rypniewski, W.R., Sokolowska, M., Fraczyk, T., Ciesla, J., Rode, W.
Revision History (Full details and data files)
- Version 1.0: 2010-02-02
Type: Initial release - Version 1.1: 2011-07-13
Changes: Version format compliance - Version 1.2: 2016-11-02
Changes: Database references - Version 1.3: 2017-11-01
Changes: Data collection, Refinement description - Version 1.4: 2023-09-06
Changes: Data collection, Database references, Derived calculations, Refinement description
