Download MendeleyCrystal structure of human transthyretin variant A25T in complex with flufenamic acid.
Lima, L.M.T.R., Palmieri, L.C., Foguel, D., Palhano, F.L.To be published.
3OZL
Crystal structure of human transthyretin variant A25T in complex with flufenamic acid.
- PDB DOI: https://doi.org/10.2210/pdb3OZL/pdb
- Classification: HORMONE
- Organism(s): Homo sapiens
- Expression System: Escherichia coli
- Mutation(s): Yes
- Deposited: 2010-09-25 Released: 2011-09-28
Experimental Data Snapshot
- Method: X-RAY DIFFRACTION
- Resolution: 1.90 Å
- R-Value Free: 0.247
- R-Value Work: 0.199
- R-Value Observed: 0.201
Starting Model: experimental
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This is version 1.1 of the entry. See complete history.
Literature
To be published.
Macromolecules
Find similar proteins by:
(by identity cutoff) | 3D Structure
Entity ID: 1 | |||||
|---|---|---|---|---|---|
| Molecule | Chains | Sequence Length | Organism | Details | Image |
| Transthyretin | 127 | Homo sapiens | Mutation(s): 1 Gene Names: TTR, PALB |  | |
UniProt & NIH Common Fund Data Resources | |||||
Find proteins for P02766 (Homo sapiens) Explore P02766 Go to UniProtKB: P02766 | |||||
PHAROS: P02766 GTEx: ENSG00000118271 | |||||
Entity Groups | |||||
| Sequence Clusters | 30% Identity50% Identity70% Identity90% Identity95% Identity100% Identity | ||||
| UniProt Group | P02766 | ||||
Sequence AnnotationsExpand | |||||
| |||||
Small Molecules
| Ligands 1 Unique | |||||
|---|---|---|---|---|---|
| ID | Chains | Name / Formula / InChI Key | 2D Diagram | 3D Interactions | |
| FLF Query on FLF | C [auth A], D [auth B] | 2-[[3-(TRIFLUOROMETHYL)PHENYL]AMINO] BENZOIC ACID C14 H10 F3 N O2 LPEPZBJOKDYZAD-UHFFFAOYSA-N |  | ||
Experimental Data & Validation
Experimental Data
- Method: X-RAY DIFFRACTION
- Resolution: 1.90 Å
- R-Value Free: 0.247
- R-Value Work: 0.199
- R-Value Observed: 0.201
- Space Group: P 21 21 2
Unit Cell:
| Length ( Å ) | Angle ( ˚ ) |
|---|---|
| a = 43.93 | α = 90 |
| b = 85.607 | β = 90 |
| c = 65.228 | γ = 90 |
| Software Name | Purpose |
|---|---|
| MOSFLM | data reduction |
| SCALA | data scaling |
| MOLREP | phasing |
| REFMAC | refinement |
| PDB_EXTRACT | data extraction |
| MAR345dtb | data collection |
Entry History
Deposition Data
- Released Date: 2011-09-28 Deposition Author(s): Lima, L.M.T.R., Palmieri, L.C., Foguel, D., Palhano, F.L.
Revision History (Full details and data files)
- Version 1.0: 2011-09-28
Type: Initial release - Version 1.1: 2023-09-06
Changes: Data collection, Database references, Derived calculations, Refinement description
