Download MendeleyStructural and functional analysis of the flexible regions of the catalytic alpha-subunit of protein kinase CK2
Papinutto, E., Ranchio, A., Lolli, G., Pinna, L.A., Battistutta, R.To be published.
3Q9W
Crystal structure of human CK2 alpha in complex with emodin at pH 8.5
- PDB DOI: https://doi.org/10.2210/pdb3Q9W/pdb
- Classification: TRANSFERASE/TRANSFERASE INHIBITOR
- Organism(s): Homo sapiens
- Expression System: Escherichia coli
- Mutation(s): No
- Deposited: 2011-01-10 Released: 2012-01-11
Experimental Data Snapshot
- Method: X-RAY DIFFRACTION
- Resolution: 1.70 Å
- R-Value Free: 0.223
- R-Value Work: 0.170
- R-Value Observed: 0.173
Starting Model: experimental
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This is version 1.1 of the entry. See complete history.
Literature
To be published.
Macromolecules
Find similar proteins by:
(by identity cutoff) | 3D Structure
Entity ID: 1 | |||||
|---|---|---|---|---|---|
| Molecule | Chains | Sequence Length | Organism | Details | Image |
| Casein kinase II subunit alpha | 336 | Homo sapiens | Mutation(s): 0 Gene Names: CSNK2A1, CK2A1 EC: 2.7.11.1 |  | |
UniProt & NIH Common Fund Data Resources | |||||
Find proteins for P68400 (Homo sapiens) Explore P68400 Go to UniProtKB: P68400 | |||||
PHAROS: P68400 GTEx: ENSG00000101266 | |||||
Entity Groups | |||||
| Sequence Clusters | 30% Identity50% Identity70% Identity90% Identity95% Identity100% Identity | ||||
| UniProt Group | P68400 | ||||
Sequence AnnotationsExpand | |||||
| |||||
Small Molecules
| Ligands 2 Unique | |||||
|---|---|---|---|---|---|
| ID | Chains | Name / Formula / InChI Key | 2D Diagram | 3D Interactions | |
| EMO Query on EMO | B [auth A] | 3-METHYL-1,6,8-TRIHYDROXYANTHRAQUINONE C15 H10 O5 RHMXXJGYXNZAPX-UHFFFAOYSA-N |  | ||
| SO4 Query on SO4 | C [auth A], D [auth A], E [auth A] | SULFATE ION O4 S QAOWNCQODCNURD-UHFFFAOYSA-L |  | ||
Experimental Data & Validation
Experimental Data
- Method: X-RAY DIFFRACTION
- Resolution: 1.70 Å
- R-Value Free: 0.223
- R-Value Work: 0.170
- R-Value Observed: 0.173
- Space Group: P 1 21 1
Unit Cell:
| Length ( Å ) | Angle ( ˚ ) |
|---|---|
| a = 58.337 | α = 90 |
| b = 45.619 | β = 111.88 |
| c = 62.613 | γ = 90 |
| Software Name | Purpose |
|---|---|
| SCALA | data scaling |
| REFMAC | refinement |
| PDB_EXTRACT | data extraction |
| ProDC | data collection |
| MOSFLM | data reduction |
| PHASER | phasing |
Entry History
Deposition Data
- Released Date: 2012-01-11 Deposition Author(s): Battistutta, R., Ranchio, A., Papinutto, E.
Revision History (Full details and data files)
- Version 1.0: 2012-01-11
Type: Initial release - Version 1.1: 2023-11-01
Changes: Data collection, Database references, Derived calculations, Refinement description
