Structure of human Leukotriene A4 hydrolase in complex with inhibitor sc57461A
Olsson, U., Niegowski, D., Stsiapanava, A., Thunnissen, M., Haeggstrom, J.Z., Rinaldo-Matthis, A.To be published.
Experimental Data Snapshot
Entity ID: 1 | |||||
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Molecule | Chains | Sequence Length | Organism | Details | Image |
Leukotriene A-4 hydrolase | 608 | Homo sapiens | Mutation(s): 0  Gene Names: LTA4H, LTA4 EC: 3.3.2.6 (PDB Primary Data), 3.4.11.4 (UniProt) | ||
UniProt & NIH Common Fund Data Resources | |||||
Find proteins for P09960 (Homo sapiens) Explore P09960  Go to UniProtKB:  P09960 | |||||
PHAROS:  P09960 GTEx:  ENSG00000111144  | |||||
Entity Groups   | |||||
Sequence Clusters | 30% Identity50% Identity70% Identity90% Identity95% Identity100% Identity | ||||
UniProt Group | P09960 | ||||
Sequence AnnotationsExpand | |||||
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Ligands 7 Unique | |||||
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ID | Chains | Name / Formula / InChI Key | 2D Diagram | 3D Interactions | |
28P Query on 28P | I [auth A] | N-[3-(4-benzylphenoxy)propyl]-N-methyl-beta-alanine C20 H25 N O3 HSXNVULMYZGNGF-UHFFFAOYSA-N | |||
YB Query on YB | C [auth A] K [auth A] L [auth A] M [auth A] N [auth A] | YTTERBIUM (III) ION Yb AWSFICBXMUKWSK-UHFFFAOYSA-N | |||
GOL Query on GOL | H [auth A] | GLYCEROL C3 H8 O3 PEDCQBHIVMGVHV-UHFFFAOYSA-N | |||
IMD Query on IMD | F [auth A], G [auth A], R [auth A] | IMIDAZOLE C3 H5 N2 RAXXELZNTBOGNW-UHFFFAOYSA-O | |||
ZN Query on ZN | B [auth A] | ZINC ION Zn PTFCDOFLOPIGGS-UHFFFAOYSA-N | |||
ACT Query on ACT | J [auth A] | ACETATE ION C2 H3 O2 QTBSBXVTEAMEQO-UHFFFAOYSA-M | |||
CL Query on CL | D [auth A], E [auth A] | CHLORIDE ION Cl VEXZGXHMUGYJMC-UHFFFAOYSA-M |
Length ( Å ) | Angle ( ˚ ) |
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a = 78.078 | α = 90 |
b = 86.799 | β = 90 |
c = 99.145 | γ = 90 |
Software Name | Purpose |
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XSCALE | data scaling |
REFMAC | refinement |
PDB_EXTRACT | data extraction |
AUTOMAR | data collection |