Download MendeleyHydrophobic Central Cavity in Fructose-1,6-bisphosphatase is Essential for the Synergism in AMP/Fru 2,6-bisphosphate Inhibition
Gao, Y., Shen, L., Honzatko, R.B.To be published.
4GWU
Crystal Structure of Fru 2,6-bisphosphate complexes of Porcine Liver Fructose-1,6-bisphosphatase with Filled Central Cavity
- PDB DOI: https://doi.org/10.2210/pdb4GWU/pdb
- Classification: HYDROLASE
- Organism(s): Sus scrofa
- Expression System: Escherichia coli
- Mutation(s): Yes
- Deposited: 2012-09-03 Released: 2013-09-04
Experimental Data Snapshot
- Method: X-RAY DIFFRACTION
- Resolution: 3.00 Å
- R-Value Free: 0.289
- R-Value Work: 0.231
- R-Value Observed: 0.234
Starting Model: experimental
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This is version 1.2 of the entry. See complete history.
Literature
To be published.
Macromolecules
Find similar proteins by:
(by identity cutoff) | 3D Structure
Entity ID: 1 | |||||
|---|---|---|---|---|---|
| Molecule | Chains | Sequence Length | Organism | Details | Image |
| Fructose-1,6-bisphosphatase 1 | 337 | Sus scrofa | Mutation(s): 3 Gene Names: FBP, FBP1 EC: 3.1.3.11 |  | |
UniProt | |||||
Find proteins for P00636 (Sus scrofa) Explore P00636 Go to UniProtKB: P00636 | |||||
Entity Groups | |||||
| Sequence Clusters | 30% Identity50% Identity70% Identity90% Identity95% Identity100% Identity | ||||
| UniProt Group | P00636 | ||||
Sequence AnnotationsExpand | |||||
| |||||
Small Molecules
| Ligands 2 Unique | |||||
|---|---|---|---|---|---|
| ID | Chains | Name / Formula / InChI Key | 2D Diagram | 3D Interactions | |
| FDP Query on FDP | B [auth A] | 2,6-di-O-phosphono-beta-D-fructofuranose C6 H14 O12 P2 YXWOAJXNVLXPMU-ZXXMMSQZSA-N |  | ||
| MG Query on MG | C [auth A] | MAGNESIUM ION Mg JLVVSXFLKOJNIY-UHFFFAOYSA-N |  | ||
Experimental Data & Validation
Experimental Data
- Method: X-RAY DIFFRACTION
- Resolution: 3.00 Å
- R-Value Free: 0.289
- R-Value Work: 0.231
- R-Value Observed: 0.234
- Space Group: I 2 2 2
Unit Cell:
| Length ( Å ) | Angle ( ˚ ) |
|---|---|
| a = 53.999 | α = 90 |
| b = 81.221 | β = 90 |
| c = 165.058 | γ = 90 |
| Software Name | Purpose |
|---|---|
| d*TREK | data scaling |
| d*TREK | data reduction |
| MOLREP | phasing |
| REFMAC | refinement |
| PDB_EXTRACT | data extraction |
| CrystalClear | data collection |
Entry History
Deposition Data
- Released Date: 2013-09-04 Deposition Author(s): Gao, Y., Honzatko, R.B.
Revision History (Full details and data files)
- Version 1.0: 2013-09-04
Type: Initial release - Version 1.1: 2020-07-29
Type: Remediation
Reason: Carbohydrate remediation
Changes: Data collection, Database references, Derived calculations, Structure summary - Version 1.2: 2023-09-13
Changes: Data collection, Database references, Refinement description, Structure summary
