Download MendeleyCrystal structure of wild-type human transthyretin in complex with sulindac
Lima, L.M.T.R.To be published.
4IKK
Crystal structure of wild-type human transthyretin in complex with sulindac
- PDB DOI: https://doi.org/10.2210/pdb4IKK/pdb
- Classification: TRANSPORT PROTEIN
- Organism(s): Homo sapiens
- Expression System: Escherichia coli
- Mutation(s): No
- Deposited: 2012-12-26 Released: 2013-01-30
Experimental Data Snapshot
- Method: X-RAY DIFFRACTION
- Resolution: 1.90 Å
- R-Value Free: 0.250
- R-Value Work: 0.199
- R-Value Observed: 0.202
This is version 1.1 of the entry. See complete history.
Literature
To be published.
Macromolecules
Find similar proteins by:
(by identity cutoff) | 3D Structure
Entity ID: 1 | |||||
|---|---|---|---|---|---|
| Molecule | Chains | Sequence Length | Organism | Details | Image |
| Transthyretin | 127 | Homo sapiens | Mutation(s): 0 Gene Names: TTR, PALB |  | |
UniProt & NIH Common Fund Data Resources | |||||
Find proteins for P02766 (Homo sapiens) Explore P02766 Go to UniProtKB: P02766 | |||||
PHAROS: P02766 GTEx: ENSG00000118271 | |||||
Entity Groups | |||||
| Sequence Clusters | 30% Identity50% Identity70% Identity90% Identity95% Identity100% Identity | ||||
| UniProt Group | P02766 | ||||
Sequence AnnotationsExpand | |||||
| |||||
Small Molecules
| Ligands 1 Unique | |||||
|---|---|---|---|---|---|
| ID | Chains | Name / Formula / InChI Key | 2D Diagram | 3D Interactions | |
| SUZ Query on SUZ | C [auth A], D [auth B] | [(1Z)-5-fluoro-2-methyl-1-{4-[methylsulfinyl]benzylidene}-1H-inden-3-yl]acetic acid C20 H17 F O3 S MLKXDPUZXIRXEP-LQVWSKNFSA-N |  | ||
Experimental Data & Validation
Experimental Data
- Method: X-RAY DIFFRACTION
- Resolution: 1.90 Å
- R-Value Free: 0.250
- R-Value Work: 0.199
- R-Value Observed: 0.202
- Space Group: P 21 21 2
Unit Cell:
| Length ( Å ) | Angle ( ˚ ) |
|---|---|
| a = 41.51 | α = 90 |
| b = 83.13 | β = 90 |
| c = 63.72 | γ = 90 |
| Software Name | Purpose |
|---|---|
| MOSFLM | data reduction |
| SCALA | data scaling |
| MOLREP | phasing |
| REFMAC | refinement |
| PDB_EXTRACT | data extraction |
| MAR345dtb | data collection |
Entry History
Deposition Data
- Released Date: 2013-01-30 Deposition Author(s): Lima, L.M.T.R.
Revision History (Full details and data files)
- Version 1.0: 2013-01-30
Type: Initial release - Version 1.1: 2024-03-20
Changes: Data collection, Database references, Derived calculations
