Download MendeleyStructure of PAItrap, an uPA mutant
Gong, L., Proulle, V., Hong, Z., Lin, Z., Liu, M., Yuan, C., Lin, L., Furie, B., Flaumenhaft, R., Andreasen, P., Furie, B., Huang, M.To be published.
4XSK
Structure of PAItrap, an uPA mutant
- PDB DOI: https://doi.org/10.2210/pdb4XSK/pdb
- Classification: BLOOD CLOTTING
- Organism(s): Homo sapiens
- Expression System: Komagataella phaffii GS115
- Mutation(s): Yes
- Deposited: 2015-01-22 Released: 2016-02-03
- Funding Organization(s): National Natural Science Foundation of China, NFSC, National Institutes of Health/National Heart, Lung, and Blood Institute (NIH/NHLBI), CAS/SFEA International Partnership Program for Creative Research Teams, NSF of Fujian Province
Experimental Data Snapshot
- Method: X-RAY DIFFRACTION
- Resolution: 1.50 Å
- R-Value Free: 0.209
- R-Value Work: 0.174
- R-Value Observed: 0.176
Starting Model: experimental
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wwPDB Validation 3D Report Full Report
This is version 1.4 of the entry. See complete history.
Literature
To be published.
Macromolecules
Find similar proteins by:
(by identity cutoff) | 3D Structure
Entity ID: 1 | |||||
|---|---|---|---|---|---|
| Molecule | Chains | Sequence Length | Organism | Details | Image |
| Urokinase-type plasminogen activator | A [auth U] | 246 | Homo sapiens | Mutation(s): 5 Gene Names: PLAU EC: 3.4.21.73 |  |
UniProt & NIH Common Fund Data Resources | |||||
Find proteins for P00749 (Homo sapiens) Explore P00749 Go to UniProtKB: P00749 | |||||
PHAROS: P00749 GTEx: ENSG00000122861 | |||||
Entity Groups | |||||
| Sequence Clusters | 30% Identity50% Identity70% Identity90% Identity95% Identity100% Identity | ||||
| UniProt Group | P00749 | ||||
Sequence AnnotationsExpand | |||||
| |||||
Small Molecules
| Ligands 3 Unique | |||||
|---|---|---|---|---|---|
| ID | Chains | Name / Formula / InChI Key | 2D Diagram | 3D Interactions | |
| PGE Query on PGE | D [auth U], E [auth U] | TRIETHYLENE GLYCOL C6 H14 O4 ZIBGPFATKBEMQZ-UHFFFAOYSA-N |  | ||
| SO4 Query on SO4 | B [auth U], C [auth U] | SULFATE ION O4 S QAOWNCQODCNURD-UHFFFAOYSA-L |  | ||
| GOL Query on GOL | F [auth U], G [auth U] | GLYCEROL C3 H8 O3 PEDCQBHIVMGVHV-UHFFFAOYSA-N |  | ||
Experimental Data & Validation
Experimental Data
- Method: X-RAY DIFFRACTION
- Resolution: 1.50 Å
- R-Value Free: 0.209
- R-Value Work: 0.174
- R-Value Observed: 0.176
- Space Group: H 3
Unit Cell:
| Length ( Å ) | Angle ( ˚ ) |
|---|---|
| a = 121.025 | α = 90 |
| b = 121.025 | β = 90 |
| c = 42.774 | γ = 120 |
| Software Name | Purpose |
|---|---|
| REFMAC | refinement |
| HKL-2000 | data reduction |
| HKL-2000 | data scaling |
| MOLREP | model building |
Entry History & Funding Information
Deposition Data
- Released Date: 2016-02-03 Deposition Author(s): Gong, L., Proulle, V., Hong, Z., Lin, Z., Liu, M., Yuan, C., Lin, L., Furie, B., Flaumenhaft, R., Andreasen, P., Furie, B., Huang, M.
| Funding Organization | Location | Grant Number |
|---|---|---|
| National Natural Science Foundation of China | China | 31161130356 |
| NFSC | China | 31370737 |
| National Institutes of Health/National Heart, Lung, and Blood Institute (NIH/NHLBI) | United States | HL087203 |
| National Institutes of Health/National Heart, Lung, and Blood Institute (NIH/NHLBI) | United States | HL095084 |
| CAS/SFEA International Partnership Program for Creative Research Teams | China | -- |
| NSF of Fujian Province | China | 2012J05071 |
Revision History (Full details and data files)
- Version 1.0: 2016-02-03
Type: Initial release - Version 1.1: 2017-10-18
Changes: Author supporting evidence, Derived calculations - Version 1.2: 2022-03-23
Changes: Author supporting evidence, Database references - Version 1.3: 2023-11-08
Changes: Data collection, Refinement description - Version 1.4: 2024-11-20
Changes: Structure summary
