Download MendeleySubstrate inhibition of protein in tryptophan biosynthesis pathway redirects flux to aromatic catabolism in Acinetobacter baylyi ADP1.
Evans, G.E., Nigon, L.V., Ponniah, K., Burr, N., Anderson, B.F., Norris, G.E., Patrick, W.M.To be published.
4YI7
Anthranilate bound at active site of anthranilate phosphoribosyl transferase from Acinetobacter (AnPRT; TrpD)
- PDB DOI: https://doi.org/10.2210/pdb4YI7/pdb
- Classification: TRANSFERASE
- Organism(s): Acinetobacter baylyi ADP1
- Expression System: Escherichia coli
- Mutation(s): No
- Deposited: 2015-02-28 Released: 2015-09-02
Experimental Data Snapshot
- Method: X-RAY DIFFRACTION
- Resolution: 1.85 Å
- R-Value Free: 0.258
- R-Value Work: 0.223
- R-Value Observed: 0.225
Starting Model: experimental
View more details
wwPDB Validation 3D Report Full Report
This is version 2.0 of the entry. See complete history.
Literature
To be published.
Macromolecules
Find similar proteins by:
(by identity cutoff) | 3D Structure
Entity ID: 1 | |||||
|---|---|---|---|---|---|
| Molecule | Chains | Sequence Length | Organism | Details | Image |
| Anthranilate phosphoribosyltransferase | 365 | Acinetobacter baylyi ADP1 | Mutation(s): 0 Gene Names: trpD, ACIAD2462 EC: 2.4.2.18 |  | |
UniProt | |||||
Find proteins for P00500 (Acinetobacter baylyi (strain ATCC 33305 / BD413 / ADP1)) Explore P00500 Go to UniProtKB: P00500 | |||||
Entity Groups | |||||
| Sequence Clusters | 30% Identity50% Identity70% Identity90% Identity95% Identity100% Identity | ||||
| UniProt Group | P00500 | ||||
Sequence AnnotationsExpand | |||||
| |||||
Small Molecules
| Ligands 1 Unique | |||||
|---|---|---|---|---|---|
| ID | Chains | Name / Formula / InChI Key | 2D Diagram | 3D Interactions | |
| BE2 Query on BE2 | B [auth A] | 2-AMINOBENZOIC ACID C7 H7 N O2 RWZYAGGXGHYGMB-UHFFFAOYSA-N |  | ||
Experimental Data & Validation
Experimental Data
- Method: X-RAY DIFFRACTION
- Resolution: 1.85 Å
- R-Value Free: 0.258
- R-Value Work: 0.223
- R-Value Observed: 0.225
- Space Group: C 2 2 21
Unit Cell:
| Length ( Å ) | Angle ( ˚ ) |
|---|---|
| a = 60.997 | α = 90 |
| b = 70.83 | β = 90 |
| c = 169.156 | γ = 90 |
| Software Name | Purpose |
|---|---|
| XDS | data reduction |
| XDS | data scaling |
| Aimless | data scaling |
| PHASER | phasing |
| PHENIX | refinement |
Entry History
Deposition Data
- Released Date: 2015-09-02 Deposition Author(s): Evans, G.L., Newton, M.S., Norris, G.E., Patrick, W.M.
Revision History (Full details and data files)
- Version 1.0: 2015-09-02
Type: Initial release - Version 1.1: 2015-12-09
Changes: Database references - Version 1.2: 2017-11-22
Changes: Derived calculations, Refinement description - Version 1.3: 2023-09-27
Changes: Data collection, Database references, Refinement description - Version 2.0: 2023-11-15
Changes: Atomic model, Data collection
