Stk10 with Bosutinib
Elkins, J.M., Salah, E., Knapp, S.To be published.
Experimental Data Snapshot
Entity ID: 1 | |||||
---|---|---|---|---|---|
Molecule | Chains | Sequence Length | Organism | Details | Image |
SERINE/THREONINE-PROTEIN KINASE 10 | 295 | Homo sapiens | Mutation(s): 0  EC: 2.7.11.1 | ||
UniProt & NIH Common Fund Data Resources | |||||
Find proteins for O94804 (Homo sapiens) Explore O94804  Go to UniProtKB:  O94804 | |||||
PHAROS:  O94804 GTEx:  ENSG00000072786  | |||||
Entity Groups   | |||||
Sequence Clusters | 30% Identity50% Identity70% Identity90% Identity95% Identity100% Identity | ||||
UniProt Group | O94804 | ||||
Sequence AnnotationsExpand | |||||
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Ligands 3 Unique | |||||
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ID | Chains | Name / Formula / InChI Key | 2D Diagram | 3D Interactions | |
DB8 Query on DB8 | C [auth A], F [auth B] | 4-[(2,4-dichloro-5-methoxyphenyl)amino]-6-methoxy-7-[3-(4-methylpiperazin-1-yl)propoxy]quinoline-3-carbonitrile C26 H29 Cl2 N5 O3 UBPYILGKFZZVDX-UHFFFAOYSA-N | |||
EDO Query on EDO | E [auth A] | 1,2-ETHANEDIOL C2 H6 O2 LYCAIKOWRPUZTN-UHFFFAOYSA-N | |||
CL Query on CL | D [auth A] | CHLORIDE ION Cl VEXZGXHMUGYJMC-UHFFFAOYSA-M |
Length ( Å ) | Angle ( ˚ ) |
---|---|
a = 41.19 | α = 90 |
b = 108.1 | β = 90 |
c = 144.27 | γ = 90 |
Software Name | Purpose |
---|---|
REFMAC | refinement |
MOSFLM | data reduction |
Aimless | data scaling |
PHASER | phasing |