Crystal structure of mouse CARM1 in complex with inhibitor SA0491
Cura, V., Marechal, N., Mailliot, J., Troffer-Charlier, N., Wurtz, J.M., Bonnefond, L., Cavarelli, J.To be published.
Experimental Data Snapshot
Starting Model: experimental
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Entity ID: 1 | |||||
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Molecule | Chains | Sequence Length | Organism | Details | Image |
Histone-arginine methyltransferase CARM1 | 361 | Mus musculus | Mutation(s): 0  Gene Names: Carm1, Prmt4 EC: 2.1.1.319 | ||
UniProt & NIH Common Fund Data Resources | |||||
Find proteins for Q9WVG6 (Mus musculus) Explore Q9WVG6  Go to UniProtKB:  Q9WVG6 | |||||
IMPC:  MGI:1913208 | |||||
Entity Groups   | |||||
Sequence Clusters | 30% Identity50% Identity70% Identity90% Identity95% Identity100% Identity | ||||
UniProt Group | Q9WVG6 | ||||
Sequence AnnotationsExpand | |||||
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Ligands 5 Unique | |||||
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ID | Chains | Name / Formula / InChI Key | 2D Diagram | 3D Interactions | |
6D0 Query on 6D0 | I [auth B], O [auth D] | 5'-{[(3S)-3-amino-3-carboxypropyl](3-bromo-2-oxopropyl)amino}-5'-deoxyadenosine C17 H24 Br N7 O6 DHRFKRQEQCVPMB-UOYPZJKHSA-N | |||
SAO Query on SAO | E [auth A], K [auth C] | 5'-S-[(3S)-3-azaniumyl-3-carboxypropyl]-5'-thioadenosine C14 H21 N6 O5 S ZJUKTBDSGOFHSH-WFMPWKQPSA-O | |||
M2M Query on M2M | N [auth C] | 1-METHOXY-2-(2-METHOXYETHOXY)ETHANE C6 H14 O3 SBZXBUIDTXKZTM-UHFFFAOYSA-N | |||
DXE Query on DXE | M [auth C], Q [auth D] | 1,2-DIMETHOXYETHANE C4 H10 O2 XTHFKEDIFFGKHM-UHFFFAOYSA-N | |||
EDO Query on EDO | F [auth A] G [auth A] H [auth A] J [auth B] L [auth C] | 1,2-ETHANEDIOL C2 H6 O2 LYCAIKOWRPUZTN-UHFFFAOYSA-N |
Length ( Å ) | Angle ( ˚ ) |
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a = 79.123 | α = 90 |
b = 101.043 | β = 90 |
c = 211.349 | γ = 90 |
Software Name | Purpose |
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PHENIX | refinement |
HKL-2000 | data reduction |
SCALEPACK | data scaling |
PHASER | phasing |