Crystal structure of mouse CARM1 in complex with inhibitor SA0592
Cura, V., Marechal, N., Mailliot, J., Troffer-Charlier, N., Wurtz, J.M., Bonnefond, L., Cavarelli, J.To be published.
Experimental Data Snapshot
Starting Model: experimental
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Entity ID: 1 | |||||
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Molecule | Chains | Sequence Length | Organism | Details | Image |
Histone-arginine methyltransferase CARM1 | 361 | Mus musculus | Mutation(s): 0  Gene Names: Carm1, Prmt4 EC: 2.1.1.319 | ||
UniProt & NIH Common Fund Data Resources | |||||
Find proteins for Q9WVG6 (Mus musculus) Explore Q9WVG6  Go to UniProtKB:  Q9WVG6 | |||||
IMPC:  MGI:1913208 | |||||
Entity Groups   | |||||
Sequence Clusters | 30% Identity50% Identity70% Identity90% Identity95% Identity100% Identity | ||||
UniProt Group | Q9WVG6 | ||||
Sequence AnnotationsExpand | |||||
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Ligands 5 Unique | |||||
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ID | Chains | Name / Formula / InChI Key | 2D Diagram | 3D Interactions | |
6CZ Query on 6CZ | O [auth B] | 5'-{[(3S)-3-amino-3-carboxypropyl](3-ethoxy-2,3-dioxopropyl)amino}-5'-deoxyadenosine C19 H27 N7 O8 IYHWPVZKSOPQIK-JHTGIODLSA-N | |||
SAO Query on SAO | K [auth A], S [auth C], U [auth D] | 5'-S-[(3S)-3-azaniumyl-3-carboxypropyl]-5'-thioadenosine C14 H21 N6 O5 S ZJUKTBDSGOFHSH-WFMPWKQPSA-O | |||
M2M Query on M2M | J [auth A] | 1-METHOXY-2-(2-METHOXYETHOXY)ETHANE C6 H14 O3 SBZXBUIDTXKZTM-UHFFFAOYSA-N | |||
PEG Query on PEG | H [auth A], I [auth A], N [auth B] | DI(HYDROXYETHYL)ETHER C4 H10 O3 MTHSVFCYNBDYFN-UHFFFAOYSA-N | |||
EDO Query on EDO | E [auth A] F [auth A] G [auth A] L [auth B] M [auth B] | 1,2-ETHANEDIOL C2 H6 O2 LYCAIKOWRPUZTN-UHFFFAOYSA-N |
Length ( Å ) | Angle ( ˚ ) |
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a = 74.555 | α = 90 |
b = 98.446 | β = 90 |
c = 205.792 | γ = 90 |
Software Name | Purpose |
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PHENIX | refinement |
HKL-2000 | data reduction |
SCALEPACK | data scaling |
PHASER | phasing |