Download MendeleyA structure of the GEF Kalirin DH1 domain in complex with the small GTPase Rac1
Gray, J., Krojer, T., Talon, R., Fairhead, M., Bountra, C., Arrowsmith, C.H., Edwards, A., Brennan, P., von Delft, F.To be published.
5O33
A structure of the GEF Kalirin DH1 domain in complex with the small GTPase Rac1
- PDB DOI: https://doi.org/10.2210/pdb5O33/pdb
- Classification: HYDROLASE
- Organism(s): Homo sapiens, Rattus norvegicus
- Expression System: Escherichia coli
- Mutation(s): No
- Deposited: 2017-05-23 Released: 2017-05-31
Experimental Data Snapshot
- Method: X-RAY DIFFRACTION
- Resolution: 1.64 Å
- R-Value Free: 0.240
- R-Value Work: 0.207
- R-Value Observed: 0.208
Starting Model: experimental
View more details
This is version 1.2 of the entry. See complete history.
Literature
To be published.
Macromolecules
Find similar proteins by:
(by identity cutoff) | 3D Structure
Entity ID: 1 | |||||
|---|---|---|---|---|---|
| Molecule | Chains | Sequence Length | Organism | Details | Image |
| Ras-related C3 botulinum toxin substrate 1 | 177 | Homo sapiens | Mutation(s): 0 Gene Names: RAC1, TC25, MIG5 EC: 3.6.5.2 |  | |
UniProt & NIH Common Fund Data Resources | |||||
Find proteins for P63000 (Homo sapiens) Explore P63000 Go to UniProtKB: P63000 | |||||
PHAROS: P63000 GTEx: ENSG00000136238 | |||||
Entity Groups | |||||
| Sequence Clusters | 30% Identity50% Identity70% Identity90% Identity95% Identity100% Identity | ||||
| UniProt Group | P63000 | ||||
Sequence AnnotationsExpand | |||||
| |||||
Find similar proteins by:
(by identity cutoff) | 3D Structure
Entity ID: 2 | |||||
|---|---|---|---|---|---|
| Molecule | Chains | Sequence Length | Organism | Details | Image |
| Kalirin | 180 | Rattus norvegicus | Mutation(s): 0 Gene Names: Kalrn, Duo, Hapip EC: 2.7.11.1 |  | |
UniProt | |||||
Find proteins for P97924 (Rattus norvegicus) Explore P97924 Go to UniProtKB: P97924 | |||||
Entity Groups | |||||
| Sequence Clusters | 30% Identity50% Identity70% Identity90% Identity95% Identity100% Identity | ||||
| UniProt Group | P97924 | ||||
Sequence AnnotationsExpand | |||||
| |||||
Small Molecules
| Ligands 2 Unique | |||||
|---|---|---|---|---|---|
| ID | Chains | Name / Formula / InChI Key | 2D Diagram | 3D Interactions | |
| GDP Query on GDP | E [auth A] | GUANOSINE-5'-DIPHOSPHATE C10 H15 N5 O11 P2 QGWNDRXFNXRZMB-UUOKFMHZSA-N |  | ||
| EDO Query on EDO | C [auth A] D [auth A] F [auth B] G [auth B] H [auth B] | 1,2-ETHANEDIOL C2 H6 O2 LYCAIKOWRPUZTN-UHFFFAOYSA-N |  | ||
Experimental Data & Validation
Experimental Data
- Method: X-RAY DIFFRACTION
- Resolution: 1.64 Å
- R-Value Free: 0.240
- R-Value Work: 0.207
- R-Value Observed: 0.208
- Space Group: P 65 2 2
Unit Cell:
| Length ( Å ) | Angle ( ˚ ) |
|---|---|
| a = 63.255 | α = 90 |
| b = 63.255 | β = 90 |
| c = 346.704 | γ = 120 |
| Software Name | Purpose |
|---|---|
| PHENIX | refinement |
| xia2 | data reduction |
| xia2 | data scaling |
| PHENIX | phasing |
Entry History
Deposition Data
- Released Date: 2017-05-31 Deposition Author(s): Gray, J., Krojer, T., Talon, R., Fairhead, M., Bountra, C., Arrowsmith, C.H., Edwards, A., Brennan, P., von Delft, F.
Revision History (Full details and data files)
- Version 1.0: 2017-05-31
Type: Initial release - Version 1.1: 2019-10-16
Changes: Data collection - Version 1.2: 2024-01-17
Changes: Data collection, Database references, Refinement description
